Results 21 to 30 of about 9,101,712 (212)

LINE-1 Methylation Status Correlates Significantly to Post-Therapeutic Recurrence in Stage III Colon Cancer Patients Receiving FOLFOX-4 Adjuvant Chemotherapy. [PDF]

PLoS ONE, 2014
Methylation levels of long interspersed nucleotide elements (LINE-1) are representative of genome-wide methylation status and crucial in maintaining genomic stability and expression.
Yun-Ting Lou, Chao-Wen Chen, Yun-Ching Fan, Wei-Chiao Chang, Chien-Yu Lu, I-Chen Wu, Wen-Hung Hsu, Ching-Wen Huang, Jaw-Yuan Wang   +8 more
doaj   +1 more source

Monitoring dynamic cytotoxic chemotherapy response in castration-resistant prostate cancer using plasma cell-free DNA (cfDNA)

BMC Research Notes, 2019
Objective Cell-free DNA (cfDNA) is an attractive cancer biomarker, as it is thought to reflect a component of the underlying genetic makeup of the tumor and is readily accessible in serial fashion.
Katherin Patsch, Naim Matasci, Anjana Soundararajan, Patricia Diaz, David B. Agus, Daniel Ruderman, Mitchell E. Gross   +6 more
doaj   +1 more source

Interspersed repeated elements analysis in Camelus dromedarius CSN1S2 gene.

, 2021
The αs2-casein (CN) is a milk protein fraction encoded by the CSN1S2 gene. Previous studies on dromedary milk proteins mainly focused on the other three fractions (αs1-, β- and k-CN), and, although there is globally growing interested in camel milk,
COSENZA G., PAUCIULLO A., VERSACE C., GALLO D., MOHAMMED A. A. S., GASPA G.   +5 more
core   +1 more source

Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2- b ]carbazole (FICZ), a tryptophan photoproduct [PDF]

Proceedings of the National Academy of Sciences, 2010
Long interspersed nucleotide element-1 (L1) is a retroelement comprising about 17% of the human genome, of which 80–100 copies are competent as mobile elements (retrotransposition: L1-RTP). Although the genetic structures modified during L1-RTP have been clarified, little is known about the cellular signaling cascades involved ...
Noriyuki, Okudaira, Kenta, Iijima, Takayoshi, Koyama, Yuzuru, Minemoto, Shigeyuki, Kano, Akio, Mimori, Yukihito, Ishizaka   +6 more
openaire   +2 more sources

Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs

Mobile DNA, 2011
Long interspersed elements, type 1(LINE-1, L1) are the most abundant and only active autonomous retrotransposons in the human genome. Native L1 elements are inefficiently expressed because of a transcription elongation defect thought to be caused by high
An Wenfeng, Dai Lixin, Niewiadomska Anna, Yetil Alper, O'Donnell Kathryn A, Han Jeffrey S, Boeke Jef D   +6 more
doaj   +1 more source

Soy Isoflavone Supplementation Increases Long Interspersed Nucleotide Element-1 (LINE-1) Methylation in Head and Neck Squamous Cell Carcinoma [PDF]

Nutrition and Cancer, 2019
Soy isoflavones have been suggested as epigenetic modulating agents with effects that could be important in carcinogenesis. Hypomethylation of LINE-1 has been associated with head and neck squamous cell carcinoma (HNSCC) development from oral premalignant lesions and with poor prognosis.
Laura S. Rozek, Shama Virani, Emily L. Bellile, Jeremy M. G. Taylor, Maureen A. Sartor, Katie R. Zarins, A. Virani, C. Cote, Francis P. Worden, Mark E. Prince Mark, Scott A. McLean, Sonya A. Duffy, George H. Yoo, Nabil F. Saba, Dong M. Shin, Omer Kucuk, Gregory T. Wolf   +16 more
openaire   +2 more sources

Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana [PDF]

, 2014
Different combinations of variable number of tandem repeat (VNTR) loci have been proposed for genotyping Mycobacterium tuberculosis complex (MTBC). Existing VNTR schemes show different discriminatory capacity among the six human MTBC lineages.
Michael Selasi Nyaho (542676), Yeboah-Manu, Dorothy, Borrell, Sonia, Adwoa Asante-Poku, Michael Selasi Nyaho, Sebastien Gagneux (149824), Iñaki Comas (57109), Dorothy Yeboah-Manu (120059), Gagneux, Sebastien, Adwoa Asante-Poku (335717), Sebastien Gagneux, Sonia Borrell (149821), Comas, Iñaki, Dorothy Yeboah-Manu, Nyaho, Michael Selasi, Sonia Borrell, Asante-Poku, Adwoa, Iñaki Comas   +17 more
core   +1 more source

MaGIC: a program to generate targeted marker sets for genome-wide association studies

BioTechniques, 2004
High-throughput genotyping technologies such as DNA pooling and DNA microarrays mean that whole-genome screens are now practical for complex disease gene discovery using association studies.
Claire L. Simpson, Valerie K. Hansen, Pak C. Sham, Andrew Collins, John F. Powell, Ammar Al-Chalabi   +5 more
doaj   +1 more source

Retrotransposition of Long Interspersed Nucleotide Element-1 Is Associated with Colitis but Not Tumors in a Murine Colitic Cancer Model

PLOS ONE, 2015
Long interspersed element-1 (L1) is a transposable element that can move within the genome, potentially leading to genome diversity and modified gene function. Although L1 activity in somatic cells is normally suppressed through DNA methylation, some L1s are activated in tumors including colorectal carcinoma. However, how L1-retrotransposition (L1-RTP)
Takeshi Otsubo, Tadashi Okamura, Teruki Hagiwara, Yukihito Ishizaka, Taeko Dohi, Yuki I Kawamura   +5 more
openaire   +4 more sources

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
Joets, Johann, Moore, Jonathan D., Heslop-Harrison, J. (John), King , Graham J., Ryder, C. D., Heslop-Harrison, J. S., Joets, J., Bailey, John P., Moore, J., Ryder, Carol D., Bailey, J. P., Alix, K., Barker, G. C., King, G. J., Barker, Guy C., Alix, Karine   +15 more
core   +1 more source