Results 91 to 100 of about 492,946 (224)

Nano‐Topography Enhanced Topological‐Cell‐Analysis in Radiation‐Therapy

Advanced Healthcare Materials, EarlyView.
Radiotherapy, a treatment that implies exposition of cells to radiation, offers promise to treat cancer. Here, it is hypothesized that the nanoscale details of a scaffold can amplify the response of cells to radiation, measured through topological variables, providing ways to assess the efficacy of Radiotherapy treatment.
Francesca Pagliari, Maria‐Francesca Spadea, Pierre Montay‐Gruel, Anggraeini Puspitasari‐Kokko, Joao Seco, Luca Tirinato, Angelo Accardo, Francesco De Angelis, Francesco Gentile   +8 more
wiley   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Regulation of mammalian cell differentiation by long non‐coding RNAs

, 2012
Wenqian Hu, Juan R. Alvarez‐Dominguez, Harvey F. Lodish   +2 more
openalex   +2 more sources

Transcriptome interrogation of human myometrium identifies differentially expressed sense-antisense pairs of protein-coding and long non-coding RNA genes in spontaneous labor at term [PDF]

, 2013
Roberto Romero, Adi L. Tarca, Piya Chaemsaithong, Jezid Miranda, Tinnakorn Chaiworapongsa, Hui Jia, Sonia S. Hassan, Cynthia A. Kalita, Juan Cai, Lami Yeo, Leonard Lipovich   +10 more
openalex   +1 more source

Self‐Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound

Advanced Healthcare Materials, EarlyView.
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng, Sa Du, Rui Yuan, Yuan Zeng, Xuefen Li, Yu‐Wei Wu, Ke Chen, Lei Tao, Zhihui Tang, Xuliang Deng   +9 more
wiley   +1 more source

Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast Carcinoma

, 2012
Karen M. Chisholm, Yue Wan, Rui Li, Kelli Montgomery, Howard Y. Chang, Robert B. West   +5 more
openalex   +2 more sources

Evolutionary conservation of long non-coding RNAs; sequence, structure, function [PDF]

, 2013
Per Johnsson, Leonard Lipovich, Dan Grandér, Kevin V. Morris   +3 more
openalex   +1 more source

Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa

Advanced Materials, EarlyView.
Base editing using nanoneedles efficiently corrects pathogenic variants in the type VII collagen gene of primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. Nanoneedle editing induces minimal and reversible transcriptional perturbations while restoring the production and secretion of functional type VII collagen.
Salman Ahmad Mustfa, Marija Dimitrievska, Cong Wang, Chenlei Gu, Ningjia Sun, Katarzyna Romańczuk, Pawel Karpinski, Łukasz Łaczmański, John A. McGrath, Joanna Jacków‐Malinowska, Ciro Chiappini   +10 more
wiley   +1 more source

Long non-coding RNA: a new player in cancer [PDF]

, 2013
Hua Zhang, Zhenhua Chen, Xinxin Wang, Zunnan Huang, Zhiwei He, Yujie Chen   +5 more
openalex   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source