Results 91 to 100 of about 739,569 (400)

Genome-wide analysis of long non-coding RNA expression and function in colorectal cancer

Tumor Biology, 2017
Long non-coding RNAs (lncRNAs) are widely transcribed in the genome, but their expression profile and roles in colorectal cancer are not well understood.
Fangyuan Jing, Huicheng Jin, Yingying Mao, Yingjun Li, Ye Ding, Chunhong Fan, Kun Chen   +6 more
doaj   +1 more source

Probing Long Non-coding RNA-Protein Interactions

Frontiers in Molecular Biosciences, 2017
Non-coding RNA sequences outnumber the protein-coding genes in the human genome, however our knowledge of their functions is still limited. RNA-binding proteins follow the transcripts, including non-coding RNAs, throughout their life, regulating not only
Jasmine Barra, Jasmine Barra, Eleonora Leucci   +2 more
doaj   +1 more source

Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing [PDF]

Vertebrate genomes encode thousands of non-coding RNAs including short non-coding RNAs (such as microRNAs) and long non-coding RNAs (lncRNAs). Chicken (Gallus gallus) is an important model organism for developmental biology, and the recently assembled ...
Li, Tingting, Wang, Suya, Wu, Rimao, Zhou, Xueya, Zhu, Dahai, Zhang, Yong   +5 more
core   +1 more source

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers [PDF]

, 2012
Background: Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis.
Beck, Andrew H, Brunner, Alayne L, Chang, Howard Y, Edris, Badreddin, Flynn, Ryan A, Foley, Joseph W, Giacomini, Craig P, Gilks, Thea, Guo, Xiangqian, Li, Rui, Montgomery, Kelli, Pollack, Jonathan R, Sweeney, Robert T, Tibshirani, Robert, van de Rijn, Matt, Varma, Sushama, West, Robert B, Witten, Daniela M, Zhu, Shirley X   +18 more
core   +1 more source

Transcriptional read-through of the long non-coding RNA SVALKA governs plant cold acclimation

Nature Communications, 2018
Most DNA in the genomes of higher organisms does not encode proteins, yet much is transcribed by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The biological significance of most lncRNAs is largely unclear.
Peter Kindgren, Ryan Ard, M. Ivanov, S. Marquardt   +3 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Role of Non-coding RNAs in Viral Myocarditis

Frontiers in Cellular and Infection Microbiology, 2020
Viral myocarditis (VMC) is a disease characterized as myocardial parenchyma or interstitium inflammation caused by virus infection, especially Coxsackievirus B3 (CVB3) infection, which has no accurate non-invasive examination for diagnosis and specific ...
Cong Zhang, Cong Zhang, Cong Zhang, Yan Xiong, Lijin Zeng, Lijin Zeng, Lijin Zeng, Zhihua Peng, Zhihua Peng, Zhihua Peng, Zhihao Liu, Hong Zhan, Zhen Yang, Zhen Yang, Zhen Yang   +14 more
doaj   +1 more source

A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules [PDF]

, 2015
RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Alfredo Ferro, Dario Veneziano, Giovanni Nigita   +2 more
core   +2 more sources

Emerging roles of long non‐coding RNA in cancer

Cancer Science, 2018
Since comprehensive analysis of the mammalian genome revealed that the majority of genomic products are transcribed in long non‐coding RNA (lncRNA), increasing attention has been paid to these transcripts.
Anna Sanchez Calle, Yumi Kawamura, Yusuke Yamamoto, F. Takeshita, T. Ochiya   +4 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source