Results 71 to 80 of about 16,781,272 (315)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Long Non-Coding RNAs in Vascular Inflammation [PDF]

Frontiers in Cardiovascular Medicine, 2018
Less than 2% of the genome encodes for proteins. Accumulating studies have revealed a diverse set of RNAs derived from the non-coding genome. Among them, long non-coding RNAs (lncRNAs) have garnered widespread attention over recent years as emerging regulators of diverse biological processes including in cardiovascular disease (CVD).
Haemmig, Stefan, Simion, Viorel, Feinberg, Mark   +2 more
openaire   +5 more sources

The Arabidopsis Hypoxia Inducible AtR8 Long Non-Coding RNA also Contributes to Plant Defense and Root Elongation Coordinating with WRKY Genes under Low Levels of Salicylic Acid

, 2020
AtR8 lncRNA was previously identified in the flowering plant Arabidopsis thaliana as an abundant Pol III-transcribed long non-coding RNA (lncRNA) of approximately 260 nt.
Yasushi Yukawa, Saraswati Nayar, Shuang Li, Sanjay Kapoor, Juan Wu, HuiYuan Jia   +5 more
core   +1 more source

RNA-Mediated Regulation of Meiosis in Budding Yeast

, 2022
Cells change their physiological state in response to environmental cues. In the absence of nutrients, unicellular fungi such as budding yeast exit mitotic proliferation and enter the meiotic cycle, leading to the production of haploid cells that are ...
Vidya Vardhini Pondugala, Krishnaveni Mishra, Mishra, Krishnaveni, Pondugala, Vidya Vardhini   +3 more
core   +1 more source

The Idiopathic Pulmonary Fibrosis-associated single nucleotide polymorphism rs35705950 is transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1) [PDF]

, 2022
LncRNAs are involved in regulatory processes in the human genome, including gene expression. The rs35705950 SNP, previously associated with IPF, overlaps the recently annotated lncRNA AC061979.1, a 1,712 nucleotide transcript located within the MUC5B ...
Edward C. Schwalbe, Manfred Frick, Schwalbe, Edward C., Schwalbe, Ed, Dean J. Thompson, Ifeanyi Enekwa, Gina Abdelaal, Moschos, Sterghios A., Abdelaal, Gina, Fois, Giorgio, Enekwa, Ifeanyi, Frick, Manfred, Ruxandra Neatu, Peter Braubach, Neatu, Ruxandra, Sterghios A. Moschos, Braubach, Peter, Giorgio Fois, Thompson, Dean J., Stephany Veuger, Veuger, Stephany, Thompson, Dean, Moschos, Sterghios   +22 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Long non coding RNA H19: An emerging therapeutic target in fibrosing diseases

Autoimmunity, 2020
Fibrosis is characterised by excessive deposition of the extracellular matrix (ECM) and develops because of fibroblast differentiation during the process of inflammation. There are few effective treatment options for this diseases due to the aetiology of
Juan Li, Long-Ting Cao, Hong-Hui Liu, Xiao-Dong Yin, Jing Wang   +4 more
doaj   +1 more source

Role of MicroRNAs and Long Non-Coding RNAs in Sarcopenia

Cells, 2022
Sarcopenia is an age-related pathological process characterized by loss of muscle mass and function, which consequently affects the quality of life of the elderly.
Jihui Lee, Hara Kang
doaj   +1 more source

Differential Allelic Expression among Long Non-Coding RNAs

, 2021
Long non-coding RNAs (lncRNA) comprise a diverse group of non-protein-coding RNAs >200 bp in length that are involved in various normal cellular processes and disease states, and can affect coding gene expression through mechanisms in cis or in trans ...
Paul T. Spellman, Michael B. Heskett, Mathew J. Thayer   +2 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source