Results 61 to 70 of about 16,781,272 (315)

The lncRNA PARylator promotes PARP1 activation and resistance to DNA‑damaging therapy in esophageal squamous cell carcinoma

Experimental Hematology & Oncology
Background Outcomes for patients with esophageal squamous cell carcinoma (ESCC) remain poor, partly due to treatment resistance, particularly to DNA-damaging therapies.
Teng Fei Qi, Yadong Liu, Jinkun Yang, Yi Meng Yue, Man Man Han, Hongtao Liu, Jing Li, Min Liu, Yuwei Zhang, Jia Hui Kou, Wen Jin Li, Xiaoying Liu, Ting La, Tao Liu, Song Chen, Xu Dong Zhang, Shundong Cang, Liu Teng, Tianli Fan   +18 more
doaj   +1 more source

Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy

Frontiers in Molecular Neuroscience, 2017
Epilepsy is a common neurologic disorder. The underlying pathological processes include synaptic strength, inflammation, ion channels, and apoptosis. Acting as epigenetic factors, non-coding RNAs (ncRNAs) participate in the regulation of pathophysiologic
Yiye Shao, Yiye Shao, Yinghui Chen, Yinghui Chen   +3 more
doaj   +1 more source

Long Non-Coding RNA Function in CD4+ T Cells:What We Know and What Next? [PDF]

, 2019
The non-coding genome has previously been regarded as "junk" DNA; however, emerging evidence suggests that the non-coding genome accounts for some of the greater biological complexity observed in mammals.
Lagos, Dimitris, Katie A. West, West, Dimitris Lagos, Lagos, West, Katie A   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Novel Cis-Regulatory lncRNA, Kalnc2, Downregulates Kalrn Protein-Coding Transcripts in Mouse Neuronal Cells

, 2023
The KALRN gene encodes several multi-domain protein isoforms that localize to neuronal synapses, conferring the ability to grow and retract dendritic spines and shaping axonal outgrowth, dendrite morphology, and dendritic spine re-modeling.
Divya Chaubey, Muneesh Pal, Beena Pillai, Mohit Tanwar   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Long Non-Coding RNAs Regulating Immunity in Insects

, 2017
Recent advances in modern technology have led to the understanding that not all genetic information is coded into protein and that the genomes of each and every organism including insects produce non-coding RNAs that can control different biological ...
Srividya Subramanian, Valluri Satyavathi, Rupam Ghosh   +2 more
core   +1 more source

Crosstalk between Long Non-Coding RNA and Spliceosomal microRNA as a Novel Biomarker for Cancer

, 2023
Non-coding RNAs (ncRNAs) play diverse roles in regulating cellular processes and have been implicated in pathological conditions, including cancer, where interactions between ncRNAs play a role.
Maram Arafat, Ruth Sperling
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Long non-coding RNAs in the atherosclerotic plaque

Atherosclerosis, 2017
Genetic and environmental factors are important components of the development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as regulators of multiple pathophysiological pathways in the cardiovascular system. Here, we investigated potential associations between lncRNAs and atherosclerosis.Tissue samples from atherosclerotic coronary ...
Arslan, Serdal, Berkan, Ocal, Lalem, Torkia, Ozbilum, Nil, Goksel, Sabahattin, Korkmaz, Ozge, Cetin, Nilgun, Devaux, Yvan   +7 more
openaire   +4 more sources