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Long non-coding RNAs and splicing
Essays in Biochemistry, 2021Abstract In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I summarize differences between the splicing efficiency of protein-coding genes and lncRNAs and discuss why non-coding RNAs are spliced less efficiently.
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Long non-coding RNAs and pyroptosis
Clinica Chimica Acta, 2020Long noncoding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides that have no or only a low coding potential. They are involved in the progression of multiple diseases by the regulation of mechanisms related to epigenetic modifications and transcriptional and posttranscriptional processing.
Dong He +4 more
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Long Non-coding RNAs in Rheumatology
2022The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as non-protein encoding RNA transcripts that exceed 200 nucleotides in length. These transcripts have tissue and cell specific patterns of expression and are implicated in a variety of biological processes ...
Susanne N, Wijesinghe +2 more
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Long non-coding RNAs in metastasis
Cancer and Metastasis Reviews, 2017Long non-coding RNA (lncRNA) genes have recently been discovered as key regulators of developmental, physiological, and pathological processes in humans. Recent studies indicate that lncRNAs regulate every step of gene expression, and their aberrant expression can be found in the majority of cancer types. Particularly, lncRNAs were found to function in
Qihong, Huang +2 more
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Long Non-coding RNAs in Parkinson’s Disease
Neurochemical Research, 2021Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder and is associated with a range of motor and non-motor clinical symptoms. The underlying molecular pathogenesis of PD involves a variety of pathways and mechanisms, including α-synuclein proteostasis, mitochondrial dysfunction, oxidative stress, autophagy and apoptosis ...
Chengqi, Xin, Jing, Liu
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Long non-coding RNAs in retinoblastoma
Pathology - Research and Practice, 2019Retinoblastoma represents 3% of all childhood cancers and is the most common intraocular malignant tumor with a highly aggressive and metastatic phenotype. While recent genetic and epigenetic studies have reported new insights into the mechanism of retinoblastoma development, the involvement of regulatory non-coding RNAs remains unclear.
Ming, Yang, Wenbin, Wei
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2011
Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3, 300 of them exist, but to date only the limited number of functional lncRNAs have been identified and ...
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Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3, 300 of them exist, but to date only the limited number of functional lncRNAs have been identified and ...
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Long non-coding RNA HCP5 in cancer
Clinica Chimica Acta, 2021Cancer remains a major threat to human health worldwide. Long non-coding RNA (lncRNA) comprises a group of single-stranded RNA with lengths longer than 200 bp. LncRNAs are aberrantly expressed and play a variety of roles involving multiple cellular processes in cancer.
Yuanzhang Zou, Binghai Chen
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“Going Long”: Long Non-Coding RNAs as Biomarkers
Circulation Research, 2014Protein-coding sequences constitute 200 nucleotides). Since their discovery in 2001, miRNAs have been studied extensively and fundamental insights have been obtained about their synthesis, their repression of target genes, and their involvement in disease processes. Indeed, miRNA therapeutics are already tested in clinical trials. Article, see p 668
Philipp, Skroblin, Manuel, Mayr
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Long non-coding RNAs in schizophrenia
Clinica Chimica ActaLong noncoding RNAs (lncRNAs) have emerged as critical regulators of the pathogenesis of schizophrenia, a complex neuropsychiatric disorder influenced by genetic and environmental factors. These transcripts modulate gene expression through diverse mechanisms, including chromatin remodeling, transcriptional regulation, and posttranscriptional ...
Seyyed Navid, Mousavinejad +6 more
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