Results 71 to 80 of about 728,039 (351)

Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes

PLoS ONE, 2016
Exosomes are 30-150nM membrane-bound secreted vesicles that are readily isolated from biological fluids such as urine (UEs). Exosomes contain proteins, micro RNA (miRNA), messenger RNA (mRNA), and long non-coding RNA (lncRNA) from their cells of origin ...
Claudia Berrondo, J. Flax, V. Kucherov, Aisha Siebert, T. Osinski, Alex F. Rosenberg, Christopher Fucile, Samuel Richheimer, C. Beckham   +8 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing [PDF]

Vertebrate genomes encode thousands of non-coding RNAs including short non-coding RNAs (such as microRNAs) and long non-coding RNAs (lncRNAs). Chicken (Gallus gallus) is an important model organism for developmental biology, and the recently assembled ...
Li, Tingting, Wang, Suya, Wu, Rimao, Zhou, Xueya, Zhu, Dahai, Zhang, Yong   +5 more
core   +1 more source

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers [PDF]

, 2012
Background: Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis.
Beck, Andrew H, Brunner, Alayne L, Chang, Howard Y, Edris, Badreddin, Flynn, Ryan A, Foley, Joseph W, Giacomini, Craig P, Gilks, Thea, Guo, Xiangqian, Li, Rui, Montgomery, Kelli, Pollack, Jonathan R, Sweeney, Robert T, Tibshirani, Robert, van de Rijn, Matt, Varma, Sushama, West, Robert B, Witten, Daniela M, Zhu, Shirley X   +18 more
core   +1 more source

H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma

Nucleic Acids Research, 2016
Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. In our study, we found that lncRNA CCAT1, whose expression is significantly increased and is correlated with outcomes in Esophageal ...
E. Zhang, Liang Han, D. Yin, Xuezhi He, L. Hong, X. Si, M. Qiu, Tongpeng Xu, W. De, Lin Xu, Y. Shu, Jinfei Chen   +11 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The Role of Non-coding RNAs in Viral Myocarditis

Frontiers in Cellular and Infection Microbiology, 2020
Viral myocarditis (VMC) is a disease characterized as myocardial parenchyma or interstitium inflammation caused by virus infection, especially Coxsackievirus B3 (CVB3) infection, which has no accurate non-invasive examination for diagnosis and specific ...
Cong Zhang, Cong Zhang, Cong Zhang, Yan Xiong, Lijin Zeng, Lijin Zeng, Lijin Zeng, Zhihua Peng, Zhihua Peng, Zhihua Peng, Zhihao Liu, Hong Zhan, Zhen Yang, Zhen Yang, Zhen Yang   +14 more
doaj   +1 more source

From Micro to Long: Non-Coding RNAs in Tamoxifen Resistance of Breast Cancer Cells [PDF]

, 2021
Jéssica Fernanda Barazetti, Tayana Shultz Jucoski, Tamyres Mingorance Carvalho, Rafaela Nasser Veiga, Ana Flávia Kohler, Jumanah Baig, Hend Al Bizri, Daniela Fiori Gradia, Sylvie Mader, Jaqueline Carvalho de Oliveira   +9 more
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Into the Wild: GWAS Exploration of Non-coding RNAs [PDF]

, 2018
Genome-wide association studies (GWAS) have proven a fundamental tool to identify common variants associated to complex traits, thus contributing to unveil the genetic components of human disease.
Giral, Hector, Kratzer, Adelheid, Landmesser, Ulf   +2 more
core   +1 more source