Results 81 to 90 of about 588,548 (249)

Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients

Haematologica, 2017
Long non-coding RNAs are defined as transcripts larger than 200 nucleotides but without protein-coding potential. There is growing evidence of the important role of long non-coding RNAs in cancer initiation, development and progression. In this study, we
Etienne De Clara, Morgane Gourvest, Hanjing Ma, François Vergez, Marie Tosolini, Sébastien Dejean, Cécile Demur, Eric Delabesse, Christian Recher, Christian Touriol, Maria Paola Martelli, Brunangelo Falini, Pierre Brousset, Marina Bousquet   +13 more
doaj   +1 more source

Long non-coding RNA SENCR is a positive regulator of ETV2 [PDF]

, 2017
Department of Biological SciencesAlthough long non-coding RNAs (lncRNAs) have emerged as novel regulator of cell fate and gene expression, the regulation of vascular specific transcription factor by lncRNA in generation of induced endothelial cells ...
Jeong, Yujin
core  

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]

, 2015
Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica, Fatica, Alessandro, Morlando, Mariangela   +2 more
core   +2 more sources

Long non-coding RNAs in ovarian cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2018
Long non-coding RNAs (lncRNAs) refer to functional cellular RNAs molecules longer than 200 nucleotides in length. Unlike microRNAs, which have been widely studied, little is known about the enigmatic role of lncRNAs. However, lncRNAs have motivated extensively attention in the past few years and are emerging as potentially important regulators in ...
Jun Li, Bing Wei, Lei Zhan
openaire   +4 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease [PDF]

, 2014
It has been recognized for decades that proteins, which are encoded by our genome and produced via transcription and translation steps, are building blocks that play vital roles in almost all biological processes.
Kataoka, Masaharu, Wang, Da-Zhi
core   +2 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration

European Journal of Medical Research
Objective Intervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential of cartilage oligomeric matrix protein (COMP) and ADAMTS7 (A disintegrin and metalloproteinases with ...
Jing-Yu Ding, Xu Yan, Ren-Jie Zhang, Hua-Qing Zhang, Liang Kang, Chong-Yu Jia, Rick F. Thorne, Xiao-Ying Liu , Cai-Liang Shen   +8 more
doaj   +1 more source

Long non-coding RNA SOX2OT: Expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis [PDF]

, 2015
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region.
Jazi, M.S., Mowla, S.J., Samaei, N.M., Shahryari, A.   +3 more
core   +1 more source

Long non-coding RNAs in the atherosclerotic plaque

Atherosclerosis, 2017
Genetic and environmental factors are important components of the development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as regulators of multiple pathophysiological pathways in the cardiovascular system. Here, we investigated potential associations between lncRNAs and atherosclerosis.Tissue samples from atherosclerotic coronary ...
Arslan, Serdal, Berkan, Ocal, Lalem, Torkia, Ozbilum, Nil, Goksel, Sabahattin, Korkmaz, Ozge, Cetin, Nilgun, Devaux, Yvan   +7 more
openaire   +6 more sources