Results 1 to 10 of about 37,250 (262)

QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Increased variability of QT interval (QTV) has been linked to arrhythmias in animal experiments and multiple clinical situations. Congenital long QT syndrome (LQTS), a pure repolarization disease, may provide important information on the ...
Srikanth Seethala, Prabhpreet Singh, Vladimir Shusterman, Margareth Ribe, Kristina H. Haugaa, Jan Němec   +5 more
doaj   +2 more sources

Congenital long QT syndrome [PDF]

Orphanet Journal of Rare Diseases, 2008
Congenital long QT syndrome (LQTS) is a hereditary cardiac disease characterized by a prolongation of the QT interval at basal ECG and by a high risk of life-threatening arrhythmias. Disease prevalence is estimated at close to 1 in 2,500 live births. The
Celano Giuseppe, Crotti Lia, Dagradi Federica, Schwartz Peter J   +3 more
doaj   +6 more sources

Current and future precision therapy approaches in the long QT syndrome. [PDF]

Med Genet
Nimani S, Barbieri M, Rieder M, Odening KE.   +3 more
europepmc   +3 more sources

In Vitro Drug Screening Using iPSC-Derived Cardiomyocytes of a Long QT-Syndrome Patient Carrying KCNQ1 & TRPM4 Dual Mutation: An Experimental Personalized Treatment

Cells, 2022
Congenital long QT syndrome is a type of inherited cardiovascular disorder characterized by prolonged QT interval. Patient often suffer from syncopal episodes, electrocardiographic abnormalities and life-threatening arrhythmia.
Feifei Wang, Yafan Han, Wanyue Sang, Lu Wang, Xiaoyan Liang, Liang Wang, Qiang Xing, Yankai Guo, Jianghua Zhang, Ling Zhang, Tuerhong Zukela, Jiasuoer Xiaokereti, Yanmei Lu, Xianhui Zhou, Baopeng Tang, Yaodong Li   +15 more
doaj   +1 more source

Long QT interval in resting electrocardiogram– and what next? Sports cardiologist’s point ofview Part 2. From provocative tests to prevention of cardiac events

Pediatria i Medycyna Rodzinna, 2014
Resting electrocardiogram is a basic diagnostic tool used to identify myocardial diseases caused by a genetic defect of ion channels that results in bioelectric instability of cardiomyocytes and the risk of a complex induction of life-threatening ...
Zbigniew Krenc
doaj   +1 more source

Outcome by Sex in Patients With Long QT Syndrome With an Implantable Cardioverter Defibrillator

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Sex differences in outcome have been reported in patients with congenital long QT syndrome. We aimed to report on the incidence of time‐dependent life‐threatening events in male and female patients with long QT syndrome with an implantable ...
Arwa Younis, Mehmet K. Aktas, Spencer Rosero, Valentina Kutyifa, Bronislava Polonsky, Scott McNitt, Nona Sotoodehnia, Peter Kudenchuk, Thomas D. Rea, Dan E. Arking, Ilan Goldenberg, Wojciech Zareba   +11 more
doaj   +1 more source

Long QT interval in Turner syndrome--a high prevalence of LQTS gene mutations. [PDF]

PLoS ONE, 2013
QT-interval prolongation of unknown aetiology is common in Turner syndrome. This study set out to explore the presence of known long QT mutations in Turner syndrome and to examine the corrected QT-interval (QTc) over time and relate the findings to the ...
Christian Trolle, Kristian H Mortensen, Lisbeth N Pedersen, Agnethe Berglund, Henrik K Jensen, Niels H Andersen, Claus H Gravholt   +6 more
doaj   +1 more source

Reprogramming of a human induced pluripotent stem cell line (ZZUSAHi004-A) from a long QT syndrome patient with a heterozygous AKAP9 (c. 4021C > A) mutant

Stem Cell Research, 2022
Long QT syndrome is one of the most common hereditary arrhythmias in clinic. Mutations in AKAP9 gene can lead to long QT syndrome type 11 (LQT11). In this study, a human induced pluripotent stem cell line ZZUSAHi004-A from a 3-year-old male patient with ...
Tongbin Ding, Wenli Zhu, Xiaowei Li, Liguo Jian   +3 more
doaj   +1 more source

GENETIC ASPECTS OF CONGENITAL LONG QT SYNDROME

Рациональная фармакотерапия в кардиологии, 2015
The main symptoms and clinical types of long QT syndrome are described. Molecular genetic diagnostics and updated approaches to the management of patients with long QT syndrome arepresented.
A. A. Chernova, S. Yu. Nikulina, A. V. Gul'bis   +2 more
doaj   +3 more sources

Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review

The Scientific World Journal, 2012
Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death ...
Eleftherios M. Kallergis, Christos A. Goudis, Emmanuel N. Simantirakis, George E. Kochiadakis, Panos E. Vardas   +4 more
doaj   +1 more source