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Congenital long QT syndrome [PDF]
Orphanet Journal of Rare Diseases, 2008 Congenital long QT syndrome (LQTS) is a hereditary cardiac disease characterized by a prolongation of the QT interval at basal ECG and by a high risk of life-threatening arrhythmias. Disease prevalence is estimated at close to 1 in 2,500 live births. The
Celano Giuseppe +3 more
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Indian Pacing and Electrophysiology Journal, 2002 The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited
G. Michael Vincent
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Case Report: Two cases of recurrent syncope caused by KCNH2 gene mutation in congenital long QT syndrome [PDF]
Frontiers in Cardiovascular MedicineThis study presents two cases of congenital long QT syndrome caused by KCNH2 gene mutations. It highlights the critical role of genetic testing in its diagnosis and underscores the importance of early detection and personalized treatment strategies to ...
Aihua Xing +5 more
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Canadian Medical Association Journal, 2011 In a First Nation community located northeast of Haida Gwaii in British Columbia, a 38-year-old woman required resuscitation from an apparent cardiac arrest that had occurred while she was coaching at a competitive sports event. She had a history of syncope and palpitations.
Heather, Jackson +3 more
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Europace, 2001 The Long QT syndrome (LQTS) is an inherited arrhythmogenic disease occurring in the structurally normal heart that may cause sudden death and that usually manifests in children and teen-agers (1). The prevalence of this disorder is still undefined, however it is estimated to be between 1:10000–1:5000.
Priori, SG, Bloise, R, Crotti, L
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Cells, 2022 Congenital long QT syndrome is a type of inherited cardiovascular disorder characterized by prolonged QT interval. Patient often suffer from syncopal episodes, electrocardiographic abnormalities and life-threatening arrhythmia.
Feifei Wang +15 more
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Hepatology, EarlyView., 2022 Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou +13 more
wiley +1 more source
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
Trends in Cardiovascular Medicine, 1992 The familial long-QT syndrome (LQTS) is an infrequently occurring disorder in which affected family members have QT prolongation on the ECG, often associated with recurrent syncope and fatal ventricular arrhythmias. Autosomal recessive and autosomal dominant modes of inheritance were suggested by the pattern of occurrence of this disorder in the first ...
Arthur J. Moss, Jennifer L. Robinson
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Journal of the American College of Cardiology, 2008 The hereditary long QT syndrome (LQTS) is a genetic channelopathy with variable penetrance that is associated with increased propensity to syncope, polymorphous ventricular tachycardia (torsades de pointes), and sudden arrhythmic death. This inherited cardiac disorder constitutes an important cause of malignant ventricular arrhythmias and sudden ...
Goldenberg, Ilan, Moss, Arthur J.
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