Results 1 to 10 of about 279,908 (354)

QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Increased variability of QT interval (QTV) has been linked to arrhythmias in animal experiments and multiple clinical situations. Congenital long QT syndrome (LQTS), a pure repolarization disease, may provide important information on the ...
Srikanth Seethala, Prabhpreet Singh, Vladimir Shusterman, Margareth Ribe, Kristina H. Haugaa, Jan Němec   +5 more
doaj   +2 more sources

Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review [PDF]

The Scientific World Journal, 2012
Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death ...
Eleftherios M. Kallergis, Christos A. Goudis, Emmanuel N. Simantirakis, George E. Kochiadakis, Panos E. Vardas   +4 more
doaj   +4 more sources

Long QT Syndrome: Genetics and Future Perspective [PDF]

Pediatric Cardiology, 2019
Long QT syndrome (LQTS) is an inherited primary arrhythmia syndrome that may present with malignant arrhythmia and, rarely, risk of sudden death. The clinical symptoms include palpitations, syncope, and anoxic seizures secondary to ventricular arrhythmia,
Eimear Wallace, Linda Howard, Min Liu, Timothy O’Brien, Deirdre Ward, Sanbing Shen, Terence Prendiville   +6 more
openalex   +2 more sources

Congenital Short QT Syndrome [PDF]

Indian Pacing and Electrophysiology Journal, 2004
Long QT intervals in the ECG have long been associated with sudden cardiac death. The congenital long QT syndrome was first described in individuals with structurally normal hearts in 1957.1 Little was known about the significance of a short QT ...
Charles Antzelevitch, Johnson Francis
doaj   +2 more sources

Current and future precision therapy approaches in the long QT syndrome. [PDF]

Med Genet
Nimani S, Barbieri M, Rieder M, Odening KE.   +3 more
europepmc   +2 more sources

Diagnosis, management and therapeutic strategies for congenital long QT syndrome

Heart, 2021
Congenital long QT syndrome (LQTS) is characterised by heart rate corrected QT interval prolongation and life-threatening arrhythmias, leading to syncope and sudden death.
A. Wilde, A. Amin, P. Postema
semanticscholar   +1 more source

Use of Artificial Intelligence and Deep Neural Networks in Evaluation of Patients With Electrocardiographically Concealed Long QT Syndrome From the Surface 12-Lead Electrocardiogram.

JAMA cardiology, 2021
Importance Long QT syndrome (LQTS) is characterized by prolongation of the QT interval and is associated with an increased risk of sudden cardiac death.
J. Bos, Z. Attia, D. Albert, P. Noseworthy, P. Friedman, M. Ackerman   +5 more
semanticscholar   +1 more source

In Vitro Drug Screening Using iPSC-Derived Cardiomyocytes of a Long QT-Syndrome Patient Carrying KCNQ1 & TRPM4 Dual Mutation: An Experimental Personalized Treatment

Cells, 2022
Congenital long QT syndrome is a type of inherited cardiovascular disorder characterized by prolonged QT interval. Patient often suffer from syncopal episodes, electrocardiographic abnormalities and life-threatening arrhythmia.
Feifei Wang, Yafan Han, Wanyue Sang, Lu Wang, Xiaoyan Liang, Liang Wang, Qiang Xing, Yankai Guo, Jianghua Zhang, Ling Zhang, Tuerhong Zukela, Jiasuoer Xiaokereti, Yanmei Lu, Xianhui Zhou, Baopeng Tang, Yaodong Li   +15 more
doaj   +1 more source

Suppression-Replacement KCNQ1 Gene Therapy for Type 1 Long QT Syndrome.

Circulation, 2021
Background: Type 1 long QT syndrome (LQT1) is caused by loss-of-function variants in the KCNQ1-encoded Kv7.1 potassium channel α-subunit which is essential for cardiac repolarization, providing the slow delayed rectifier current (IKs).
BA Steven M. Dotzler, Cs, PhD John Kim, BS William A.C. Gendron, MD Wei Zhou, MD Dan Ye, M. P. J. Martijn Bos, BS David J. Tester, PhD Michael A. Barry, M. P. Michael J. Ackerman, Ph.D Mayo Clinic, Windland   +11 more
semanticscholar   +1 more source

An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia.
A. Adler, V. Novelli, A. Amin, E. Abiusi, M. Care, E. Nannenberg, H. Feilotter, S. Amenta, D. Mazzà, H. Bikker, A. Sturm, John Garcia, M. Ackerman, R. E. Hershberger, M. Perez, W. Zareba, J. Ware, A. Wilde, M. Gollob   +18 more
semanticscholar   +1 more source