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Congenital long QT syndrome [PDF]

Orphanet Journal of Rare Diseases, 2008
Congenital long QT syndrome (LQTS) is a hereditary cardiac disease characterized by a prolongation of the QT interval at basal ECG and by a high risk of life-threatening arrhythmias. Disease prevalence is estimated at close to 1 in 2,500 live births. The
Celano Giuseppe, Crotti Lia, Dagradi Federica, Schwartz Peter J   +3 more
doaj   +11 more sources

Long QT Syndrome [PDF]

Journal of the American College of Cardiology, 2008
The hereditary long QT syndrome (LQTS) is a genetic channelopathy with variable penetrance that is associated with increased propensity to syncope, polymorphous ventricular tachycardia (torsades de pointes), and sudden arrhythmic death. This inherited cardiac disorder constitutes an important cause of malignant ventricular arrhythmias and sudden ...
Arthur J. Moss, Ilan Goldenberg
core   +11 more sources

Long QT Syndrome: [PDF]

Cardiology Clinics, 2000
In conclusion, much has been learned in the past several years regarding the molecular biology of LQTS, and this information has been directly applicable to the clinical care of patients with this syndrome. The knowledge also has been of considerable importance for understanding the molecular basis of arrhythmias in general and is providing insights ...
Michael C. Sanguinetti
openalex   +4 more sources

Update on long QT syndrome [PDF]

Journal of Cardiovascular Electrophysiology, 2019
Long QT syndrome (LQTS) is an inherited disorder characterized by a prolonged QT interval in the 12‐lead electrocardiogram and increased risk of malignant arrhythmias in patients with a structurally normal heart. Since its first description in the 1950s,
Victor Neira, A. Enriquez, C. Simpson, A. Baranchuk   +3 more
semanticscholar   +5 more sources

Low Penetrance in the Long-QT Syndrome [PDF]

Circulation, 1999
BACKGROUND It is still currently held that most patients affected by the long-QT syndrome (LQTS) show QT interval prolongation or clinical symptoms. This is reflected by the assumption in linkage studies of a penetrance of 90%.
Silvia G. Priori, Carlo Napolitano, Peter J. Schwartz   +2 more
openalex   +2 more sources

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Cell, 1995
Mark Curran, Igor Splawski, Katherine W. Timothy, G.Michael Vincen, Eric D. Green, Mark T. Keating   +5 more
openalex   +2 more sources

The Long QT Syndrome

Indian Pacing and Electrophysiology Journal, 2002
The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited
G. Michael Vincent
doaj   +2 more sources

Spectrum of Mutations in Long-QT Syndrome Genes [PDF]

Circulation, 2000
Igor Splawski, Jiaxiang Shen, Katherine W. Timothy, Michael H. Lehmann, Silvia G. Priori, Jennifer L. Robinson, Arthur J. Moss, Peter J. Schwartz, Jeffrey A. Towbin, G. Michael Vincent, Mark T. Keating   +10 more
openalex   +2 more sources

Long QT Syndrome

JACC: Case Reports, 2023
Domenico Corrado, MD, PhD, Domenico Trovato, MD, Alessandro Zorzi, MD, PhD   +2 more
doaj   +2 more sources

A structural basis for drug-induced long QT syndrome [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2000
John S. Mitcheson, Jun Chen, Monica Lin, Chris Culberson, Michael C. Sanguinetti   +4 more
openalex   +2 more sources