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Congenital long QT syndrome [PDF]
Orphanet Journal of Rare Diseases, 2008 Congenital long QT syndrome (LQTS) is a hereditary cardiac disease characterized by a prolongation of the QT interval at basal ECG and by a high risk of life-threatening arrhythmias. Disease prevalence is estimated at close to 1 in 2,500 live births. The
Celano Giuseppe +3 more
doaj +11 more sources
Journal of the American College of Cardiology, 2008 The hereditary long QT syndrome (LQTS) is a genetic channelopathy with variable penetrance that is associated with increased propensity to syncope, polymorphous ventricular tachycardia (torsades de pointes), and sudden arrhythmic death. This inherited cardiac disorder constitutes an important cause of malignant ventricular arrhythmias and sudden ...
Arthur J. Moss, Ilan Goldenberg
core +11 more sources
Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review [PDF]
The Scientific World Journal, 2012 Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death ...
Eleftherios M. Kallergis +4 more
doaj +4 more sources
The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model [PDF]
Chaos Vol 14 pages 172-182 (2004), 2004 In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a description of the long QT 3 syndrome, and is studied in both one dimension, corresponding to a ...
Cherry E. M. +3 more
arxiv +3 more sources
Annals of Noninvasive Electrocardiology, 1998 Major progress has taken place, and at a very rapid pace, in the understanding of the congenital long QT syndrome (LQTS). This has been the direct consequence of the identification of several of the genes responsible for LQTS and of the studies that have followed, at both basic and clinical levels.
Silvia G. Priori, Peter J. Schwartz
openaire +5 more sources
Spectrum of Mutations in Long-QT Syndrome Genes [PDF]
Circulation, 2000 BackgroundLong-QT Syndrome (LQTS) is a cardiovascular disorder characterized by prolongation of the QT interval on ECG and presence of syncope, seizures, and sudden death.
Igor Splawski +10 more
openalex +2 more sources
Pueraria mirifica, an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1‐T587M [PDF]
Journal of Arrhythmia, 2021 After taking an estrogen-containing supplement derived from a tropical plant Pueraria mirifica, a 24-year-old woman presented marked QT prolongation and repetitive torsade de pointes.
Asami Kashiwa +7 more
doaj +2 more sources
Clarithromycin-Induced Long QT Syndrome: A Case Report [PDF]
Case Reports in Medicine, 2012 Long QT syndrome develops for a number of reasons. The number of non-antiarrhythmic drugs reported to induce QT interval prolongation with or without torsade de pointes continues to increase.
Mecnun Cetin +4 more
doaj +3 more sources
Long QT Syndrome and Pregnancy [PDF]
Journal of the American College of Cardiology, 2007 This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years.Only limited data exist regarding the risks associated with pregnancy in women with LQTS.The risk of experiencing an adverse cardiac event, including syncope, aborted cardiac arrest, and sudden death, during and
Seth R +17 more
openaire +5 more sources
Cardiology Clinics, 2000 In conclusion, much has been learned in the past several years regarding the molecular biology of LQTS, and this information has been directly applicable to the clinical care of patients with this syndrome. The knowledge also has been of considerable importance for understanding the molecular basis of arrhythmias in general and is providing insights ...
Michael C. Sanguinetti
openaire +4 more sources