Results 1 to 10 of about 278,546 (322)

Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review [PDF]

The Scientific World Journal, 2012
Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death ...
Eleftherios M. Kallergis, Christos A. Goudis, Emmanuel N. Simantirakis, George E. Kochiadakis, Panos E. Vardas   +4 more
doaj   +4 more sources

Congenital Short QT Syndrome [PDF]

Indian Pacing and Electrophysiology Journal, 2004
Long QT intervals in the ECG have long been associated with sudden cardiac death. The congenital long QT syndrome was first described in individuals with structurally normal hearts in 1957.1 Little was known about the significance of a short QT ...
Charles Antzelevitch, Johnson Francis
doaj   +2 more sources

Diagnosis, management and therapeutic strategies for congenital long QT syndrome

Heart, 2021
Congenital long QT syndrome (LQTS) is characterised by heart rate corrected QT interval prolongation and life-threatening arrhythmias, leading to syncope and sudden death.
A. Wilde, A. Amin, P. Postema
semanticscholar   +1 more source

Use of Artificial Intelligence and Deep Neural Networks in Evaluation of Patients With Electrocardiographically Concealed Long QT Syndrome From the Surface 12-Lead Electrocardiogram.

JAMA cardiology, 2021
Importance Long QT syndrome (LQTS) is characterized by prolongation of the QT interval and is associated with an increased risk of sudden cardiac death.
J. Bos, Z. Attia, D. Albert, P. Noseworthy, P. Friedman, M. Ackerman   +5 more
semanticscholar   +1 more source

In Vitro Drug Screening Using iPSC-Derived Cardiomyocytes of a Long QT-Syndrome Patient Carrying KCNQ1 & TRPM4 Dual Mutation: An Experimental Personalized Treatment

Cells, 2022
Congenital long QT syndrome is a type of inherited cardiovascular disorder characterized by prolonged QT interval. Patient often suffer from syncopal episodes, electrocardiographic abnormalities and life-threatening arrhythmia.
Feifei Wang, Yafan Han, Wanyue Sang, Lu Wang, Xiaoyan Liang, Liang Wang, Qiang Xing, Yankai Guo, Jianghua Zhang, Ling Zhang, Tuerhong Zukela, Jiasuoer Xiaokereti, Yanmei Lu, Xianhui Zhou, Baopeng Tang, Yaodong Li   +15 more
doaj   +1 more source

Suppression-Replacement KCNQ1 Gene Therapy for Type 1 Long QT Syndrome.

Circulation, 2021
Background: Type 1 long QT syndrome (LQT1) is caused by loss-of-function variants in the KCNQ1-encoded Kv7.1 potassium channel α-subunit which is essential for cardiac repolarization, providing the slow delayed rectifier current (IKs).
BA Steven M. Dotzler, Cs, PhD John Kim, BS William A.C. Gendron, MD Wei Zhou, MD Dan Ye, M. P. J. Martijn Bos, BS David J. Tester, PhD Michael A. Barry, M. P. Michael J. Ackerman, Ph.D Mayo Clinic, Windland   +11 more
semanticscholar   +1 more source

An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia.
A. Adler, V. Novelli, A. Amin, E. Abiusi, M. Care, E. Nannenberg, H. Feilotter, S. Amenta, D. Mazzà, H. Bikker, A. Sturm, John Garcia, M. Ackerman, R. E. Hershberger, M. Perez, W. Zareba, J. Ware, A. Wilde, M. Gollob   +18 more
semanticscholar   +1 more source

Drug-induced Fatal Arrhythmias: Acquired long QT and Brugada Syndromes [PDF]

, 2017
Since the early 1990s, the concept of primary “inherited” arrhythmia syndromes or ion channelopathies has evolved rapidly as a result of revolutionary progresses made in molecular genetics.
Ai, Tomohiko, Horie, Minoru, Itoh, Hideki, Turker, Isik   +3 more
core   +1 more source

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable cause of sudden cardiac death in the young.
N. Lahrouchi, R. Tadros, L. Crotti, Y. Mizusawa, P. Postema, L. Beekman, R. Walsh, K. Hasegawa, J. Barc, Mark Ernsting, Kari L. Turkowski, A. Mazzanti, B. Beckmann, K. Shimamoto, Ulla-Britt Diamant, Y. Wijeyeratne, Yu Kucho, T. Robyns, T. Ishikawa, E. Arbelo, Michael Christiansen, A. Winbo, R. Jabbari, S. Lubitz, J. Steinfurt, B. Rudic, B. Loeys, M. Shoemaker, P. Weeke, R. Pfeiffer, B. Davies, A. Andorin, N. Hofman, F. Dagradi, M. Pedrazzini, D. Tester, J. Bos, G. Sarquella-Brugada, Ó. Campuzano, P. Platonov, B. Stallmeyer, S. Zumhagen, E. Nannenberg, J. Veldink, Leonard H van den Berg, A. Al-Chalabi, C. Shaw, P. Shaw, K. Morrison, P. M. Andersen, M. Müller-Nurasyid, D. Cusi, C. Barlassina, P. Galan, M. Lathrop, M. Munter, T. Werge, M. Ribasés, T. Aung, C. Khor, M. Ozaki, P. Lichtner, T. Meitinger, J. P. van Tintelen, Y. Hoedemaekers, I. Denjoy, A. Leenhardt, C. Napolitano, W. Shimizu, J. Schott, J. Gourraud, T. Makiyama, S. Ohno, H. Itoh, A. Krahn, Charles Antzelevitch, D. Roden, J. Saenen, M. Borggrefe, K. Odening, P. Ellinor, J. Tfelt-Hansen, J. Skinner, Maarten P. van den Berg, M. Olesen, J. Brugada, Ramon Brugada, N. Makita, J. Breckpot, M. Yoshinaga, E. Behr, A. Rydberg, T. Aiba, S. Kääb, S. Priori, P. Guicheney, H. Tan, C. Newton‐Cheh, M. Ackerman, P. Schwartz, E. Schulze-Bahr, V. Probst, M. Horie, A. Wilde, M. Tanck, C. Bezzina   +105 more
semanticscholar   +1 more source

Long QT syndrome in a neonate [PDF]

, 2015
Congenital long QT syndrome (cLQTS) is a channelopathy characterized by ventricular repolarization disturbances. The clinical presentation varies from an asymptomatic patient to a patient with recurrent syncopes, seizures, and even sudden death.
Morales Rodríguez, Idelma Berenise, Rodríguez Balderrama, Isaías, Rodríguez Bonito, Rogelio, Rodríguez Martínez, V.   +3 more
core   +1 more source