Results 1 to 10 of about 235,290 (313)

QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Increased variability of QT interval (QTV) has been linked to arrhythmias in animal experiments and multiple clinical situations. Congenital long QT syndrome (LQTS), a pure repolarization disease, may provide important information on the ...
Srikanth Seethala, Prabhpreet Singh, Vladimir Shusterman, Margareth Ribe, Kristina H. Haugaa, Jan Němec   +5 more
doaj   +1 more source

Congenital long QT syndrome in children [PDF]

Medicinski Podmladak, 2016
Long QT syndrome (LQTS) is a cardiac repolarization disorder characterized by prolonged QT interval on the electrocardiogram (ECG) and increased propensity to ventricular tachyarrhythmias and cardiac events.
Cerović Ivana, Košutić Jovan
doaj   +1 more source

Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome.

Circulation: Arrhythmia and Electrophysiology, 2019
BACKGROUND Long QT syndrome is a potentially lethal yet highly treatable cardiac channelopathy. Although β-blocker therapy is standard for most patients, concomitant therapy with sodium channel blockers, like mexiletine, is often utilized for patients ...
J. Bos, L. Crotti, Ram K. Rohatgi, S. Castelletti, F. Dagradi, P. Schwartz, M. Ackerman   +6 more
semanticscholar   +1 more source

Selective acquired long QT syndrome (saLQTS) upon risperidone treatment

BMC Psychiatry, 2012
Background Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel.
Lazarczyk Maciej, Bhuiyan Zahir A, Perrin Nicolas, Giannakopoulos Panteleimon   +3 more
doaj   +1 more source

Acquired Long QT Syndrome and Electrophysiology of Torsade de Pointes

Arrhythmia & Electrophysiology Review, 2019
Congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. Although congenital LQTS remains the domain of cardiologists, cardiac electrophysiologists and specialised centres, the much more frequently acquired LQTS is the
N. El-Sherif, G. Turitto, M. Boutjdir
semanticscholar   +1 more source

Exploring the impact of a KCNH2 missense variant on Long QT syndrome: insights into a novel gender-selective, incomplete penetrance inheritance mode

Frontiers in Genetics
BackgroundLong QT syndrome (LQTS) is an inherited malignant arrhythmia syndrome that poses a risk of sudden death. Variants in the Potassium Voltage-Gated Channel Subfamily H Member 2 (KCNH2) gene are known to cause Long QT syndrome through an autosomal ...
Peng Chen, Peng Chen, Zainul Zampawala, Hong Wang, Luyun Wang   +4 more
doaj   +1 more source

Vomiting, electrolyte disturbance, and medications; the perfect storm for acquired long QT syndrome and cardiac arrest: a case report

Journal of Medical Case Reports, 2022
Background Acquired long QT syndrome is an important and preventable cause of cardiac arrest. Certain medications and electrolyte disturbance are common contributors, and often coexist. In this case, we report five contributors to cardiac arrest.
K. D. Tiver, D. Dharmaprani, J. X. Quah, A. Lahiri, K. E. Waddell-Smith, A. N. Ganesan   +5 more
doaj   +1 more source

Case Report: Expanding the Phenotypic Spectrum of Timothy Syndrome Type 1: A Sporadic Case With a de novo CACNA1C Pathogenic Variant and Segmental Ileal Dilatation

Frontiers in Pediatrics, 2021
Background: Long QT syndactyly syndrome (long QT syndrome type 8), also known as Timothy Syndrome (TS) was first described in 1994 with still <50 case reported in the literature.
Ahmed A. Nugud, Nermeen Mahmoud ELkholy, Awad Alkarim Omar, Abid Qazi, Christos Tzivinikos, Christos Tzivinikos, Nidheesh Chencheri, Sabina Khan, Muhammad Eyad Ba'Ath, Muhammad Eyad Ba'Ath   +9 more
doaj   +1 more source

Determination and Interpretation of the QT Interval: Comprehensive Analysis of a Large Cohort of Long QT Syndrome Patients and Controls

Circulation, 2018
Background: Long QT syndrome (LQTS) is associated with potentially fatal arrhythmias. Treatment is very effective, but its diagnosis may be challenging.
A. Vink, Benjamin Neumann, K. Lieve, Moritz F. Sinner, N. Hofman, Soufiane el Kadi, M. H. Schoenmaker, H. M. Slaghekke, J. D. de Jong, S. Clur, N. Blom, S. Kääb, A. Wilde, P. Postema   +13 more
semanticscholar   +1 more source

Long QT Syndrome in Adults

Journal of the American College of Cardiology, 2007
The aims of this study were: 1) to evaluate risk factors influencing the clinical course of mutation-confirmed adult patients with long QT syndrome (LQTS), 2) to study life-threatening cardiac events as a specific end point in adults, and 3) to examine the protective effect of beta-blocker therapy on cardiac events in adult LQTS patients with known ...
Jeffrey A. Towbin, Jenny B. Hobbs, Andrew J. Sauer, Peter J. Schwartz, Emanuela H. Locati, Arthur J. Moss, Wojciech Zareba, Scott McNitt, Derick R. Peterson, W. Jackson Hall, G. Michael Vincent, Jesaia Benhorin, Elizabeth S. Kaufman, Silvia G. Priori, Carlo Napolitano, Jennifer L. Robinson, Ilan Goldenberg, Li Zhang, Ming Qi, Michael J. Ackerman   +19 more
openaire   +3 more sources