Results 111 to 120 of about 266,382 (322)

Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.

Circulation, 2016
BACKGROUND Risk stratification in patients with type 3 long-QT syndrome (LQT3) by clinical and genetic characteristics and effectiveness of β-blocker therapy has not been studied previously in a large LQT3 population.
A. Wilde, A. Moss, E. Kaufman, W. Shimizu, Derick R. Peterson, J. Benhorin, Coeli M. B. Lopes, J. Towbin, C. Spazzolini, L. Crotti, W. Zareba, I. Goldenberg, Jørgen K. Kanters, Jennifer L. Robinson, M. Qi, N. Hofman, D. Tester, C. Bezzina, M. Alders, T. Aiba, S. Kamakura, Y. Miyamoto, M. Andrews, S. McNitt, B. Polonsky, P. Schwartz, M. Ackerman   +26 more
semanticscholar   +1 more source

Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott, Videha Sharma, Jessica Keen, William Gerard Newman   +3 more
wiley   +1 more source

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141G

Circulation: Cardiovascular Genetics, 2016
Background—Calmodulin (CaM) is encoded by 3 genes, CALM1, CALM2, and CALM3, all of which harbor pathogenic variants linked to long QT syndrome (LQTS) with early and severe expressivity.
N. Boczek, N. Gómez-Hurtado, D. Ye, Melissa L Calvert, D. Tester, D. O. Kryshtal, H. Hwang, Christopher N. Johnson, W. Chazin, Christina G Loporcaro, M. Shah, Andrew L. Papez, Y. Lau, R. Kanter, B. Knollmann, M. Ackerman   +15 more
semanticscholar   +1 more source

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. [PDF]

, 1999
A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral membrane subunit that assembles with HERG, a pore-forming protein, to alter its ...
Antzelevitch, Blumenthal, Busch, Busch, Carmeliet, Carmeliet, Chen, Curran, Daleau, Drici, Duggal, Federico Sesti, Geoffrey W Abbott, Goldstein, Ho, Ho, Howarth, Igor Splawski, Kaczmarek, Katherine W Timothy, Lee, Lees-Miller, Liu, London, Makkar, Marianne E Buck, Mark T Keating, McDonald, Michael H Lehmann, Roden, Roden, Sanguinetti, Sanguinetti, Sanguinetti, Sanguinetti, Scamps, Schulze-Bahr, Sesti, Shibasaki, Smith, Snyders, Spector, Spector, Splawski, Splawski, Steve A.N Goldstein, Tai, Tai, Takumi, Takumi, Trudeau, Tyson, Veldkamp, Vetter, Wang, Wang, Wang, Wang, Wollnik, Yang, Yang, Yang, Yang, Zhou, Zou   +64 more
core   +1 more source

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi, Priya Atodaria, Edmund Appiah‐Kubi, Zainab Shah, Elpidio Marlon Garcia   +4 more
wiley   +1 more source

Long QT syndrome – Bench to bedside

Heart Rhythm O2, 2021
Long QT syndrome (LQTS) is a cardiovascular disorder characterized by an abnormality in cardiac repolarization leading to a prolonged QT interval and T-wave irregularities on the surface electrocardiogram. It is commonly associated with syncope, seizures,
Daniela Ponce-Balbuena, PhD, Isabelle Deschênes, PhD   +1 more
doaj  

Acquired long QT syndrome in chronic kidney disease patients

Renal Failure, 2019
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP ...
Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li   +5 more
semanticscholar   +1 more source

Cardiovascular safety of testosterone therapy—Insights from the TRAVERSE trial and beyond: A position statement of the European Expert Panel for Testosterone Research

Andrology, EarlyView.
Abstract Introduction Testosterone therapy has become a cornerstone treatment for men with hypogonadism, offering significant benefits such as improved sexual function, mood, muscle mass, and bone density. However, concerns about its cardiovascular safety have historically tempered its use.
Michael Zitzmann, Giulia Rastrelli, Robert D Murray, David Edwards, Yacov Reisman, Preethi Mohan Rao, Alexander Sahi, Thomas Hugh Jones, Alberto Ferlin, Eleni Armeni, Emiliano Corpas, Jann‐Frederik Cremers, Janine David, Stefan Arver, Leen Antonio, Giovanni Corona   +15 more
wiley   +1 more source

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

Science Advances, 2017
Long QT syndrome–associated mutations in KCNQ1 most often destabilize the protein, leading to mistrafficking and degradation. Mutations that induce loss of function (LOF) or dysfunction of the human KCNQ1 channel are responsible for susceptibility to a ...
Hui Huang, G. Kuenze, Jarrod A. Smith, K. C. Taylor, A. Duran, Arina Hadziselimovic, J. Meiler, C. Vanoye, A. George, C. Sanders   +9 more
semanticscholar   +1 more source

Evolution in Managing Long QT Syndrome [PDF]

, 2017
n/
Castelletti, Silvia, Dagradi, Federica, Schwartz, Peter J.   +2 more
core   +1 more source