Results 111 to 120 of about 37,848 (274)
Abstract Purpose Extensor mechanism (EM) ruptures after total knee arthroplasty (TKA) are rare but lead to substantial functional impairment and morbidity. Treatment remains challenging due to the diversity of surgical techniques and the limited number of comparative studies.
Bruno Violante +12 more
wiley +1 more source
Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome [PDF]
Kristina H. Haugaa +5 more
openalex +1 more source
Back to Basics: A Curriculum to Address the Pediatric Cardiac Anesthesia Workforce Crisis
ABSTRACT The field of pediatric cardiac anesthesia faces a critical workforce shortage. Survival of children with congenital heart disease (CHD) has improved dramatically, increasing both lifetime procedural demand and case complexity. At the same time, the supply of fellowship‐trained pediatric cardiac anesthesiologists is shrinking due to an aging ...
Lindsey Loveland, Susan C. Nicolson
wiley +1 more source
Phenotype, origin and estimated prevalence of a common long QT syndrome mutation: a clinical, genealogical and molecular genetics study including Swedish R518X/KCNQ1families [PDF]
Annika Winbo +6 more
openalex +1 more source
Grief‐Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model
ABSTRACT Although the death of a loved one is a ubiquitous experience with chest pain a commonly reported symptom, grief‐related chest pain and particularly its physiological mechanisms remain under‐investigated. To address this gap, we adopted Rodger's approach to concept analysis to explore the psychoneuroimmunological mechanisms potentially linking ...
Sophia R. Evstigneev +4 more
wiley +1 more source
ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen +10 more
wiley +1 more source
A Natural History Study of Timothy Syndrome
Background Timothy syndrome (OMIM #601005) is a rare disease caused by variants in the gene CACNA1C. Initially, Timothy syndrome was characterized by a cardiac presentation of long QT syndrome and syndactyly of the fingers and/or toes, all associated ...
Katherine W. Timothy +9 more
doaj +1 more source
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams +7 more
wiley +1 more source
Abstract Milvexian is an oral factor XIa inhibitor in development for prevention of major thromboembolic conditions. This randomized, double‐blind, placebo‐ and positive‐controlled, multiple‐dose, four‐period crossover study assessed the cardic safety of milvexian (including effects on the QT interval of the electrocardiogram), with a supporting in ...
Peter Zannikos +10 more
wiley +1 more source

