Results 61 to 70 of about 7,350,665 (262)
Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach
iNew Medicine, EarlyView.Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT
Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...Shrikant Verma, Sushma Verma, Mohammad Abbas, Tabrez Faruqui, Bashir Ahmad Mir, Farzana Mahdi +5 morewiley +1 more sourceQT Interval Dynamics and Cardiovascular Outcomes: A Cohort Study in an Integrated Health Care Delivery System
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Long QT has been associated with ventricular dysrhythmias, cardiovascular disease (CVD) mortality, and sudden cardiac death. However, no studies to date have investigated the dynamics of within‐person QT change over time in relation to risk of Neha Mantri, Meng Lu, Jonathan G. Zaroff, Neil Risch, Thomas Hoffmann, Akinyemi Oni‐Orisan, Catherine Lee, Eric Jorgenson, Carlos Iribarren +8 moredoaj +1 more sourceCommon Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies [PDF]
, 2009 To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...Rice, K. (Kenneth), Samani, NJ, Jamshidi, Yalda, Chris Wallace (210182), Tobin, M., Carter, Nicholas D., Panos Deloukas, Sanna, Serena, DCCT EDIC Res Grp, Pfeufer, Arne, Snieder, Harold; id_orcid, Fu, J, Patricia B. Munroe (7588601), de Bakker, PIW, Kenneth Rice, Carter, N.D. (Nicholas), Zheng, DL, Wain, LV, Caulfield, M. (Mark), Fu, Jingyuan, Sanna, S, Arking Dan E., Morris Brown, Steve Jeffery, Andrew D. Paterson, Newhouse, Stephen; id_orcid, Deloukas, P, Fu, J. (Jingyuan), John M. Connell (7588580), Nolte, I.M., Sanna, S., Paul I W de Bakker, Dalageorgou, C., Wallace, C. (Chris), Lathrop, Mark, Serena Sanna, null null, Waggott, D. (Daryl), Rice Kenneth, Ilja M. Nolte, John Connell, QTGEN Consortium, Farrall Martin, Brown, M, Morris Brown (238594), Samani, Nilesh J., de Bakke, Paul I. W., Martin Tobin, Gwilliam, R. (Rhian), Gwilliam Rhian, QTSCD Consortium, Nilesh J. Samani (7579793), Farrall, M, Rhian Gwilliam, Jeffery, S., Wallace Chris, Irina Savelieva (262110), Wallace,C., Arne Pfeufer, Newton-Cheh, Christopher, Harold Snieder (103613), Martin Farrall, Gwilliam, Rhian, Arking, D.E., Soranzo, N, Newhouse, SJ, Jamshidi, YM, Snieder Harold, Louise V. Wain (7588511), Spector, Tim D., Zheng, D. (Dongling), Zeggini, E, Waggott, Daryl, Andrew D Paterson, Fu Jingyuan, Snieder, H., Zheng, Dongling, Newton-Cheh Christopher, Arking, D.E. (Dan), Munroe, PB, de Bakker, Paul I. W., Wallace, C, Arking, DE, Zheng, D., Newton-Cheh, C., Nicholas D. Carter (7588595), Jamshidi Yalda, Fu, Jingyuan; id_orcid, Dongling Zheng, Chris Wallace, Eijgelsheim, Mark, Louise V Wain, Lathrop, M, Caulfield, M., Tim D. Spector (7588592), Zeggini, Eleftheria, Irina Savelieva, Serena Sanna (145737), Stephen J. Newhouse (7588577), Ilja M Nolte, Pfeufer, A., Folkert W. Asselbergs, Daryl Waggott, Zeggini Eleftheria, Carter, N.D., Folkert W Asselbergs, Pfeufer Arne, Dan E Arking, Lathrop, M. (Mark), Wallace, Chris, Mark Eijgelsheim (110185), Samani, N.J., Waggott, D, Mark Eijgelsheim, Stephen J Newhouse, Munroe, P. (Patricia), Harold Snieder, ?, ?, Tobin Martin, Patricia B Munroe, Sanna, Serena; id_orcid, Pfeufer, A, Savelieva, I. (Irina), Gwilliam, R, Soranzo, N., Yalda Jamshidi, Paul I.W. de Bakker (7588583), Mark Lathrop, Fu, JY, Connell, J. (John), Martin D. Tobin (7581161), Chrysoula Dalageorgou, Soranzo, N. (Nicole), Arne Pfeufer (76634), Dominiczak, A, Savelieva, Irina, Rice, Kenneth, Jeffery, Steve, Paterson, Andrew D., The DCCT/EDIC Research Group, Waggott, D., Snieder, H, Steve Jeffery (262137), Wellcome Trust Case Control Consor, Eleftheria Zeggini, Jingyuan Fu, Farrall, M., Bakker, P.I.W. (Paul) de, Patricia B. Munroe, Brown, M., Deloukas Panos, Brown Morris, Fu, J., Spector Tim D., Paterson, AD, Eleftheria Zeggini (21702), Nilesh J. Samani, Jeffery, S, DCCT/EDIC Research Group, Nicholas D Carter, Zeggini, E. (Eleftheria), Rice, K., Savelieva Irina, Farrall, Martin, Wain, L.V., Nolte, Ilja M., Tobin, Martin, Samani Nilesh J., Jamshidi, Y, Newhouse, S.J. (Stephen), Andrew D. Paterson (7588598), Nicole Soranzo (12361), Tim D Spector, Wain, Louise V., Savelieva, I., Spector, T.D. (Timothy), Nolte Ilja M., Nolte, I.M. (Ilja), Rice, K, Ilja M. Nolte (7588574), Martin Farrall (62715), Munroe, Patricia B., Zheng Dongling, Gwilliam, R., Nolte, Ilja M.; id_orcid, Eijgelsheim, M., Soranzo, Nicole, Eijgelsheim, M. (Mark), Eijgelsheim Mark, Paterson Andrew D., Carter Nicholas D., Jingyuan Fu (102399), Savelieva, I, Asselbergs, FW, Sanna Serena, Dan E. Arking, Dalageorgou, Chrysoula, Caulfield, Mark, Jeffery, S. (Steve), Anna Dominiczak (262121), Asselbergs, F.W., Deloukas, P., Pfeufer, A. (Arne), Christopher Newton-Cheh, Newhouse, S.J., Wain, L.V. (Louise), Nicole Soranzo, Farrall, M. (Martin), Paul I. W. de Bakker, Asselbergs, Folkert W., Nicholas D. Carter, Dominiczak, A., Chrysoula Dalageorgou (262115), de Bakker, Paul I.W., Wellcome Trust Case Control Consortium, Yalda Jamshidi (262159), Lathrop Mark, Asselbergs, F.W. (Folkert), Newhouse, Stephen J., Brown, Morris, Caulfield, M, Jamshidi, Y., Dalageorgou, C, Snieder, H. (Harold), Louise V. Wain, Wain Louise V., Dalageorgou, C. (Chrysoula), Munroe, P.B., Brown, M.J. (Morris), Samani, N.J. (Nilesh), Zeggini, E., de Bakker, PI, Caulfield Mark, Anna Dominiczak, Eijgelsheim, M, Jamshidi, Y. (Yalda), Deloukas, Panos, Jeffery, Steve Jeffery, Dominiczak Anna, Tobin, M, Rhian Gwilliam (108263), Newton-Cheh, C, Newhouse Stephen J., Spector, T.D., Folkert W. Asselbergs (7588589), Snieder, Harold, Dongling Zheng (262112), Arking, Dan E., Munroe Patricia B., de Bakker, P.I., Demissie, S. (Serkalem), Dan E. Arking (7588586), Mark J. Caulfield (7588472), Tim D. Spector, Mark Lathrop (17971), Christopher Newton-Cheh (79953), Stephen J. Newhouse, Nolte, IM, Paterson, A.D. (Andrew), Zheng, D, Sanna, S. (Serena), Connell, J, Newton-Cheh, C. (Christopher), Connell John, Jeffery Steve, Tobin, M. (Martin), Mark Caulfield, Panos Deloukas (21564), Carter, ND, de Bakker Paul I. W., Asselbergs Folkert W., Dominiczak, A. (Anna), Soranzo Nicole, Paterson, A.D., Dominiczak, Anna, Spector, TD, Nilesh J Samani, Connell, J., Daryl Waggott (135190), Connell, John, Waggott Daryl, Kenneth Rice (211836), Dalageorgou Chrysoula, de Bakker, Paul, Nolte, IM;Wallace, C;Newhouse, SJ;Waggott, D;Fu, J;Soranzo, N;Gwilliam, R;Deloukas, P;Savelieva, I;Zheng, D;Dalageorgou, C;Farrall, M;Samani, NJ;Connell, J;Brown, M;Dominiczak, A;Lathrop, M;Zeggini, E;Wain, LV;Newton-Cheh, C;Eijgelsheim, M;Rice, K;de Bakker, PI;Pfeufer, A;Sanna, S;Arking, DE;Asselbergs, FW;Spector, TD;Carter, ND;Jeffery, S;Tobin, M;Caulfield, M;Snieder, H;Paterson, AD;Munroe, PB;Jamshidi, Y, Rice, Ken +285 morecore +2 more sourcesT-wave alternans in long QT syndrome
Annals of Pediatric Cardiology, 2018 Long QT syndrome (LQTS) is a congenital disorder characterized by prolongation of QT interval in the electrocardiogram (ECG) and a propensity to develop ventricular arrhythmias, which may lead to syncope, cardiac arrest or sudden death. T-wave alternans (Siddharth Narayan Gadagedoaj +1 more sourceUpdate on long QT syndrome [PDF]
Journal of Cardiovascular Electrophysiology, 2019 AbstractLong QT syndrome (LQTS) is an inherited disorder characterized by a prolonged QT interval in the 12‐lead electrocardiogram and increased risk of malignant arrhythmias in patients with a structurally normal heart. Since its first description in the 1950s, advances in molecular genetics have greatly improved our understanding of the cause and ...Víctor Neira, Andrés Enriquez, Chris Simpson, Adrian Baranchuk +3 moreopenaire +3 more sourcesATXN8OS Intermediate Expansion Acts as a Genetic Modifier in Spinocerebellar Ataxia Type 48 (SCA48/STUB1)
Movement Disorders, EarlyView.Abstract Background
Association between monoallelic STUB1 variant and expanded ATXN8OS alleles was recently reported, suggesting a pathogenic interaction that may influence spinocerebellar ataxia type 48 (SCA48) phenotype. Objectives
We investigated the frequency and clinical impact of ATXN8OS in a large cohort of STUB1 carriers compared to individuals Charlotte Mouraux, Jean‐Loup Méreaux, Claire‐Sophie Davoine, Léna Guillot Noel, Emilien Petit, Quentin Thomas, Adem Nasraoui, Anna Heinzmann, Claire Ewenczyk, Alexis Brice, Alexandra Durr, Giulia Coarelli +11 morewiley +1 more sourceDeveloping the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder
Medicinal Research Reviews, EarlyView.ABSTRACT
Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman +15 morewiley +1 more sourceLong QT Syndrome and Pregnancy
Journal of the American College of Cardiology, 2007 This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years.Only limited data exist regarding the risks associated with pregnancy in women with LQTS.The risk of experiencing an adverse cardiac event, including syncope, aborted cardiac arrest, and sudden death, during and Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, Robinson JL, Goldenberg I, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, PRIORI, SILVIA GIULIANA, SCHWARTZ, PETER, Towbin JA, Vincent GM, Zhang L. . +17 moreopenaire +4 more sourcesEmergencies in Amyotrophic Lateral Sclerosis
Muscle &Nerve, EarlyView.ABSTRACT
Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho +9 morewiley +1 more source
