Results 51 to 60 of about 38,746 (286)
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of 5‐HT3 Receptor Antagonists: 2026 Update
Clinical Pharmacology &Therapeutics, EarlyView.5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy‐induced, radiation‐induced, and postoperative nausea and vomiting. Most of the 5‐HT3 receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent Claire Moore, Melissa S. Bourque, Andreas Halman, José A. G. Agúndez, Cynthia A. Prows, Keiko Hikino, Matthias Schwab, Carolyn J. Oxencis, Dharmisha Chauhan, Meta H.M. Diekstra, Susie E. Long, Gillian C. Bell, Andrea Gaedigk, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Rachel Conyers +16 morewiley +1 more sourceCommon Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies [PDF]
, 2009 To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...Rice, K. (Kenneth), Samani, NJ, Jamshidi, Yalda, Chris Wallace (210182), Tobin, M., Carter, Nicholas D., Panos Deloukas, Sanna, Serena, DCCT EDIC Res Grp, Pfeufer, Arne, Snieder, Harold; id_orcid, Fu, J, Patricia B. Munroe (7588601), de Bakker, PIW, Kenneth Rice, Carter, N.D. (Nicholas), Zheng, DL, Wain, LV, Caulfield, M. (Mark), Fu, Jingyuan, Sanna, S, Arking Dan E., Morris Brown, Steve Jeffery, Andrew D. Paterson, Newhouse, Stephen; id_orcid, Deloukas, P, Fu, J. (Jingyuan), John M. Connell (7588580), Nolte, I.M., Sanna, S., Paul I W de Bakker, Dalageorgou, C., Wallace, C. (Chris), Lathrop, Mark, Serena Sanna, null null, Waggott, D. (Daryl), Rice Kenneth, Ilja M. Nolte, John Connell, QTGEN Consortium, Farrall Martin, Brown, M, Morris Brown (238594), Samani, Nilesh J., de Bakke, Paul I. W., Martin Tobin, Gwilliam, R. (Rhian), Gwilliam Rhian, QTSCD Consortium, Nilesh J. Samani (7579793), Farrall, M, Rhian Gwilliam, Jeffery, S., Wallace Chris, Irina Savelieva (262110), Wallace,C., Arne Pfeufer, Newton-Cheh, Christopher, Harold Snieder (103613), Martin Farrall, Gwilliam, Rhian, Arking, D.E., Soranzo, N, Newhouse, SJ, Jamshidi, YM, Snieder Harold, Louise V. Wain (7588511), Spector, Tim D., Zheng, D. (Dongling), Zeggini, E, Waggott, Daryl, Andrew D Paterson, Fu Jingyuan, Snieder, H., Zheng, Dongling, Newton-Cheh Christopher, Arking, D.E. (Dan), Munroe, PB, de Bakker, Paul I. W., Wallace, C, Arking, DE, Zheng, D., Newton-Cheh, C., Nicholas D. Carter (7588595), Jamshidi Yalda, Fu, Jingyuan; id_orcid, Dongling Zheng, Chris Wallace, Eijgelsheim, Mark, Louise V Wain, Lathrop, M, Caulfield, M., Tim D. Spector (7588592), Zeggini, Eleftheria, Irina Savelieva, Serena Sanna (145737), Stephen J. Newhouse (7588577), Ilja M Nolte, Pfeufer, A., Folkert W. Asselbergs, Daryl Waggott, Zeggini Eleftheria, Carter, N.D., Folkert W Asselbergs, Pfeufer Arne, Dan E Arking, Lathrop, M. (Mark), Wallace, Chris, Mark Eijgelsheim (110185), Samani, N.J., Waggott, D, Mark Eijgelsheim, Stephen J Newhouse, Munroe, P. (Patricia), Harold Snieder, ?, ?, Tobin Martin, Patricia B Munroe, Sanna, Serena; id_orcid, Pfeufer, A, Savelieva, I. (Irina), Gwilliam, R, Soranzo, N., Yalda Jamshidi, Paul I.W. de Bakker (7588583), Mark Lathrop, Fu, JY, Connell, J. (John), Martin D. Tobin (7581161), Chrysoula Dalageorgou, Soranzo, N. (Nicole), Arne Pfeufer (76634), Dominiczak, A, Savelieva, Irina, Rice, Kenneth, Jeffery, Steve, Paterson, Andrew D., The DCCT/EDIC Research Group, Waggott, D., Snieder, H, Steve Jeffery (262137), Wellcome Trust Case Control Consor, Eleftheria Zeggini, Jingyuan Fu, Farrall, M., Bakker, P.I.W. (Paul) de, Patricia B. Munroe, Brown, M., Deloukas Panos, Brown Morris, Fu, J., Spector Tim D., Paterson, AD, Eleftheria Zeggini (21702), Nilesh J. Samani, Jeffery, S, DCCT/EDIC Research Group, Nicholas D Carter, Zeggini, E. (Eleftheria), Rice, K., Savelieva Irina, Farrall, Martin, Wain, L.V., Nolte, Ilja M., Tobin, Martin, Samani Nilesh J., Jamshidi, Y, Newhouse, S.J. (Stephen), Andrew D. Paterson (7588598), Nicole Soranzo (12361), Tim D Spector, Wain, Louise V., Savelieva, I., Spector, T.D. (Timothy), Nolte Ilja M., Nolte, I.M. (Ilja), Rice, K, Ilja M. Nolte (7588574), Martin Farrall (62715), Munroe, Patricia B., Zheng Dongling, Gwilliam, R., Nolte, Ilja M.; id_orcid, Eijgelsheim, M., Soranzo, Nicole, Eijgelsheim, M. (Mark), Eijgelsheim Mark, Paterson Andrew D., Carter Nicholas D., Jingyuan Fu (102399), Savelieva, I, Asselbergs, FW, Sanna Serena, Dan E. Arking, Dalageorgou, Chrysoula, Caulfield, Mark, Jeffery, S. (Steve), Anna Dominiczak (262121), Asselbergs, F.W., Deloukas, P., Pfeufer, A. (Arne), Christopher Newton-Cheh, Newhouse, S.J., Wain, L.V. (Louise), Nicole Soranzo, Farrall, M. (Martin), Paul I. W. de Bakker, Asselbergs, Folkert W., Nicholas D. Carter, Dominiczak, A., Chrysoula Dalageorgou (262115), de Bakker, Paul I.W., Wellcome Trust Case Control Consortium, Yalda Jamshidi (262159), Lathrop Mark, Asselbergs, F.W. (Folkert), Newhouse, Stephen J., Brown, Morris, Caulfield, M, Jamshidi, Y., Dalageorgou, C, Snieder, H. (Harold), Louise V. Wain, Wain Louise V., Dalageorgou, C. (Chrysoula), Munroe, P.B., Brown, M.J. (Morris), Samani, N.J. (Nilesh), Zeggini, E., de Bakker, PI, Caulfield Mark, Anna Dominiczak, Eijgelsheim, M, Jamshidi, Y. (Yalda), Deloukas, Panos, Jeffery, Steve Jeffery, Dominiczak Anna, Tobin, M, Rhian Gwilliam (108263), Newton-Cheh, C, Newhouse Stephen J., Spector, T.D., Folkert W. Asselbergs (7588589), Snieder, Harold, Dongling Zheng (262112), Arking, Dan E., Munroe Patricia B., de Bakker, P.I., Demissie, S. (Serkalem), Dan E. Arking (7588586), Mark J. Caulfield (7588472), Tim D. Spector, Mark Lathrop (17971), Christopher Newton-Cheh (79953), Stephen J. Newhouse, Nolte, IM, Paterson, A.D. (Andrew), Zheng, D, Sanna, S. (Serena), Connell, J, Newton-Cheh, C. (Christopher), Connell John, Jeffery Steve, Tobin, M. (Martin), Mark Caulfield, Panos Deloukas (21564), Carter, ND, de Bakker Paul I. W., Asselbergs Folkert W., Dominiczak, A. (Anna), Soranzo Nicole, Paterson, A.D., Dominiczak, Anna, Spector, TD, Nilesh J Samani, Connell, J., Daryl Waggott (135190), Connell, John, Waggott Daryl, Kenneth Rice (211836), Dalageorgou Chrysoula +282 morecore +1 more sourceA phenomap of TTR amyloidosis to aid diagnostic screening
ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.Abstract
Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos +4 morewiley +1 more sourceElectrophysiology of the long qt syndromes [PDF]
Clinical Cardiology, 1990 The long QT syndromes are a collection of disorders, both acquired and congenital, in which episodes of syncope or presyncope occur secondary to a specific ventrticular tachycardia, «torsade de pointes», which arises in the setting of prolongation of ventricular repolarization as manifested by a prolonged QT interval on the surface electrocardiogram ...N J, Linker, D E, Wardopenaire +2 more sourcesCardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency
Epilepsia, EarlyView.Abstract Objective
Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom +9 morewiley +1 more sourceIdiopathic long Q-T syndrome
The Turkish Journal of Pediatrics, 1990
The association of Q-T interval prolongation, syncope and sudden death is known as the long Q-T syndrome. The syndrome may be familial, associated with congenital deafness, or idiopathic.S Ozer, A Celiker, A Oto, S Ozmedoaj Genetics of Long QT Syndrome [PDF]
Methodist DeBakey Cardiovascular Journal, 2014 Long QT syndrome (LQTS) is a potentially life-threatening cardiac arrhythmia characterized by delayed myocardial repolarization that produces QT prolongation and increased risk for torsades des pointes (TdP)-triggered syncope, seizures, and sudden cardiac death (SCD) in an otherwise healthy young individual with a structurally normal heart.David J, Tester, Michael J, Ackermanopenaire +2 more sourcesPrecision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca +3 morewiley +1 more source
