Results 71 to 80 of about 266,382 (322)

Prevalence of Long QT Syndrome in Children with Congenital Sensory-Neural Deafness

Journal of Ardabil University of Medical Sciences, 2021
Background & objectives: Long QT syndrome (LQTS), congenital or acquired disorder, is characterized by a prolonged QT interval associated with syncope attacks and sudden death.
Ahmad Jamei Khosroshahi, Mahmoud Samadi, Shamsi Ghaffari, Akbar Molaei, Fatemeh Chakari   +4 more
doaj  

Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome.

Circulation: Arrhythmia and Electrophysiology, 2019
BACKGROUND Long QT syndrome is a potentially lethal yet highly treatable cardiac channelopathy. Although β-blocker therapy is standard for most patients, concomitant therapy with sodium channel blockers, like mexiletine, is often utilized for patients ...
J. Bos, L. Crotti, Ram K. Rohatgi, S. Castelletti, F. Dagradi, P. Schwartz, M. Ackerman   +6 more
semanticscholar   +1 more source

Risk Factors for Recurrent Syncope and Subsequent Fatal or Near-Fatal Events in Children and Adolescents With Long QT Syndrome [PDF]

, 2011
ObjectivesWe aimed to identify risk factors for recurrent syncope in children and adolescents with congenital long QT syndrome (LQTS).BackgroundData regarding risk assessment in LQTS after the occurrence of the first syncope episode are limited ...
Ackerman, Michael J., Barsheshet, Alon, Benhorin, Jesaia, Goldenberg, Ilan, Jons, Christian, Kaufman, Elizabeth S., Liu, Judy F., Locati, Emanuela H., McNitt, Scott, Moss, Arthur J., Napolitano, Carlo, Peterson, Derick R., Priori, Silvia G., Qi, Ming, Robinson, Jennifer L., Schwartz, Peter J., Towbin, Jeffrey, Vincent, Michael, Zareba, Wojciech, Zhang, Li   +19 more
core   +1 more source

Acquired Long QT Syndrome and Electrophysiology of Torsade de Pointes

Arrhythmia & Electrophysiology Review, 2019
Congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. Although congenital LQTS remains the domain of cardiologists, cardiac electrophysiologists and specialised centres, the much more frequently acquired LQTS is the
N. El-Sherif, G. Turitto, M. Boutjdir
semanticscholar   +1 more source

Fluoxetine Treatment in Epilepsy of Infancy with Migrating Focal Seizures Due to KCNT1 Variants: An Open Label Study

Annals of Neurology, EarlyView.
Objective Gain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy.
Marina Trivisano, Ilaria Mosca, Licia Salimbene, Angela De Dominicis, Paolo Ambrosino, Deborah Puzo, Ilenio Servettini, Cinzia Correale, Chiara Falamesca, Cristina Filosomi, Bianca Goffredo, Maria Virginia Soldovieri, Maurizio Taglialatela, Nicola Specchio   +13 more
wiley   +1 more source

QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Increased variability of QT interval (QTV) has been linked to arrhythmias in animal experiments and multiple clinical situations. Congenital long QT syndrome (LQTS), a pure repolarization disease, may provide important information on the ...
Srikanth Seethala, Prabhpreet Singh, Vladimir Shusterman, Margareth Ribe, Kristina H. Haugaa, Jan Němec   +5 more
doaj   +1 more source

Selective acquired long QT syndrome (saLQTS) upon risperidone treatment

BMC Psychiatry, 2012
Background Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel.
Lazarczyk Maciej, Bhuiyan Zahir A, Perrin Nicolas, Giannakopoulos Panteleimon   +3 more
doaj   +1 more source

Determination and Interpretation of the QT Interval: Comprehensive Analysis of a Large Cohort of Long QT Syndrome Patients and Controls

Circulation, 2018
Background: Long QT syndrome (LQTS) is associated with potentially fatal arrhythmias. Treatment is very effective, but its diagnosis may be challenging.
A. Vink, Benjamin Neumann, K. Lieve, Moritz F. Sinner, N. Hofman, Soufiane el Kadi, M. H. Schoenmaker, H. M. Slaghekke, J. D. de Jong, S. Clur, N. Blom, S. Kääb, A. Wilde, P. Postema   +13 more
semanticscholar   +1 more source

The tacrolimus concentration‐to‐dose ratio is associated with kidney function in heart transplant recipients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen, Teun B. Petersen, Boris C. A. Seijkens, Jasper J. Brugts, Kadir Caliskan, Alina A. Constantinescu, Brenda C. M. de Winter, Isabella Kardys, Dennis A. Hesselink, Olivier Manintveld   +9 more
wiley   +1 more source

Vomiting, electrolyte disturbance, and medications; the perfect storm for acquired long QT syndrome and cardiac arrest: a case report

Journal of Medical Case Reports, 2022
Background Acquired long QT syndrome is an important and preventable cause of cardiac arrest. Certain medications and electrolyte disturbance are common contributors, and often coexist. In this case, we report five contributors to cardiac arrest.
K. D. Tiver, D. Dharmaprani, J. X. Quah, A. Lahiri, K. E. Waddell-Smith, A. N. Ganesan   +5 more
doaj   +1 more source