Results 81 to 90 of about 266,382 (322)

Case Report: Expanding the Phenotypic Spectrum of Timothy Syndrome Type 1: A Sporadic Case With a de novo CACNA1C Pathogenic Variant and Segmental Ileal Dilatation

Frontiers in Pediatrics, 2021
Background: Long QT syndactyly syndrome (long QT syndrome type 8), also known as Timothy Syndrome (TS) was first described in 1994 with still <50 case reported in the literature.
Ahmed A. Nugud, Nermeen Mahmoud ELkholy, Awad Alkarim Omar, Abid Qazi, Christos Tzivinikos, Christos Tzivinikos, Nidheesh Chencheri, Sabina Khan, Muhammad Eyad Ba'Ath, Muhammad Eyad Ba'Ath   +9 more
doaj   +1 more source

Treatement methodes for Long QT syndrome

Journal of Education, Health and Sport, 2018
Long QT syndrome (LQTS) is a potentially fatal cardiac disorder caused by channelopathies. Such arrhythmia is often life threatening and might cause sudden cardiac death. There are many reasons of LQTS especially: specific medications and/or electrolytes
Erwin Ciechański, Magda Ciechańska, Krystian Ciechański, Jarosław Szponar   +3 more
doaj   +3 more sources

Implementing physician‐led medication reviews for patients with diabetes and severe mental disorder: A randomized controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Patients with severe mental disorder and diabetes may be exposed to inappropriate polypharmacy increasing the risk of side effects and drug interactions. Although medication reviews may facilitate short‐term deprescribing, they are not known to affect clinical outcomes.
Johan Frederik Mebus Meyer Christensen, Signe Wegmann Düring, Gesche Jürgens   +2 more
wiley   +1 more source

Exploring the impact of a KCNH2 missense variant on Long QT syndrome: insights into a novel gender-selective, incomplete penetrance inheritance mode

Frontiers in Genetics
BackgroundLong QT syndrome (LQTS) is an inherited malignant arrhythmia syndrome that poses a risk of sudden death. Variants in the Potassium Voltage-Gated Channel Subfamily H Member 2 (KCNH2) gene are known to cause Long QT syndrome through an autosomal ...
Peng Chen, Peng Chen, Zainul Zampawala, Hong Wang, Luyun Wang   +4 more
doaj   +1 more source

A Randomized Thorough QT Trial Using Concentration‐QT Analysis to Evaluate the Effects of Centanafadine on Cardiac Repolarization

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Centanafadine is a norepinephrine/dopamine/serotonin reuptake inhibitor in development for treatment of attention‐deficit/hyperactivity disorder. This double‐blind, placebo‐ and moxifloxacin‐controlled, 3‐period crossover trial evaluated the effects of centanafadine (EB‐1020) and its metabolite (EB‐10601) on cardiac repolarization in 30 ...
Osman S. Turkoglu, Xiaofeng Wang, Jennifer Repella‐Gordon, Susan E. Shoaf   +3 more
wiley   +1 more source

Extremely dangerous hypopituitarism related long QT syndrome and transient ST-segment elevation: A case report

SAGE Open Medical Case Reports, 2023
Acquired long QT syndrome caused by hypopituitarism and transient ST-segment elevation has not been reported in cardiac arrest patients. We report a case of extremely dangerous acquired long QT syndrome and transient ST-segment elevation.
Jia Zhang, Yingying Zou, Xiaoshu Chen, Jingye Pan, Haizhu Yu, Yi Wang, Yanran Wu, He Zou   +7 more
doaj   +1 more source

Molecular Pathophysiology of Congenital Long QT Syndrome.

Physiological Reviews, 2017
Ion channels represent the molecular entities that give rise to the cardiac action potential, the fundamental cellular electrical event in the heart. The concerted function of these channels leads to normal cyclical excitation and resultant contraction ...
Michael S Bohnen, Gary Peng, Seth H. Robey, C. Terrenoire, V. Iyer, K. Sampson, R. Kass   +6 more
semanticscholar   +1 more source

A phenomap of TTR amyloidosis to aid diagnostic screening

ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos   +4 more
wiley   +1 more source

Cardiac structural and molecular alterations in rodent models of temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Cardiac structural and molecular changes are prevalent in people with chronic epilepsy, possibly contributing to an increased risk of premature mortality. However, understanding of the underlying pathophysiological mechanisms is limited.
Zining Liu, Shobi Sivathamboo, Peravina Thergarajan, Flavia M. Gomes, Idrish Ali, Kim L. Powell, Piero Perucca, Nigel C. Jones, Terence J. O'Brien, Pablo Casillas‐Espinosa   +9 more
wiley   +1 more source

Idiopathic long Q-T syndrome

The Turkish Journal of Pediatrics, 1990
The association of Q-T interval prolongation, syncope and sudden death is known as the long Q-T syndrome. The syndrome may be familial, associated with congenital deafness, or idiopathic.
S Ozer, A Celiker, A Oto, S Ozme
doaj