Results 181 to 190 of about 767,416 (302)

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

The interplay of ageing and rheumatic diseases

The Lancet. Healthy Longevity
The Lancet Healthy Longevity
doaj   +1 more source

Integrating exercise into daily life: the potential of "exercise snacks" for healthy longevity. [PDF]

J Nutr Health Aging
Cadore EL, Pietta-Dias C.
europepmc   +1 more source

Beyond Transconductance: Cell‐Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte‐Gated Polymer Transistors

Advanced Science, EarlyView.
High electrical performance alone does not guarantee efficient bioelectronic signal transduction. Despite excellent mixed ionic‐electronic conduction, recordings from cardiomyocytes reveal that p(g2T‐TT)‐based OECTs predominantly transduce field potential FP‐like signals due to weak cell‐polymer coupling.
Giulia Zoe Zemignani, Elena Mancinelli, Gabriele Tullii, Aleksandr Khudiakov, Cristiano Bortolotti, Shubham Tanwar, Peter J. Schwartz, Luca Sala, Maria Rosa Antognazza, Mario Caironi, Adrica Kyndiah   +10 more
wiley   +1 more source

Defining obesity to improve ageing

The Lancet. Healthy Longevity
The Lancet Healthy Longevity
doaj   +1 more source

Upskilling in Healthy Longevity Medicine and Its Association With Physicians' Implementation Intent and Self-Reported Clinical Confidence: Cross-Sectional Observational Study. [PDF]

JMIR Med Educ
Bischof E, Wilczok D, Kirkland JL, Wilaksono B, Huang CY, Suwannaphong S, Sanphasitvong W, Čamdžić D, Hernandez C, Madea Y, Yamada H, Fernandes MA, Gaminha Pacheco R, Serfaty FM, Calvo-Fortes F, Goldman A, Maier AB, Moskalev A, Scheibye-Knudsen M, Zhavoronkov A.   +19 more
europepmc   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Leadership – can you be too old?

The Lancet. Healthy Longevity
The Lancet Healthy Longevity
doaj   +1 more source

Pleiotropic SNPs and genes linked to enhanced seed longevity and vigor for climate resilient pearl millet production. [PDF]

Front Plant Sci
Kannababu N, Nanjundappa S, Malipatil R, Chunduri B, Srikanth A, Venkateswarlu R, Jacob J, Malathi VM, Satyavathi TC, Thirunavukkarasu N.   +9 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source