Results 201 to 210 of about 241,449 (302)

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

RETRACTION: lncRNA OTUD6B-AS1 Exacerbates As₂O₃-Induced Oxidative Damage in Bladder Cancer via miR-6734-5p-Mediated Functional Inhibition of IDH2. [PDF]

Oxid Med Cell Longev
Cellular Longevity OMA.
europepmc   +1 more source

RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans

, 2016
Mihwa Seo, Sang‐Soon Park, Hong Gil Nam, Seung‐Jae Lee   +3 more
openalex   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Contrasting pathways to tree longevity in gymnosperms and angiosperms. [PDF]

Nat Commun
Brienen RJW, Locosselli GM, Krottenthaler S, Gloor E, Wrigley R, Voelker SL, Altman J, Altmanova N, Anderegg LDL, Baliva M, Barua D, Bazant V, Black B, M Brown P, Ceccantini G, DeRose RJ, Villanueva Diaz J, Di Filippo A, Dolezal J, Duchesne L, Earle C, Fibich P, Griesbauer H, Helama S, Klesse S, Korznikov K, Lindenmayer D, Liu S, Lopez L, Mencuccini M, Nagel TA, Pavlin J, Pederson N, Piovesan G, Restaino C, Reich PB, Sauchyn D, Schöngart J, Shaw JD, Smith D, Sunny R, Svoboda M, Villalba R, Wood LJ, Zhang C.   +44 more
europepmc   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

From sick care to healthspan: educating the longevity physician for health maintenance and health promotion. [PDF]

Biogerontology
Thor D, Barzilai D, Lyu YX, Spiru L.
europepmc   +1 more source

Borophene: Crucial Challenges and the Way Forward

Advanced Science, EarlyView.
This review explores the challenges and progress in borophene research, focusing on synthesis strategies, structural properties, and potential applications. It highlights key experimental breakthroughs, discusses theoretical insights into borophene's unique features, and addresses pathways for overcoming stability and scalability issues.
Zhixuan Li, Jeyaraman Sankar, Prashant Kumar, Ajayan Vinu   +3 more
wiley   +1 more source

Thank you to The Lancet Healthy Longevity’s statistical and peer reviewers in 2024

The Lancet. Healthy Longevity
The Lancet Healthy Longevity Editors
doaj   +1 more source

Correction to "DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-κB Signaling". [PDF]

Oxid Med Cell Longev
europepmc   +1 more source