Results 81 to 90 of about 25,301,115 (309)
, 2011 Cognitive impairment is an important topic for longitudinal studies of aging, and one that directly affects ability to participate. We study bias in measured cognition due to non-response in the Health and Retirement Study (HRS) and the English ...
Langa, Kenneth M +2 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
臺灣教育社會學研究, 2006 過去眾多的實證研究結果顯示：社會網絡對心理幸福有很重要的正面影響。由於過去這方面的國內研究較少使用長期追蹤調查資料，以及做適當的統計分析，因此大部分的研究無法釐清這兩個變項因果關聯之方向性。本研究目的在於探討「以上兩個變項之因果方向性到底為何」，這當可為教育社會學開拓一個新的研究議題。本研究使用了1,047位國立臺東師院學生的追蹤調查資料納入統計分析，並對相關干擾變項的影響做進一步控制。貫時性因果分析顯示：心理幸福對社會網絡有正面影響，社會網絡則對心理幸福沒有影響，即得到「心理幸福為因，社會網絡為果 ...
林俊瑩 Chunn-Ying Lin +1 more
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Design effects in the analysis of longitudinal survey data
, 2005 The design effect measures the inflation of the sampling variance of an estimator as a result of the use of a complex sampling scheme. It is usually measured relative to the variance of the estimator under simple random sampling.
Skinner, Chris, Vieira, Marcel de Toledo
core +1 more source