Results 51 to 60 of about 33,267,872 (251)

Delayed heart rate recovery after exercise predicts development of metabolic syndrome: A retrospective cohort study

Journal of Diabetes Investigation, 2022
Aims/Introduction Several cross‐sectional studies have shown that delayed heart rate recovery (HRR) after exercise is associated with the development of metabolic syndrome (MetS).
Tae Yang Yu, Won‐Jung Hong, Sang‐Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Ji Cheol Bae, Jae Hyeon Kim, Moon‐Kyu Lee   +7 more
doaj   +1 more source

Characterizing longitudinal patterns of physical activity in mid-adulthood using latent class analysis: results from a prospective cohort study. [PDF]

, 2011
The authors aimed to describe how longitudinal patterns of physical activity during mid-adulthood (ages 31-53 years) can be characterized using latent class analysis in a population-based birth cohort study, the Medical Research Council's 1946 National ...
G. D. Mishra, D. Nitsch, Nitsch, Dorothea, Silverwood, Richard J., D. Kuh, R. J. Silverwood, M. Pierce, Mishra, Gita D, Silverwood, Richard J, Kuh, Diana, Pierce, Mary, Mishra, Gita D.   +11 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Environments For Healthy Living (EFHL) Griffith birth cohort study: characteristics of sample and profile of antenatal exposures

BMC Public Health, 2012
Background The Environments for Healthy Living (EFHL) study is a repeated sample, longitudinal birth cohort in South East Queensland, Australia. We describe the sample characteristics and profile of maternal, household, and antenatal exposures. Variation
Cameron Cate M, Scuffham Paul A, Shibl Rania, Ng ShuKay, Scott Rani, Spinks Anneliese, Mihala Gabor, Wilson Andrew, Kendall Elizabeth, Sipe Neil, McClure Roderick J   +10 more
doaj   +1 more source

Mortality differences between migrants and Italians residing in Rome before, during, and in the aftermath of the great recession. A longitudinal cohort study from 2001 to 2015

BMC Public Health, 2021
Background In Europe, one of the most consistent findings is that of migrant mortality advantage in high-income countries. Furthermore, the literature shows that economic shocks, which bring worse health outcomes, can severely affect the most ...
Eleonora Trappolini, Claudia Marino, Nera Agabiti, Cristina Giudici, Marina Davoli, Laura Cacciani   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Combined effect of adiposity and elevated inflammation on incident type 2 diabetes: a prospective cohort study

Cardiovascular Diabetology, 2023
Background Adiposity and elevated inflammation are two hallmarks of hyperglycemia. However, it is unknown whether clustering of elevated inflammation and adiposity interact act on diabetogenesis and lead to a greater risk for incident type 2 diabetes ...
Dan Wu, Yulong Lan, Shuohua Chen, Xiong Ding, Guanzhi Chen, Chutao Wu, Lois Balmer, Wencan Xu, Shouling Wu, Wei Wang   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Estudio longitudinal de la representación social del teatro en una cohorte de 25 dramaturgos argentinos de entre 35 y 45 años

Moderna Språk, 2019
With the aim of contributing to the understanding of the recent trends and transformations of the Argentinean independent theater system, this work deepens its analysis by means of a longitudinal panel design on a cohort formed by 25 writers/directors ...
Lucas Rimoldi
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source