Results 61 to 70 of about 33,267,872 (251)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Children’s Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population

Respiratory Research, 2019
Background Single birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and population.
James E. Gern, Daniel J. Jackson, Robert F. Lemanske, Christine M. Seroogy, Umberto Tachinardi, Mark Craven, Stephen Y. Hwang, Carol M. Hamilton, Wayne Huggins, George T. O’Connor, Diane R. Gold, Rachel Miller, Meyer Kattan, Christine C. Johnson, Dennis Ownby, Edward M. Zoratti, Robert A. Wood, Cynthia M. Visness, Fernando Martinez, Anne Wright, Susan Lynch, Carole Ober, Gurjit K. Khurana Hershey, Patrick Ryan, Tina Hartert, Leonard B. Bacharier   +25 more
doaj   +1 more source

Profile and preliminary results of Iranian sub cohort chronic obstructive pulmonary disease (COPD) in Shahrekord PERSIAN cohort in southwest Iran

BMC Pulmonary Medicine, 2021
Background Chronic obstructive pulmonary disease (COPD) is a chronic and complex respiratory disorder associated with airflow limitation and increased inflammatory response of the lungs to harmful particles.
Fatemeh Zeynab Kiani, Ali Ahmadi, Akbar Soleymani Babadi, Hamid Rouhi   +3 more
doaj   +1 more source

An integrated and collaborative approach to developing and scripting questionnaires for longitudinal cohort studies and surveys: experience in Life Study [PDF]

, 2017
Efficient development of questionnaires for longitudinal surveys and cohort studies as computer-assisted survey instruments usually entails close collaboration between scientific and fieldwork teams. We describe a system based on the use of a Structured
Elias, P, Dezateux, Carol, Gilby, Nicholas, Walton, Suzanne, Peskett, Duncan, Nicholas Gilby, Alexandrakis, Stelios, Peter Elias, Carol Dezateux, Firman, N, Duncan Peskett, Dezateux, C, Gilby, N, Elias, Peter, Stelios Alexandrakis, Nicola Firman, Gareth Williams, Alexandrakis, S, Williams, Gareth, Walton, S, Suzanne Walton, Williams, G, Peskett, D, Firman, Nicola   +23 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Survey response over 15 years of follow-up in the Millennium Cohort Study

BMC Medical Research Methodology, 2023
Background Patterns of survey response and the characteristics associated with response over time in longitudinal studies are important to discern for the development of tailored retention efforts aimed at minimizing response bias.
Claire A. Kolaja, Jennifer N. Belding, Satbir K. Boparai, Sheila F. Castañeda, Toni Rose Geronimo-Hara, Teresa M. Powell, Xin M. Tu, Jennifer L. Walstrom, Beverly D. Sheppard, Rudolph P. Rull, for the Millennium Cohort Study Team   +10 more
doaj   +1 more source

High prevalence of physical inactivity among patients from the Swiss HIV cohort study

, 2017
Physical activity (PA) can improve cardiorespiratory status, strength, body composition and quality of life for patients infected with HIV. Evidence from HIV-uninfected populations also shows that PA is associated with a lower risk of mortality ...
Swiss HIV Cohort Study, Calmy, A., Schmidt-Trucksäss, A., Nicca, Dunja, Brun Del Re, C., Hasse, Barbara, Young, Jim, Schäfer, J., Young, J., Brun Del Re, Claudia, Cavassini, M., Schmidt-Trucksäss, Arno, Swiss HIV Cohort Study,, Schäfer, Juliane, Hasse, B., Bucher, Heiner C., Bucher, H.C., Calmy, Alexandra, Bucher, Heiner C, Cavassini, Matthias, Bernasconi, Enos, Nicca, D., Bernasconi, E.   +22 more
core   +1 more source

Predicting smoking cessation and its relapse in HIV-infected patients: the Swiss HIV Cohort Study [PDF]

, 2014
OBJECTIVES: The aim of the study was to assess whether prospective follow-up data within the Swiss HIV Cohort Study can be used to predict patients who stop smoking; or among smokers who stop, those who start smoking again.
H Furrer, Calmy, A., Bucher, H C, The Swiss HIV Cohort Study,, Furrer, H, M Cavassini, Young, J., Cavassini, M., B Ledergerber, Schäfer, J, E Bernasconi, Bucher, H. C., Schäfer, Juliane, Bernasconi, E, Nicca, D, Cavassini, M, Battegay, M., D Nicca, A Calmy, Bucher, H., Ledergerber, B., Ledergerber, B, Calmy, A, Young, J, M Battegay, Swiss HIV Cohort Study, J Young, Nicca, Dunja, Schäfer, J., Furrer, H., J Schäfer, Battegay, M, Nicca, D., HC Bucher, Bernasconi, E.   +34 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Maternal, obstetric and gynecological factors associated with preterm birth in Rwanda: findings from a national longitudinal study

BMC Pregnancy and Childbirth, 2023
Background Preterm birth is one of the key causes of morbidity and mortality among neonates in low-income countries. In Rwanda, at least 35,000 babies are born prematurely each year, and 2600 children under the age of five die due to direct complications
Erigene Rutayisire, Monica Mochama, Corneille Killy Ntihabose, Jean Nepo Utumatwishima, Michael Habtu   +4 more
doaj   +1 more source