Results 71 to 80 of about 33,267,872 (251)

Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study [PDF]

, 2017
We analyzed changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during tenofovir-containing antiretroviral therapy among patients with a replicating HDV infection in the Swiss HIV Cohort Study.
Battegay, Manuel, Sahli, Roland, Wandeler, Gilles, Atkinson, Andrew, Béguelin, Charles, Lüthi, Alexander, Wandeler, G., Battegay, M., Calmy, Alexandra, Swiss HIV Cohort Study, Alexander Lüthi, Schmid, Patrick, Andri Rauch, Schmid, P., Alexandra Calmy, Nicole Friolet, null null, Charles Béguelin, Suter-Riniker, F., Suter-Riniker, Franziska, Franziska Suter-Riniker, Friolet, N., Bernasconi, E., Andrew Atkinson, Patrick Schmid, Calmy, A., Günthard, Huldrych F, Enos Bernasconi, Cavassini, M., Moradpour, Darius, Béguelin, Charles Antoine, Rauch, A., Roland Sahli, Bernasconi, Enos, Gilles Wandeler, Huldrych F. Günthard, Moradpour, D., Lüthi, A., Rauch, Andri, Atkinson, A., Béguelin, C., Günthard, H.F., Manuel Battegay, Friolet, Nicole, Suter, Franziska Marta, Sahli, R., Darius Moradpour, Cavassini, Matthias, Matthias Cavassini   +48 more
core   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Long-Term Trends of the Association Between Falls Among the Elderly in Taiwan and their Utilization of Medical Facilities

International Journal of Gerontology, 2017
Background: Every year many adults aged 65 and over, suffer falls. This study used longitudinal data to investigate the long-term trend of falls among the elderly in Taiwan, and the association between falls and the utilization of medical facilities ...
Kai-Huang Chen, Hui-Min Hsieh, Chun-Min Chen, Herng-Chia Chiu, I-Chen Lee   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The Occurrence and Longitudinal Changes of Cognitive Impairment After Acute Ischemic Stroke

Neuropsychiatric Disease and Treatment, 2020
Xiao-ling Liao,1 Li-jun Zuo,1 Ning Zhang,2 Yang Yang,2 Yue-song Pan,3 Xiang-long Xiang,3 Ling-yun Chen,4 Xia Meng,3 Hao Li,3 Xing-quan Zhao,1 Yi-long Wang,1 Chun-xue Wang,2 Jiong Shi,3 Yong-jun Wang1 On behalf of the Impairment of CognitiON and Sleep ...
Liao X, Zuo L, Zhang N, Yang Y, Pan Y, Xiang X, Chen L, Meng X, Li H, Zhao X, Wang Y, Wang C, Shi J, Wang Y   +13 more
doaj  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Life satisfaction in Norwegian medical doctors: a 15-year longitudinal study of work-related predictors

BMC Health Services Research, 2019
Background Despite many recent studies on burn-out and dissatisfaction among American medical doctors, less is known about doctors in the Scandinavian public health service. The aims of this study were to analyse long-term work-related predictors of life
Javed Iqbal Mahmood, Kjersti Støen Grotmol, Martin Tesli, Torbjørn Moum, Ole Andreassen, Reidar Tyssen   +5 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source