Results 61 to 70 of about 3,187,887 (293)

Integrated noninvasive diagnostics for prediction of survival in immunotherapy

Immuno-Oncology and Technology
Background: Integrating complementary diagnostic data sources promises enhanced robustness in the predictive performance of artificial intelligence (AI) models, a crucial requirement for future clinical validation/implementation.
M. Yeghaian, Z. Bodalal, T.M. Tareco Bucho, I. Kurilova, C.U. Blank, E.F. Smit, M.S. van der Heijden, T.D.L. Nguyen-Kim, D. van den Broek, R.G.H. Beets-Tan, S. Trebeschi   +10 more
doaj   +1 more source

Signal Detection and Monitoring Based on Longitudinal Healthcare Data

Pharmaceutics, 2012
Post-marketing detection and surveillance of potential safety hazards are crucial tasks in pharmacovigilance. To uncover such safety risks, a wide set of techniques has been developed for spontaneous reporting data and, more recently, for longitudinal ...
Iris Pigeot, Marc Suling
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Influence of User Preferences on the Revealed Utility Factor of Plug-In Hybrid Electric Vehicles

World Electric Vehicle Journal, 2019
Plug-in hybrid electric vehicles (PHEVs) are an effective intermediate vehicle technology option in the long-term transition pathway towards light-duty vehicle electrification.
Seshadri Srinivasa Raghavan, Gil Tal
doaj   +1 more source

A bi-dimensional finite mixture model for longitudinal data subject to dropout

, 2017
In longitudinal studies, subjects may be lost to follow-up, or miss some of the planned visits, leading to incomplete response sequences. When the probability of non-response, conditional on the available covariates and the observed responses, still ...
Alfò, Alfò, Alfò, Bartolucci, Beunckens, Creemers, Dempster, Folstein, Gao, Gao, Hauser, Jansen, Little, Ma, Molenberghs, Neuhaus, Oakes, Rakhmawati, Rakhmawati, Rizopoulos, Royall, Rubin, Scharfstein, Schwarz, Troxel, Tsonaka, Verzilli, Viviani, White, White, Wu, Wu, Xie, Xie, Xie   +34 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Model-Free Feature Screening Based on Data Aggregation for Ultra-High-Dimensional Longitudinal Data

Stats
Ultra-high dimensional longitudinal data feature screening procedures are widely studied, but most require model assumptions. The screening performance of these methods may not be excellent if we specify an incorrect model.
Junfeng Chen, Xiaoguang Yang, Jing Dai, Yunming Li   +3 more
doaj   +1 more source

Crossing MGLS with the Middle Grades Research Agenda: A Guide for Researchers [PDF]

, 2018
For the past several years, leaders in middle grades education research have strengthened their call for more methodologically robust quantitative research to address important questions in the field.
Bishop, Penny A, Olofson, Mark W.
core   +2 more sources

Detecting subgroups in social participation among individuals living with spinal cord injury: a longitudinal analysis of community survey data [PDF]

, 2021
Mirja Gross-Hemmi, Christine Fekete, Marcel W. M. Post, Anke Scheel‐Sailer, Urban Schwegler, Martin W. G. Brinkhof   +5 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source