Results 101 to 110 of about 3,681 (209)

Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder [PDF]

, 2016
Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are autoimmune demyelinating diseases distinguished clinically by selective involvement in NMOSD of optic nerves and spinal cord. Early clinical manifestations are
Evans, David R. S., Hakobyan, Svetlana, Harding, Katharine, Loveless, Samantha, Luppe, Sebastian, Morgan, Bryan Paul, Robertson, Neil P.   +6 more
core   +1 more source

Clinical characteristics of autoimmune glial fibrillary acidic protein astrocytopathy in adults: a retrospective analysis of 9 cases

Internal Medicine Journal, Volume 56, Issue 4, Page 589-597, April 2026.
Abstract Background To identify early diagnostic clues, we analysed cerebrospinal fluid and serum biomarkers in patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) and compared biomarker trends with those in patients with viral meningoencephalitis, tuberculous meningoencephalitis, and anti‐N‐methyl‐D‐aspartate receptor ...
Siruo Guo, Jinyu Huang, Tingting Liu, Wu Yang   +3 more
wiley   +1 more source

The role of anti-aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica [PDF]

, 2016
Background: Acute brainstem syndrome (ABS) may herald multiple sclerosis (MS), neuromyelitis optica (NMO), or occur as an isolated syndrome. The aquaporin 4 (AQP4)-specific serum autoantibody, NMO-IgG, is a biomarker for NMO.
A Saiz, AK Probstel, BF Popescu, BG Weinshenker, C Trebst, CH Polman, Chen Cheng, DA McFarling, DK Sato, DM Wingerchuk, DM Wingerchuk, DM Wingerchuk, F Paul, Fu Gu, HJ Kim, I Ayzenberg, I Kleiter, J Kitley, JA Cabrera-Gómez, JF Kurtzke, JH Min, KC Wang, KH Chan, KH Chang, L Chalumeau-Lemoine, L Kremer, M Matiello, M Niino, MP Alvarenga, N Asgari, R Marignier, RC Dale, S Jarius, S Jarius, S Jarius, SH Kim, SJ Pittock, SM Kim, T Matsuoka, T Misu, T Misu, T Takahashi, TF Scott, VA Lennon, Xiaodong Lu, Xueqiang Hu, Y Wang, Ying Jiang, Yongqiang Dai, Z Lu, Zhengqi Lu, Zhuang Kang   +51 more
core   +1 more source

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 581-592, March 2026.
ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih, Sara Samadzadeh, Charlotte Bereuter, Seyedamirhosein Motamedi, Claudia Chien, Pablo Villoslada, Hadas Stiebel‐Kalish, Nasrin Asgari, Yang Mao‐Draayer, Marius Ringelstein, Joachim Havla, Marco Aurélio Lana Peixoto, Ho Jin Kim, Jacqueline Palace, Maria Isabel Leite, Srilakshmi M. Sharma, Fereshteh Ashtari, Rahele Kafieh, Lekha Pandit, Orhan Aktas, Philipp Albrecht, Letizia Leocani, Itay Lotan, Sasitorn Siritho, Jérôme de Seze, Romain Marignier, Caroline Froment Tilikete, Denis Bernardi Bichuetti, Ivan Maynart Tavares, Ayse Altintas, Anu Jacob, Saif Huda, Ibis Soto de Castillo, Lawrence J. Cook, Michael R. Yeaman, Axel Petzold, Alexander U. Brandt, Friedemann Paul, Frederike C. Oertel, Hanna G. Zimmermann, with the Guthy Jackson Charitable Foundation—International Clinical Consortium and CROCTINO Collaborators   +40 more
wiley   +1 more source

A case of tubercular meningoencephalitis with transverse myelitis

Radiology Case Reports
Central nervous system tuberculosis accounts for approximately 1% of all tuberculosis cases. Transverse myelitis is an extremely rare manifestation of central nervous system tuberculosis, involving 1 or more vertebral segments of the spinal cord. However,
Abhikanta Khatiwada, MD, Sharada K C, MD, Anamika Jha, MD, Sashi Sekhar Singh, MD   +3 more
doaj   +1 more source

Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis

Arquivos de Neuro-Psiquiatria, 2014
Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD.
Douglas Kazutoshi Sato, Dagoberto Callegaro, Marco Aurélio Lana-Peixoto, Ichiro Nakashima, Kazuo Fujihara   +4 more
doaj   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 547-561, March 2026.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Influenza Virus Vaccine Efficacy Based On Conserved Sequence Alignment

, 2012
The rapid outbreak of bird flu challenges the outcome of effective vaccine for the upcoming years. The recent research established different norms to eliminate flu pandemics.
Jerald, Baby, Nair, T. R. Gopalakrishnan
core   +1 more source

Hypersensitivity Responses in the Central Nervous System [PDF]

, 2015
Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes include ...
Carsten Tue Berg, Marlene Thorsen Mørch, Nasrin eAsgari, Nasrin eAsgari, Reza eKhorooshi, Trevor eOwens   +5 more
core   +4 more sources

Optical coherence tomography and subclinical optical neuritis in longitudinally extensive transverse myelitis

Annals of Indian Academy of Neurology, 2017
Objective: The aim is to compare the retinal nerve fiber layer (RNFL) thickness of longitudinally extensive transverse myelitis (LETM) eyes without previous optic neuritis with that of healthy control subjects.
Prakash Kumar Sinha, Deepika Joshi, Virendra Pratap Singh, Sujit Deshmukh, Usha Singh, Abhishek Pathak, Vijay Nath Mishra, Rameshwar Nath Chaurasia, Vivek Sharda, Garima Gupta   +9 more
doaj   +1 more source