Results 61 to 70 of about 899,007 (265)

Loop Diuretics

Kidney and Blood Pressure Research, 1987
Loop diuretics such as furosemide, piretanide, and bumetanide bind reversibly to the Na⁺2Cl^-K+ carrier. This transporter is responsible for the uptake of Cl^- into the thick ascending limb segment.
R, Greger, P, Wangemann
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Effects of macrophages in OSCC progression

Frontiers in Immunology
Macrophages are crucial immune cells within the tumor microenvironment (TME), involved in regulating tumor proliferation, invasion, metastasis, ECM remodeling, angiogenesis, and immunosuppression. Although more and more experimental evidence and clinical
Xiaodan Dong, Xiaodan Dong, Chunling Dong, Bo Li   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Em direção ao ruído: loop de desaparecimentos ao rés do corpo

Palíndromo
Este artigo se dedica a uma análise do disco Isto (2019), obra de Cildo Meireles realizada com a voz da locutora Íris Lettieri. Assim como em Isto o artista recorreu ao loop para reunir, sonoramente e sutilmente, ambos os lados do disco, a escrita deste
Caroline Alciones de Oliveira Leite
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Medical Diagnosis Based on Multi-threshold Fuzzy Petri Net with Loop

Journal of Harbin University of Science and Technology
To settle the loop judgement issue of the medical diagnosis process, a multi-threshold fuzzy Petri net with loop (MTFPNL) is proposed to simulate the evidence-based medical diagnosis process of“ initial diagnosis-confirmation”.
ZHANG Xuanyu, ZHOU Kaiqing, XIANG Yinhong, KANG Diwen   +3 more
doaj   +1 more source

A Quantitative Analysis of Sectoral Interrelationship in the Framework of the Structural Path Analysis [PDF]

فصلنامه پژوهش‌های اقتصادی ایران, 2004
In this paper we analyze quantitatively the interrelationship between three major sectors of  the Iranian economy, viz. agriculture, industry and services.
Ali Asghar Banouei, Mohammad Jelowdari Mamaghani, Yaghoob Andayesh, Hassan Alizadeh Asl, Mina Mahmoodi   +4 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source