Results 61 to 70 of about 883,617 (266)

Loop Diuretics

Kidney and Blood Pressure Research, 1987
Loop diuretics such as furosemide, piretanide, and bumetanide bind reversibly to the Na⁺2Cl^-K+ carrier. This transporter is responsible for the uptake of Cl^- into the thick ascending limb segment.
R, Greger, P, Wangemann
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Effects of macrophages in OSCC progression

Frontiers in Immunology
Macrophages are crucial immune cells within the tumor microenvironment (TME), involved in regulating tumor proliferation, invasion, metastasis, ECM remodeling, angiogenesis, and immunosuppression. Although more and more experimental evidence and clinical
Xiaodan Dong, Xiaodan Dong, Chunling Dong, Bo Li   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Em direção ao ruído: loop de desaparecimentos ao rés do corpo

Palíndromo
Este artigo se dedica a uma análise do disco Isto (2019), obra de Cildo Meireles realizada com a voz da locutora Íris Lettieri. Assim como em Isto o artista recorreu ao loop para reunir, sonoramente e sutilmente, ambos os lados do disco, a escrita deste
Caroline Alciones de Oliveira Leite
doaj   +1 more source

A Quantitative Analysis of Sectoral Interrelationship in the Framework of the Structural Path Analysis [PDF]

فصلنامه پژوهش‌های اقتصادی ایران, 2004
In this paper we analyze quantitatively the interrelationship between three major sectors of  the Iranian economy, viz. agriculture, industry and services.
Ali Asghar Banouei, Mohammad Jelowdari Mamaghani, Yaghoob Andayesh, Hassan Alizadeh Asl, Mina Mahmoodi   +4 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Medical Diagnosis Based on Multi-threshold Fuzzy Petri Net with Loop

Journal of Harbin University of Science and Technology
To settle the loop judgement issue of the medical diagnosis process, a multi-threshold fuzzy Petri net with loop (MTFPNL) is proposed to simulate the evidence-based medical diagnosis process of“ initial diagnosis-confirmation”.
ZHANG Xuanyu, ZHOU Kaiqing, XIANG Yinhong, KANG Diwen   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source