TRANSFORM-HF Trial: Choice of loop diuretic in acute heart failure does not matter!
The major clinical manifestations of heart failure (HF) are due to fluid retention and congestion, and thus, therapy targeting congestion plays a central role in HF management. Furosemide is by far the most commonly prescribed loop diuretic.
Akshyaya Pradhan +2 more
doaj +1 more source
KEY POINTS AND PRACTICAL RECOMMENDATIONS: • Although chlorthalidone and hydrochlorothiazide are structurally similar, they are very different pharmacokinetically, with chlorthalidone having both an extremely long half-life (approximately 40 to 60 hours) and a large volume of distribution, with gradual elimination from the plasma compartment by tubular
Domenic A, Sica +3 more
openaire +2 more sources
Renal function, electrolytes, and congestion monitoring in heart failure. [PDF]
Congestion, renal function, and electrolyte imbalance (particularly potassium) are common problems in the management of the complex multi-morbid patient with heart failure (HF).
Chioncel, O +4 more
core +3 more sources
This study employs an AI‐driven multidisciplinary approach to increase our understanding of the toxicological effects of sublethal concentrations of carlina oxide on Prostephanus truncatus. Sublethal exposure to the carlina oxide induced changes in motor patterns and thigmotaxis, highlighting its potential role in integrated pest management strategies.
Anita Casadei +9 more
wiley +1 more source
Guideline-Directed Medical Therapy in the Management of Cardiovascular Disease: A Cross-sectional Questionnaire-based Study amongst Indian Healthcare Professionals [PDF]
Introduction: Guideline-Directed Medical Therapies (GDMT) are evidence-based treatments recommended by clinical practice guidelines for the management of Cardiovascular Diseases (CVDs).
Prafulla Kerkar +9 more
doaj +1 more source
Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. [PDF]
Background Our objective was to determine patterns of antihypertensive agent use by stage of chronic kidney disease (CKD) and to evaluate the association between different classes of antihypertensive agents with nonrenal outcomes, especially in advanced ...
Johansen, Kirsten L +4 more
core
Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study [PDF]
Aims: Episodes of acute heart failure (AHF) unfavourably affect multiple organs, which may have an adverse impact on the outcomes. We investigated the prevalence and clinical consequences of abnormal liver function tests (LFTs) in AHF patients ...
Akhter +20 more
core +1 more source
Long‐term remission in gout: Challenges and future opportunities
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley +1 more source
Diuretics in modern nephrology
The paper considers the problem of using loop diuretics in patients with chronic kidney disease associated with cardiovascular risk, such as heart failure, hypertension, edema syndrome, including those against diabetes mellitus. Three therapeutic margins
D.D. Ivanov
doaj +1 more source
Management of hyperkalemia in the acutely ill patient. [PDF]
PURPOSE:To review the mechanisms of action, expected efficacy and side effects of strategies to control hyperkalemia in acutely ill patients. METHODS:We searched MEDLINE and EMBASE for relevant papers published in English between Jan 1, 1938, and July 1,
Dépret, François +5 more
core +3 more sources

