Results 91 to 100 of about 23,403 (218)

Combination of thiazide and loop diuretics for the treatment of acute heart failure

Cardiologia Hungarica
Acute heart failure (AHF) is a serious condition with a high mortality rate. It is considered as the most common cause of unplanned hospitalizations in the elderly population. In 90% of all cases AHF presents with congestive symptoms, thus mostly treated
Krisztina Fekete, Róbert Halmosi, Tamás Habon   +2 more
doaj   +1 more source

Real‐world risk factors and clinical implications of early estimated glomerular filtration rate decline after sodium‐glucose cotransporter‐2 inhibitor therapy

Journal of Diabetes Investigation, EarlyView.
Older age, atrial fibrillation, loop diuretic use, and higher eGFR variability predicted early eGFR dip. Continued SGLT2 inhibitor therapy preserved long‐term kidney function, although closer monitoring is warranted in patients receiving loop diuretics. ABSTRACT Aim To assess the prevalence, risk factors, estimated glomerular filtration rate trajectory,
Jangwook Lee, Dayoung Kang, Kyoung‐Ah Kim, Han Seok Choi, Soomin Jo, Joeun Kim, Jae Yoon Park, Seung Eun Lee   +7 more
wiley   +1 more source

Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes

Journal of Periodontal Research, EarlyView.
Key Findings Drug‐target Mendelian randomization showed little evidence that genetically proxied on‐target pharmacological actions of most antihypertensive drug classes were associated with chronic periodontitis or dental caries. The diazoxide–periodontitis association requires cautious interpretation, given possible residual pleiotropy at KCNJ11 and ...
Aiswarya Puzhakkara Chennas, Ignacio Leiva‐Escobar, Stefan Lars Reckelkamm, Birte Holtfreter, Thomas Kocher, Sebastian‐Edgar Baumeister, Michael Nolde, Zoheir Alayash   +7 more
wiley   +1 more source

Time series forecasting of weight for diuretic dose adjustment using bidirectional long short-term memory

Scientific Reports
Loop diuretics are prevailing drugs to manage fluid overload in heart failure. However, adjusting to loop diuretic doses is strenuous due to the lack of a diuretic guideline.
Heejung Choi, Yunha Kim, Heejun Kang, Hyeram Seo, Minkyoung Kim, JiYe Han, Gaeun Kee, Seohyun Park, Soyoung Ko, HyoJe Jung, Byeolhee Kim, Jae-Hyung Roh, Tae Joon Jun, Young-Hak Kim   +13 more
doaj   +1 more source

Does Hypoxic Burden Better Explain Sex Differences in Functional Impairments Than Apnoea‐Hypopnoea Index in Obstructive Sleep Apnoea?

Journal of Sleep Research, EarlyView.
ABSTRACT Women with obstructive sleep apnoea (OSA) report more severe functional impairments than men, despite lower apnoea‐hypopnoea index (AHI) values. This raises questions about the adequacy of AHI for capturing OSA severity. We explored sex differences in functional outcomes in OSA patients and examined whether AHI or hypoxic burden (HB) better ...
Urvashi Nanda, Yu Sun Bin, Philip de Chazal, Andrew S. L. Chan, Amanda Piper, Kristina Kairaitis, Peter A. Cistulli, Brendon J. Yee, on behalf of the Sydney Sleep Biobank Investigators, Peter Cistulli, Philip de Chazal, Yu Sun Bin, Lu Fu, Benjamin Tong, Glenn Stewart, Gary Cohen, Andrew S. L. Chan, Anna Mohammadieh, John Wheatley, Kristina Kairaitis, Stephen Lambert, Tracey Burns, Brendon Yee, Amanda Piper, Kerri Melehan, Amy Jackson, Gislaine Gauthier   +26 more
wiley   +1 more source

Association of diuretics with falls and wrist fractures: a Mendelian randomization study

Frontiers in Public Health
BackgroundThe association between diuretics and falls in older adult has been reported in previous studies, but discrepancy remains between the different types of diuretics.
Fei Liu, Jun-ze Dai, Xiao-xi Deng, Ren-shuang Cao, Yong-zhong Cheng, Chao-lu Wang   +5 more
doaj   +1 more source

Inpatient Cardiac Resynchronization Therapy During Heart Failure Hospitalization: A Distinct High‐Risk Phenotype

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background The role of cardiac resynchronization therapy (CRT) during hospitalization for heart failure (HFH) is uncertain, because hospitalized patients were routinely excluded from landmark CRT trials. Despite this, CRT implantation during HFH is common.
Oliver Rees, James Dargan, Jemima Weir, Robin Ray, Giuseppe Rosano, Fadi Johura   +5 more
wiley   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

The Paradox of Hypertonic Saline Infusion for Patients with Heart Failure

Cardiorenal Medicine
Background: Fluid/sodium overload is the primary reason for hospital admission for patients with acute decompensated heart failure. Unfortunately, congestion often remains undertreated and is associated with significant adverse outcomes in ...
Negiin Pourafshar, Siddharth S. Madapoosi, Ashkan Karimi, Jeffrey Testani, Christopher S. Wilcox   +4 more
doaj   +1 more source