Results 81 to 90 of about 633,245 (221)

Trajectory of macrotroponin in a community cohort

Internal Medicine Journal, EarlyView.
Abstract Background Cardiac troponin I (cTnI) is a biomarker for myocardial injury. However, macrotroponin, a complex of cTnI and endogenous cardiac troponin autoantibodies, may artefactually elevate cTnI levels with potential to mislead clinicians, leading to inappropriate investigation and management.
Duncan J. Campbell, Fei Fei Gong, Michele McGrady, David L. Prior, Christopher M. Reid, Christina M. Trambas   +5 more
wiley   +1 more source

Cardiovascular preventive role of thiazolidinedione in patients with type 2 diabetes mellitus undergoing percutaneous coronary intervention

Journal of Diabetes Investigation, EarlyView.
Among patients with type 2 diabetes undergoing percutaneous coronary intervention, thiazolidinedione use was independently associated with a significantly reduced risk of a composite of myocardial infarction, stroke, and all‐cause death, notably without an increased risk of admission for heart failure. ABSTRACT Background Thiazolidinediones (TZD) are a
Jinkwon Kim, Jimin Jeon, Joonsang Yoo, Minyoul Baik, Seok‐Jae Heo, Ji Woong Roh   +5 more
wiley   +1 more source

Temporal distribution of acute kidney injury–related hospitalizations after initiation of sodium–glucose cotransporter 2 inhibitors: A nationwide claims database analysis in older adults with an independent complementary single‐center eGFR analysis

Journal of Diabetes Investigation, EarlyView.
Among 190 older adults who experienced AKI‐related hospitalization after SGLT2 inhibitor initiation, 31.1% were hospitalized within 30 days. In an independent single‐center cohort, sustained early eGFR decline was associated with older age and use of one or two triple‐whammy‐related drug classes.
Kazuya Hiura, Ayana Tatsuno, Yamato Noto, Ryosuke Wakamatsu, Masayuki Sakunami, Ryu Kobayashi, Miki Yamashita   +6 more
wiley   +1 more source

SGLT2i use and fracture risk compared with DPP4i in patients with T2DM

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction The association between sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) use and fracture risk remains inconclusive. Most previous studies have focused on treatment‐naïve patients, despite many patients in routine clinical practice initiating SGLT2i therapy after prior dipeptidyl peptidase‐4 inhibitor (DPP4i) use.
Sung‐Yen Lin, Shih‐Hao Huang, Ching‐Han Chiang, Cheng‐Jung Ho, Chung‐Hwan Chen, Li‐Nien Chien   +5 more
wiley   +1 more source

Loop diuretics, heart failure diagnosis and outcome in primary care [PDF]

BackgroundLoop diuretics are commonly prescribed in primary care. We explored HF assessment, diagnosis, and outcomes following a loop diuretic prescription.Methods & resultsThe Clinical Practice Research Datalink Gold database linked to Hospital ...
Turgoose, J, Lomax, S, Taylor, Clare; id_orcid, Clark, A L, Cuthbert, J J, Soyiri, I, Cohen, J, Fuat, Ahmet, Luo, E   +8 more
core   +1 more source

Hip Fracture Risk of Lemborexant and Suvorexant in Comparison With Z‐Drugs: A Target Trial Emulation

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Lemborexant and suvorexant are widely used dual orexin receptor antagonists (DORAs) for the pharmacological treatment of insomnia. Although they are generally considered safer than benzodiazepine receptor agonists (Z‐drugs) regarding adverse events including hip fractures, evidence from direct comparisons remains limited. This study
Yuichiro Matsuo, Hayato Yamana, Yusuke Sasabuchi, Hiroki Matsui, Takahide Kohro, Hideo Yasunaga   +5 more
wiley   +1 more source

Identification and Treatment of Anorexia Nervosa in Women With Perimenopause

Journal of Midwifery &Women's Health, EarlyView.
Abstract Disordered eating is a common problem that midwives will encounter as frontline primary care providers. Anorexia nervosa (AN) is a form of disordered eating that results in chronic starvation state, creating significant risk of morbidity and mortality to the patient. AN is traditionally considered a disorder of adolescence and young adulthood;
Janell Senda, Sarah Carpenter, Mary Carter‐Orbke   +2 more
wiley   +1 more source

Effect of Sotagliflozin on Kidney Function and Cardio‐Kidney‐Metabolic Parameters Across Baseline eGFR Subgroups in Patients With Type 2 Diabetes and Stage 4 CKD

Diabetes, Obesity and Metabolism, EarlyView.
Vikas S. Sridhar, Luxcia Kugathasan, Manon Girard, Michael J. Davies, David Z. I. Cherney   +4 more
wiley   +1 more source

Prevalence and Characteristics of Urinary Catheter Blockage in Patients With Long‐Term Urinary Catheterization: A Cross‐Sectional Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims To determine the prevalence and characteristics of urinary catheter blockage in older patients using objective indicators and to characterize obstructive materials and microbiota. Design A cross‐sectional study. Methods Patients aged ≥ 65 years with an indwelling catheter for ≥ 24 h were recruited from a long‐term care hospital.
Natsumi Hirose, Mao Kunimitsu, Chihiro Takizawa, Yukie Kataoka, Minami Shinkawa, Chika Takada, Atsuo Kawamoto, Jun Kamei, Haruki Kume, Chizuko Konya, Hiromi Sanada, Gojiro Nakagami   +11 more
wiley   +1 more source

High urine osmolality and elevated urine sodium predict early nonresponse to fluid restriction in patients with the syndrome of inappropriate antidiuresis

Journal of Internal Medicine, EarlyView.
Abstract Introduction Fluid restriction is the current first‐line therapy for hyponatremia induced by the syndrome of inappropriate antidiuresis (SIAD), yet up to 50% of patients do not achieve an adequate plasma sodium correction. Reported predictors of nonresponse include urine osmolality >500 mOsm/kg, the Furst ratio >1 [(UNa + UK)/(PNa)], urine ...
Michelle Patricia Müller, Laura Potasso, Ewout J. Hoorn, Julie Refardt, Mirjam Christ‐Crain, for the HIT study investigators   +5 more
wiley   +1 more source