Results 111 to 120 of about 25,138 (263)
Hypersensitivity to Excipients in Drugs: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey +10 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen +3 more
wiley +1 more source
Loop diuretics, heart failure diagnosis and outcome in primary care [PDF]
BackgroundLoop diuretics are commonly prescribed in primary care. We explored HF assessment, diagnosis, and outcomes following a loop diuretic prescription.Methods & resultsThe Clinical Practice Research Datalink Gold database linked to Hospital ...
Turgoose, J +8 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
Diuretics: A Clinical and Pharmacological Review
This thesis provides a comprehensive review from clinical and pharmacological perspectives on diuretics, with a primary focus on their role in managing cardiovascular diseases.
Chu, Ying Ju
core
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Introduction Pharmacokinetic data suggest a potential dose‐dependent effect of sodium–glucose co‐transporter‐2 (SGLT‐2) inhibitors on surrogate markers of efficacy, but the impact of SGLT‐2 inhibitor dose on renal and cardiovascular outcomes remains uncertain.
Elias John Elenjickal +5 more
wiley +1 more source
Combining Loop and Thiazide Diuretics Across the Left Ventricular Ejection Fraction Spectrum: The CLOROTIC Trial [PDF]
Background: The addition of hydrochlorothiazide (HCTZ) to furosemide in the CLOROTIC (Combining Loop with Thiazide Diuretics for Decompensated Heart Failure) trial improved the diuretic response in patients with acute heart failure (AHF).
Manzano Espinosa, Luis +24 more
core +1 more source
Congestion, decongestion, renal function and diuretics in (ESC) heart failure
ESC Heart Failure, Volume 12, Issue 2, Page 730-732, April 2025.
Jan Biegus +2 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Urogenital adverse events are common with sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) and may influence treatment decisions. Variations in SGLT2i selectivity, potency and effects on renal glucose excretion could lead to differences in safety profiles. We compared the risks of urinary tract infection (UTI), genital tract infection (
Christine Ljungberg +7 more
wiley +1 more source
Pharmacokinetics of torasemide and its metabolites in end-stage renal disease
, 1994 The pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v.
Schwab, A. +5 more
core +1 more source