Results 101 to 110 of about 9,816 (262)

Analysis of topological organization of chromatin during spermatogenesis in mouse testis

Genetics and Molecular Biology, 2004
Eukaryotic chromatin is organized as radial DNA loops with periodical attachments to an underlying nucleoskeleton known as nuclear matrix. This higher order chromatin organization is revealed upon high salt extraction of cells.
Narayan Gopeshwar, Raman Rajiva
doaj  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

A Fuzzy Framework for Managing Supply Chain Disruptions and Uncertainties via Aperiodic Time-Dependent Nonfragile Sampled-Data Control With Communication Delays

IEEE Access
This article investigates fuzzy frameworks for analyzing the stability and stabilization of nonlinear supply chain systems (SCSs) affected by external disturbances and uncertainties.
Nivetha Thirumalairaj Kannadasan, Aruna Polisetty   +1 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Failed Loop Endobutton Acromioclavicular Joint Reconstruction Treated with Duo Figure of 8 FiberTape Augmented Autogenic Graft Wrapping Technique: A Case Report

Journal of Orthopaedic Case Reports
Introduction: Acromioclavicular joint (ACJ) injuries are prevalent among young, active individuals and account for a significant proportion of shoulder girdle and collision sports injuries.
Saurabh Singh, Sushit Kumar Sonu, Rahul Patel, Kumar Prashant, Himanshu Nagar   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The environmental adaptation of acidophilic archaea: promotion of horizontal gene transfer by genomic islands

BMC Genomics
Acid mine drainage (AMD) is an extremely acidic leachate highly contaminated with metal ions, yet it harbors a significantly high abundance of archaea. Genomic islands (GIs), as one of the productions of horizontal gene transfer (HGT), play an important ...
Jingxuan Qiu, Huiling Tao, Hongyu Li, Xinyi Liu, Rui Liu, Muhammed Naveed Nawaz, Xingjie Wang, Liyuan Ma   +7 more
doaj   +1 more source

State Estimation-Based Disturbance Rejection Control for Third-Order Fuzzy Parabolic PDE Systems with Hybrid Attacks

Mathematics
In this work, we develop a disturbance suppression-oriented fuzzy sliding mode secured sampled-data controller for third-order parabolic partial differential equations that ought to cope with nonlinearities, hybrid cyber attacks, and modeled disturbances.
Karthika Poornachandran, Elakkiya Venkatachalam, Oh-Min Kwon, Aravinth Narayanan, Sakthivel Rathinasamy   +4 more
doaj   +1 more source