Results 81 to 90 of about 3,094,835 (251)

Equation of State of Looped DNA [PDF]

, 2007
We derive the equation of state of DNA under tension that features a loop. Such loops occur transiently during DNA condensation in the presence of multivalent ions or permanently through sliding protein linkers such as condensin.
Mohrbach, Hervé, THAOKAR, R, Thaokar, Rochish, KULIC, IM, Schiessel, Helmut, Kulić, Igor M., MOHRBACH, H, SCHIESSEL, H   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Reliability assessment of water distribution systems with statistical entropy and other surrogate measures [PDF]

, 2010
There is ever increasing commercial and regulatory pressure to minimise the cost of water distribution networks even as the demand for them keeps on growing. But cost minimizing is only one of the demands placed on network design.
Tanyimboh, Tiku T., Tietavainen, Marika T., Saleh, Salah, Saleh Saleh, Tiku T. Tanyimboh, Marika T. Tietavainen   +5 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Measuring exotic looped trajectories of light

, 2014
The probability of a photon to follow looped trajectories in a three-slit interferometer is extremely small and difficult to measure.
Magaña-Loaiza, Omar S., Rodenburg, Brandon, Boyd, Robert W., De Leon, Israel, Mirhosseini, Mohammad, McIntyre, Brian   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Comparative renal physiology and excretory adaptations in ruminants and poultry: Implications for nutrition, health, and environmental management

Poultry Science
The urinary systems of ruminants and poultry represent an evolutionary adaptation to distinct ecological niches, digestive strategies, and water conservation needs.
Dawudie Gobezie
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

DFNets: Spectral CNNs for graphs with feedback-looped filters

, 2023
We propose a novel spectral convolutional neural network (CNN) model on graph structured data, namely Distributed Feedback-Looped Networks (DFNets). This model is incorporated with a robust class of spectral graph filters, called feedback-looped filters,
Wijesinghe, Asiri, Wang, Qing
core