Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer. [PDF]
In preclinical studies, selenite had single agent activity and radiosensitized tumors in vivo. Here we report results from a Phase 1 trial in 15 patients with metastatic cancer treated with selenite (5.5 to 49.5 mg) orally as a single dose 2 hours before
Buyyounouski, Mark K +9 more
core
Fluoroquinolone antibiotic users select fluoroquinolone-resistant ESBL-producing Enterobacteriaceae (ESBL-PE) - Data of a prospective traveller study [PDF]
Background: One third of travellers to the poor regions of the (sub) tropics become colonized by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE).
Kantele, Anu +3 more
core +1 more source
Effect of Flammulina velutipes (golden needle mushroom, eno-kitake) polysaccharides on constipation
Flammulina velutipes, (Curt. ex Fr.) Sing, a popularly edible fungus, has been widely used both as a restorative drug and a tonic food in China. In the current study, the effect of F.
Xin Xin +4 more
doaj +1 more source
Antimicrobial drug treatment of travelers’ diarrhea is known to increase the risk for colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae.
Anu Kantele +3 more
doaj +1 more source
ABSTRACT Objective To describe the clinical signs and outcome of a ferret with cannabinoid toxicosis diagnosed with an over‐the‐counter urine tetrahydrocannabinol test and treated with intravenous lipid emulsion (ILE). Case Summary A 1‐year‐old spayed female ferret was admitted for evaluation of abnormal mentation after being found vocalizing under a ...
Claudia Huerta +3 more
wiley +1 more source
Novel insights into mechanisms of inhibition of colonic motility by loperamide
BackgroundIt is well known that opiates slow gastrointestinal (GI) transit, via suppression of enteric cholinergic neurotransmission throughout the GI tract, particularly the large intestine where constipation is commonly induced. It is not clear whether
Nabil Parkar +11 more
doaj +1 more source
Structure‐based discovery of thiamine uptake inhibitors
Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel +2 more
wiley +1 more source
Current trends in the management of childhood gastroenteritis in the community [PDF]
Infection of the gastrointestinal tract are still amongst the most common infections of childhood. Despite improvements in the standard of living over the last fifty years, gastroenteritis still constitutes a sizeable amount of general practitioner ...
Vella, Cecil
core
Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice [PDF]
BACKGROUND: Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments.
Ojha, Sudarshan +2 more
core +2 more sources
Abstract The antidiarrhoeal effect of loperamide is caused by its antimotility and antisecretory properties. In-vivo experiments in the rat jejunum and colon have been performed to compare the antisecretory effect of loperamide with the effect of its prodrug, loperamide oxide.
Eckhard Beubler, Pramila Badhri
openaire +3 more sources

