Results 91 to 100 of about 23,058 (301)

P-glycoprotein and its role in drug-drug interactions [PDF]

, 2014
Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption. Drugs which induce P-glycoprotein, such as rifampicin, can reduce
Finch, Andrew, Pillans, Peter
core   +1 more source

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

Journal of Small Animal Practice, EarlyView.
This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley   +1 more source

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

Loperamide [PDF]

Journal of Pain and Symptom Management, 2011
Claud, Regnard, Robert, Twycross, Mary, Mihalyo, Andrew, Wilcock   +3 more
openaire   +3 more sources

Dorsal Genital Nerve Stimulation in Patients With Fecal Incontinence and Fecal Urgency: A Feasibility Study With the Novel UCon Neurostimulator

Neurogastroenterology &Motility, EarlyView.
Dorsal genital nerve stimulation with the UCon neurostimulator was found to be safe and feasible. A 4‐week period of home stimulation resulted in a reduction of fecal incontinence episodes, a decrease in strong urgency episodes, and an improvement in bowel‐related questionnaires.
Louise Schmidt Grau, Peter Christensen, Niels Qvist, Niels Klarskov, Nico Rijkhoff, Jakob Duelund‐Jakobsen   +5 more
wiley   +1 more source

Increased Risk for ESBL-Producing Bacteria from Co-administration of Loperamide and Antimicrobial Drugs for Travelers’ Diarrhea

Emerging Infectious Diseases, 2016
Antimicrobial drug treatment of travelers’ diarrhea is known to increase the risk for colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae.
Anu Kantele, Sointu Mero, Juha Kirveskari, Tinja Lääveri   +3 more
doaj   +1 more source

The pattern of symptoms in patients receiving home based care in Bangwe, Malawi : a descriptive study [PDF]

, 2006
BackgroundHome based care of HIV/AIDS patients is a health need recommended but not often available in Africa. Population based assessment helps to identify unmet health needs to plan services.
Cameron Bowie, Claire Bowie, Linda Kalilane, Paul Cleary   +3 more
core   +2 more sources

Loperamide and P‐glycoprotein modulator in opioid detoxification [PDF]

, 2021
Mohamed Al Garhy, Sona Mohan, Aisha Al Dhufairi   +2 more
openalex   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Worldwide Efficacy of Bismuth Subsalicylate in the Treatment of Travelers' Diarrhea [PDF]

, 2017
So far four randomized studies, three of them double-blind and placebo-controlled, have investigated the role of bismuth subsalicylate (BSS) in the treatment of travelers' diarrhea.
Steffen, Robert
core