Results 91 to 100 of about 31,170 (214)

Angiotensin receptor blocker losartan inhibits tumor growth of colorectal cancer

, 2021
The renin-angiotensin system (RAS) is up-regulated in patients with colorectal cancer (CRC) and is reported to be associated with poor prognosis and chemo-resistance.
Reyhaneh Moradi-Marjaneh (16266725), Atena Soleimani (16267658), Mohieddin Jafari (1426771), Seyed Mahdi Hassanian (16040378), Fereshteh Asgharzadeh (14501558), Gordon Ferns (4464037), Majid Khazaei (14501567), Farnaz Barneh (1426768), Mahdieh Khoshakhlagh (16285649), Mikhail Ryzhikov (16266323), Milad Hashemzehi (16278341), Hamid Fiuji (16248560), Farzad Rahmani (9742755), Amir Avan (121170)   +13 more
core   +1 more source

Influence of losartan on the hypoglycemic activity of glimepiride in normal and diabetic rats

Therapeutic Advances in Endocrinology and Metabolism, 2013
Background: The influence of losartan on the hypoglycemic effect of glimepiride was studied in normal and diabetic rats. Method: Losartan and glimepiride were studied at a dose of 4.5 and 0.09 mg/kg and in normal and diabetic rats, respectively.
T.E.G.K. Murthy, Manogna K. Kommineni, Candasamy Mayuren   +2 more
doaj   +1 more source

Isolated Gamma‐Glutamyltransferase Elevation During Statin Therapy: A Diagnostic Pitfall and a Stepwise Management Framework to Prevent Unnecessary Discontinuation

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT The management of patients with isolated gamma‐glutamyltransferase (GGT) elevation during statin therapy remains a common clinical dilemma due to the unclear relevance to hepatotoxicity. We report a case of a patient with coronary artery disease who developed persistent isolated GGT elevation (> 100 U/L) while on atorvastatin, with normal ...
Jun Yang, Yanling He, Zhengyong Zhang
wiley   +1 more source

Comparative effectiveness of a fixed-dose combination of losartan + HCTZ versus bisoprolol + HCTZ in patients with moderate-to-severe hypertension: results of the 6-month ELIZA trial

, 2013
GD Radchenko, YM Sirenko, SM Kushnir, OO Torbas, AS DobrokhodSecondary Hypertension Department, National Scientific Center, Strazhesko Institute of Cardiology, Kiev, UkraineBackground: The aim of this study was to compare the antihypertensive efficacy of
Torbas OO, Sirenko YM, Dobrokhod AS, Radchenko GD, Kushnir SM   +4 more
core  

Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials

Cardiology and Therapy, 2019
Introduction The role of losartan in preventing aortic root dilatation in Marfan syndrome has been evaluated in many clinical trials; however, the results are conflicting.
Ayman Elbadawi, Mohamed A. Omer, Islam Y. Elgendy, Ahmed Abuzaid, Ahmed H. Mohamed, Devesh Rai, Marwan Saad, Amgad Mentias, Ahmed Rezq, Diaa Kamal, Wissam Khalife, Barry London, Mohamed Morsy   +12 more
doaj   +1 more source

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, Volume 28, Issue 3, Page 855-867, June 2026.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Overload-induced angiogenesis is not altered by losartan treatment.

, 2014
Representative inverted grey scale images of iso-lectin staining (A) were used to calculate capillary to muscle fiber ratio (n = 4 per condition) (B). In (C), VEGF protein levels were assessed by Western blotting with expression normalized to ß-actin (n =
Sammy T. K. Liu (131272), Jennifer L. Gorman (507705), Dara Slopack (507706), I. Mark Olfert (70758), Adam Hasanee (507708), Sara Olenich (507709), Khashayar Shariati (507707), Tara L. Haas (131300)   +7 more
core   +1 more source

Genetic Bone Diseases: A Scoping Review of Pathology, Symptoms, Diagnosis, Treatment, and New Horizons

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review highlights six genetic diseases of the bone, aiming to provide clinicians and researchers with updated information on their diagnosis and treatment. It also includes an assessment of common clinical and radiographic findings, along with pathophysiology related to diseases.
Colin Jones, Ambalangodage C. Jayasuriya
wiley   +1 more source

Chronic treatment with Losartan and cerebral ischemic tolerance.

, 2009
Clinical trials have suggested that Losartan has beneficial effects on preventing stroke beyond its antihypertensive properties. Although there is evidence for Losartan reducing ischemic damage following a highly localized type of stroke, its role in ...
Zhao, Zonghang, Tuor, Ursula I., Barber, Phil   +2 more
core   +1 more source

Impact of Prior Angiotensin‐Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use on Delirium Incidence in ICU Patients: A Retrospective Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims This investigation aimed at exploring the impact that the pre‐existing use of angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) has on the incidence of delirium in patients within the intensive care unit (ICU).
Zhe Li, Shuo Liu, Qihai Wan, Yahui Niu, Yi Yu   +4 more
wiley   +1 more source