Results 101 to 110 of about 31,170 (214)

Investigation of the curative effect of losartan on the diabetes mellitus by GC-based metabonomics

, 2007
The aim of the study was to assess the feasibility of metabonomics in clinical studies and the curative effect of drug. It is projected that type 2 diabetes will be the biggest killer in the western world by 2020.
袁凯龙, 许国旺, 高鹏, 史春云, 路鑫   +4 more
core  

A Robust and Universal LC–MS/MS Method for Determination of N‐Nitrosodimethylamine in Pharmaceuticals Using a C30 Column

Journal of Separation Science, Volume 49, Issue 6, June 2026.
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An, Unyong Kim, Sumin Seo, Jiyu Kim, Chohee Jeong, Woojin Jeong, Eunjin Ko, Juhyeon Kim, Hyun‐Deok Cho, Sang Beom Han   +9 more
wiley   +1 more source

Biphasic effects of losartan potassium on immobility in mice [PDF]

, 2005
The effects of losartan potassium, an angiotensin AT, receptor blocker on immobility in forced swim test have been studied. Effect of losartan potassium, nortriptyline HCl, fluoxetine, HCl and reserpine per se and in combination on forced swimming ...
Vijayapandi, P., Nagappa, A.N.
core  

The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats

Clinical and Experimental Hypertension, 2018
The objective of the present study was to investigate the effects of single and combined administration of ramipril and losartan on renal structure and function in spontaneously hypertensive rats (SHRs). Thirty-two 9-week-old SHRs and eight Wistar-Kyoto (
Lin Yun, Xingshun Xu, Ying Dai, Rui Xu, Guohua Li, Yucai Yao, Jiamin Li, Fei Zheng   +7 more
doaj   +1 more source

Fibroids in obstructed hemivagina and ipsilateral renal anomaly‐like syndrome: Successful hysterectomy and vaginal septoplasty in a kidney transplant recipient with uterus didelphys, vaginal septum and renal agenesis

International Journal of Gynecology &Obstetrics, Volume 174, Issue 1, Page 491-493, July 2026.
Mariana Correia Moreira Cruz, Sophia Helena Batalha, Vitor Matheus Silva, Marcos de Lorenzo Messina, José Maria Soares Junior, Edmund Chada Baracat   +5 more
wiley   +1 more source

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Trajectories of Treatment Disruption for Chronic Outpatient Medications for U.S. Veterans During Drug Shortages

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Introduction Although drug shortages for outpatient chronic conditions commonly occur, population‐level data on how they impact patients' ability to refill prescriptions is scarce. We sought to identify distinct patterns of refill adherence following drug shortages and patient‐ and prescription‐level factors associated with adherence ...
Katie J. Suda, Xinhua Zhao, Sherrie L. Aspinall, Yaming Li, Katherine Callaway Kim, Francesca E. Cunningham, Taylor L. Boyer, Tate W. Miner, Clara Kima, Walid F. Gellad, Peter A. Glassman, Chester B. Good, Felicia Skelton, Mina Tadrous, Carolyn T. Thorpe   +14 more
wiley   +1 more source

Modeling the Influence of CYP2C9 and ABCB1 Gene Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Losartan

Pharmaceutics
Background/Objectives: Hypertension is a pathological condition characterized by elevated systolic and/or diastolic blood pressure. A range of pharmacotherapeutic agents are available to treat this condition and prevent complications, including the ...
Dmitry Babaev, Elena Kutumova, Fedor Kolpakov   +2 more
doaj   +1 more source

Angiotensin II Receptor Antagonists: The Prototype Losartan

, 1996
ObjectiveTo describe a new class of antihypertensive agents, the angiotensin II receptor antagonists, with emphasis on the prototype losartan. Pharmacokinetic data and clinical trials are reviewed, as well as adverse reactions, drug interactions, and ...
Karen L Schaefer, Maria Rudis, Julie A Porter, Brenda R Morand   +3 more
core   +1 more source