Results 61 to 70 of about 33,513 (195)
Expert Approaches to the Assessment of Losartan Drugs Bioequivalence
Регуляторные исследования и экспертиза лекарственных средств, 2020 Angiotensin II receptor antagonists (ARAs) are one of the most promising classes of antihypertensive drugs. They are most widely represented on the Russian market by losartan drugs which total 24 items.
D. P. Romodanovsky, D. V. Goryachev
doaj +1 more source
Considerations for drug trials in hypertrophic cardiomyopathy
ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant +17 more
wiley +1 more source
Advanced Science, 2022 Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration and efficacy. Herein,
Suchen Bian +12 more
doaj +1 more source
FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts
European Journal of Organic Chemistry, EarlyView.An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya +2 more
wiley +1 more source
Effect of losartan in treatment of exercise-induced myocardial ischemia.
, 2007 Because no controlled clinical studies are available about the possible role of angiotensin II receptor blockers in preventing effort myocardial ischemia, we evaluated the effect of angiotensin II receptor blocker/losartan in preventing exercise ...
Longobardi G +7 more
core +2 more sources
Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. [PDF]
PLoS ONE, 2015 PURPOSE:To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice.
Harry A Quigley +12 more
doaj +1 more source
WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse
Epilepsia, EarlyView.Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper +11 more
wiley +1 more source
PLoS ONE, 2015 Inhibition of angiotensin II type 1 receptor (AT1R) is an important therapy in the management of hypertension, particularly in the immediate post-myocardial infarction period.
Minwoo A Song +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2010 Ca2+-activated K+ (K Ca ) channels are important for endothelium-derived hyperpolarizing factor (EDHF) signaling. Since treatment with angiotensin II receptor blockers (ARBs) improves vasculopathies in type 2 diabetic patients, we asked whether the EDHF ...
Takayuki Matsumoto +4 more
doaj +1 more source
Medicine Bulletin, EarlyView.Allisartan ranked best for serum urate reduction and showed favourable blood pressure control, whereas losartan also performed well overall. These rankings may inform ARB selection but should be interpreted cautiously because of inconsistency, heterogeneity and sparse direct evidence.
Xuanyao Li +5 more
wiley +1 more source