Results 41 to 50 of about 33,513 (195)

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Effects of gut microbiota dysbiosis on the metabolism and pharmacokinetics of losartan in rats: from endogenous to ceftriaxone-induced dysbiosis

Frontiers in Microbiology
IntroductionGut microbiota plays a key role in drug metabolism. While gut microbiota dysbiosis is known to contribute to hypertension pathogenesis, its impact on drug metabolism remains poorly considered.
Jiaxuan Xia, Jiaxuan Xia, Jiaxuan Xia, Yibao Jin, Yanjun Hong, Yuefeng Zhang, Meifang Li, Houshuang Huang, Xu Cai, Dan Li, Bing Wang, Zhiyong Xie   +11 more
doaj   +1 more source

Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension

Brazilian Journal of Medical and Biological Research, 2002
Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats.
A.M. Sugawara, R.C. Vendramini, S.P. Barbosa, I.L. Brunetti, J.V. Menani, L.A. De Luca Jr.   +5 more
doaj   +1 more source

Losartan Alleviates Renal Fibrosis and Inhibits Endothelial-to-Mesenchymal Transition (EMT) Under High-Fat Diet-Induced Hyperglycemia

Frontiers in Pharmacology, 2018
The endothelial-to-mesenchymal transition (EMT) of glomerular vascular endothelial cells is considered to be pivotal in diabetic nephropathy (DN).
Yufeng Yao, Yong Li, Xiaofei Zeng, Zheng Ye, Xia Li, Lu Zhang   +5 more
doaj   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Losartan-induced hepatic injury

, 2002
Losartan, an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. Clinical experience with this drug has demonstrated that it is safe. Losartan-induced hepatic toxicity is extremely rare.
Ozaras, Reşat, Mert, Ali, Tabak, F, Ozturk, Recep, AKTUĞLU, Yıldırım, Bıyıklı, Mithat, Senturk, Hakan, Ozbay, Gülşen   +7 more
core   +1 more source

Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9

Фармакокинетика и Фармакодинамика, 2020
The role of cytochrome P450 isoforms CYP2C9 and in the metabolism of losartan described. Losartan pharmacokinetics data in humans and laboratory animals are presented.
O. G. Gribakina, G. B. Kolyvanov, A. A. Litvin, A. O. Viglinskaya, V. P. Zherdev   +4 more
doaj  

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Effects of Metformin and Losartane on Hepatic Cytochromes CYP3А, CYP2С and CYP2Е1 Functioning at Metabolic Syndrome in Rats

Innovative Biosystems and Bioengineering
Background. The study of drugs' possible metabolic and biological interactions in preclinical models is a necessary condition for improving the development of most combinations of medicines. Objective.
Larysa Bondarenko, Ganna Shayakhmetova, Alla Voronina, Valentyna Kovalenko   +3 more
doaj   +1 more source

Different initiatives across Europe to enhance losartan utilisation post generics: impact and implications

Frontiers in Pharmacology, 2014
Introduction: There is an urgent need for health authorities across Europe to fully realise potential savings from increased use of generics to sustain their healthcare systems.
James eMoon, Brian eGodman, Brian eGodman, Max ePetzold, Samantha eAlvarez-Madrazo, Kathleen eBennett, Iain eBishop, Anna eBucsics, Ulrik eHesse, Andrew eMartin, Steven eSimoens, Corinne eZara, Rickard E Malmstrom   +12 more
doaj   +1 more source