Results 31 to 40 of about 33,513 (195)

Effects of oral losartan administration on homeostasis of articular cartilage and bone in a rabbit model

Bone Reports, 2022
Background and aims: Previous work has shown that oral losartan can enhance microfracture-mediated cartilage repair in a rabbit osteochondral defect injury model.
Zhenhan Deng, Xueqin Gao, Hajime Utsunomiya, Justin W. Arner, Joseph J. Ruzbarsky, Matthieu Huard, Sudheer Ravuri, Marc J. Philippon, Johnny Huard   +8 more
doaj   +1 more source

Losartan Monotherapy vs Combination Regimens in IgA Nephropathy: A Systematic Review and Network Meta-analysis

ASIDE Internal Medicine
Background: IgA nephropathy (IgAN) is a disorder in which Immunoglobulin A (IgA) antibodies build up, causing kidney damage. Losartan, an Angiotensin Receptor Blocker (ARB), has shown promise in patients with IgAN. However, a comparison of losartan with
Mohamed E. Haseeb, Hazem E. Mohammed, Anas Hussein Heiba, George Hanen, Nada Ali Omar Abd Elaziz, Mohamed Nasser   +5 more
doaj   +1 more source

Losartan in Marfan syndrome [PDF]

, 2017
Marfan syndrome (MFS) is a multisystemic disorder of the connective tissue with a prevalence of 1 per 5000 and is caused by mutations in the FBN1 gene.
den Hartog, A.W.
core   +6 more sources

Comparison of the efficacy and safety of fixed-dose amlodipine/losartan and losartan in hypertensive patients inadequately controlled with losartan: a randomized, double-blind, multicenter study

, 2012
BACKGROUND: Fixed-dose combination drugs may enhance blood pressure (BP) goal attainment through complementary effects and reduced side effects, which leads to better compliance. OBJECTIVE: This study aimed to evaluate the efficacy and safety profiles
Hong, BK, Yoon, HJ, Choi, YJ, Park, CG, Yoon, MH, Yang, JY, Cho, SY, Kim, KS, Yoon, JH   +8 more
core   +2 more sources

Effects of losartan combined with exercise training in spontaneously hypertensive rats

Brazilian Journal of Medical and Biological Research, 2003
We investigate whether combined treatment with losartan, an angiotensin II receptor blocker, and exercise training (ET) in spontaneously hypertensive rats (SHR) would have an additive effect in reducing hypertension and improving baroreflex sensitivity ...
L.F. Azevedo, P.C. Brum, K.C. Mattos, C.M. Junqueira, M.U.P.B. Rondon, A.C.P. Barretto, C.E. Negrao   +6 more
doaj   +1 more source

Losartan protects against osteoarthritis by repressing the TGF-β1 signaling pathway via upregulation of PPARγ

Journal of Orthopaedic Translation, 2021
Objective: Losartan and activation of the peroxisome proliferator-activated receptor-γ (PPARγ) have been previously reported to alleviate the progression of osteoarthritis (OA).
Zhenhan Deng, MD, Ph.D, Fei Chen, Ph.D, Yuwei Liu, MD, Ph.D, Jinping Wang, Ph.D, Wei Lu, MD, Ph.D, Wei Jiang, MD, Ph.D, Weimin Zhu, MD, Ph.D   +6 more
doaj   +1 more source

Oxadiazolone-Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II-Induced Vascular Contraction. [PDF]

ChemMedChem
A novel series of candidate AT1 receptor antagonists based on oxadiazolone‐triazole scaffolds was designed and synthesized. Most compounds reduced angiotensin II‐induced vascular contraction in an initial biological screening, with compound 7f emerging as the most active derivative.
Ferreira LFL, Vasconcelos DGA, Santos RCA, Ferreira JG, Araújo AV, Anjos JVD.   +5 more
europepmc   +2 more sources

Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats

Data in Brief, 2017
We describe the effects of losartan, a selective AT1 receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled “Angiotensin type 1 receptor mediates chronic ethanol ...
Carla S. Ceron, Gabriel T. do Vale, Janaina A. Simplicio, Patrícia Passaglia, Sthefany T. Ricci, Carlos R. Tirapelli   +5 more
doaj   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men

Frontiers in Neuroscience, 2020
Components of the renin-angiotensin system (RAS) situated within the carotid body or central nervous system may promote hypoxia-induced chemoreceptor reflex sensitization or central sleep apnea (CSA).
Courtney V. Brown, Lindsey M. Boulet, Tyler D. Vermeulen, Scott A. Sands, Richard J. A. Wilson, Najib T. Ayas, Najib T. Ayas, John S. Floras, Glen E. Foster   +8 more
doaj   +1 more source