Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells [PDF]
Applied Sciences, 2021 Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human ...
Babak Saravi +12 more
doaj +3 more sources
Losartan Inhibits SARS-CoV-2 Replication in Vitro [PDF]
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus.
Reza Nejat +6 more
doaj +2 more sources
Arquivos Brasileiros de Cardiologia, 2000 OBJECTIVE: To compare the regression of left ventricular hypertrophy in patients with moderate hypertension treated with enalapril, losartan or a combination of the two drugs at lower doses.
Antônio Carlos Avanza Jr +2 more
doaj +2 more sources
Cardiology and TherapyIntroduction Cardiovascular diseases are a leading cause of global mortality, with hypertension as a major risk factor. Low control rates are often attributed to monotherapy, while evidence and clinical guidelines support the effectiveness of combination
Isabel E. Rucker-Joerg +8 more
doaj +2 more sources
Correction to "Losartan Enhances Radiosensitivity by Reversing Immunosuppressive Tumor Microenvironment Induced by Radiotherapy in TNBC". [PDF]
Cancer SciCancer Science, EarlyView.
europepmc +2 more sources
Losartan reverses impaired osseointegration in spontaneously hypertensive rats. [PDF]
, 2018 OBJECTIVE Hypertension is not only associated with cardiovascular diseases but also with alterations in bone quality. Hypertension therefore might be a risk factor for osseointegration.
Gruber, Reinhard +11 more
core +2 more sources
Effectiveness of Losartan-Loaded Hyaluronic Acid (HA) Micelles for the Reduction of Advanced Hepatic Fibrosis in C3H/HeN Mice Model. [PDF]
PLoS ONE, 2015 Advanced hepatic fibrosis therapy using drug-delivering nanoparticles is a relatively unexplored area. Angiotensin type 1 (AT1) receptor blockers such as losartan can be delivered to hepatic stellate cells (HSC), blocking their activation and thereby ...
Reju George Thomas +4 more
doaj +1 more source
Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]
, 2005 BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema +17 more
core +2 more sources
PROTECTIVE EFFECTS OF LOSARTAN AGAINST ETHANOL-INDUCED LIVER INJURY: A STUDY IN MALE WISTAR RATS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityObjectives: Chronic consumption of ethanol poses serious risks to liver health, resulting in oxidative stress and inflammation that can worsen hepatic dysfunction. This research explores the protective role of losartan, an angiotensin II receptor blocker
Mahdiyeh Hedayati -Moghadam +3 more
doaj +1 more source
Protecting the ischemic heart : pharmacological protection against myocardial ischemia in rats in vivo and in vitro [PDF]
, 2004 Today in Switzerland approximately 40% of all deaths are due to cardiovascular diseases. More than half of these are due to ischemic heart disease. Among the fatal consequences of ischemic heart disease are life-threatening arrhythmias and myocardial ...
Butz, Silvia
core +1 more source