Clinical and laboratory characterization of patients with localized scleroderma and response to UVA-1 phototherapy: In vivo and in vitro skin models. [PDF]
Photodermatol Photoimmunol Photomed, 2022 Abstract Background/Purpose Localized scleroderma (LS) is a rare disease leading to progressive hardening and induration of the skin and subcutaneous tissues. LS is responsive to UVA‐1 phototherapy, though its exact mechanism of action dermal fibrosis is yet to be fully elucidated.
Tognetti L +6 more
europepmc +5 more sources
UVA-1 phototherapy as adjuvant treatment for eosinophilic fasciitis: in vitro and in vivo functional characterization. [PDF]
Int J Dermatol, 2022 Abstract Introduction Eosinophilic fasciitis (EF) is a rare autoimmune disease causing progressive induration of dermal, hypodermal, and muscularis fascia. The exact pathogenesis is yet to be fully understood, and a validated therapy protocol still lacks. We here aimed to realize a clinical–functional characterization of these patients.
Tognetti L +8 more
europepmc +5 more sources
Study about evaluation of efficacy of methotrexate in localized scleroderma using ultrasonography. [PDF]
Skin Res Technol, 2023 Abstract Background The treatment and curative effect evaluation of localized scleroderma (LS) still perplexes many clinical workers. Purpose To investigate the efficiacy of methotrexate in the treatment of LS by the evaluation of ultrasonography. Methods A prospective study enrolled 10 patients treated with MTX for at least 6 months was conducted ...
Zhang F, Li J, Zhao Q, Liu H, Zhang F.
europepmc +2 more sources
Connective tissue nevus misdiagnosed as juvenile localized scleroderma. [PDF]
Pediatr Rheumatol Online J, 2023 BackgroundConnective tissue nevi (CTN) are congenital hamartomas caused by excessive proliferation of dermis components. In children, CTN can mimic juvenile localized scleroderma (JLS), an immune mediated skin disorder that requires aggressive ...
Tirelli F +7 more
europepmc +3 more sources
Role of imaging in morphea assessment: A review of the literature. [PDF]
Skin Res Technol, 2023 Abstract Background Localized scleroderma, known as morphea, is a connective tissue disorder characterized by inflammation and fibrosis of the skin and the soft tissue. There exist no universally accepted validated outcome measures in order to monitor the disease activity.
Khorasanizadeh F +2 more
europepmc +2 more sources
A phase 2b basket trial approach to treat multiple rare and fibrotic skin diseases. [PDF]
Front Med (Lausanne)Fibrotic skin diseases are rare, chronic, and often debilitating conditions characterized by excessive extracellular matrix deposition, leading to tissue scarring and functional impairment.
Volc S +8 more
europepmc +3 more sources
Intravenous immunoglobulin for the treatment of morphea in pediatric patients: A case series. [PDF]
JAAD Case RepMilakovic M +3 more
europepmc +2 more sources
КЛІНІЧНІ ОСОБЛИВОСТІ ЛОКАЛІЗОВАНОЇ СКЛЕРОДЕРМІЇ У ПАЦІЄНТІВ ІЗ ЛАЙМ-БОРЕЛІОЗОМ [PDF]
, 2022 SUMMARY. The aim – to establish the clinical features of localized scleroderma in patients with Lyme borreliosis. Material and Methods. There were 78 patients with localized scleroderma (LS) aged 18 to 74 years under supervision; in 2015–2021 they were ...
Шкільна, М. І. +1 more
core +5 more sources
Pediatric connective tissue diseases:Looking through the skin and beyond [PDF]
, 2022 In this thesis new disease biomarkers for chronic autoimmune diseases (‘connective tissue diseases’ (CTD)) such as childhood-onset Systemic Lupus Erythematosus (cSLE), Mixed Connective Tissue Disease (MCTD) and Localized Scleroderma (LS) are discussed ...
Schonenberg-Meinema, D.
core +4 more sources
Gluten-Free Diet in Children with Dermatologic Pathology
Педиатрическая фармакология, 2022 Background. Gluten-free diet (GFD) is a nutritional pattern that excludes such component of grain crops as gluten. This diet administration should be strictly regulated due to its influence on the growing child nutritional status and on the course of ...
Leonid A. Opryatin +2 more
doaj +1 more source