Results 21 to 30 of about 269 (119)

Quality of Life in Patients with Morphea: A Cross-Sectional Study and a Review of the Current Literature. [PDF]

Biomed Res Int, 2020
Introduction. Morphea (or localized scleroderma) is an inflammatory, immune‐mediated disease of unknown etiology. It is characterized by excessive collagen deposition that leads to hardening of the dermis, subcutaneous tissues, or both. Morphea is associated with cosmetic and functional impairment, which might affect the patients’ quality of life (QoL).
Szczęch J, Samotij D, Jaworecka K, Tobiasz A, Reich A.   +4 more
europepmc   +2 more sources

Juvenile Localized Scleroderma. Questions of Treatment

Вопросы современной педиатрии, 2020
Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS.
Rinat K. Raupov, Mikhail M. Kostik
doaj   +1 more source

Fractional erbium:yttrium aluminum garnet laser in the treatment of morphea mouse model

Journal of Cosmetic Dermatology, Volume 22, Issue 12, Page 3282-3290, December 2023., 2023
Abstract Objective To assess the efficiency and the mechanism of fractional erbium:yttrium aluminum garnet (Er:YAG) laser for the treatment of morphea in mouse model. Background Morphea is a rare autoimmune disease characterized by excessive collagen deposition in skin.
Qing Guo, Junjie Cen, Mingjie He, Danqi Huang, Zengqi Tang, Hui Xiong   +5 more
wiley   +1 more source

High-frequency ultrasound evaluation of morphea: Retrospective analytical study.

Skin Res Technol
Abstract Background To date, there are no accepted outcome measures to monitor morphea, and consensus on specific monitoring criteria for morphea remains elusive. A few studies have assessed the criterion validity of skin ultrasound in morphea. So, in this study, we approach ultrasound findings in morphea lesions.
Yazdanparast T, Mohseni A, Dehghan KS, Delavar S, Firooz A.   +4 more
europepmc   +2 more sources

Upcoming treatments for morphea

Immunity, Inflammation and Disease, Volume 9, Issue 4, Page 1101-1145, December 2021., 2021
Morphea is a rare connective tissue disease with variable clinical presentations, all of which are characterized by inflammatory fibrosis. No cure for morphea exists, but advances in our understanding of the mediators and cellular pathways underlying fibrosis have revealed potential therapeutic targets.
Dan Wenzel, Nazgol‐Sadat Haddadi, Khashayar Afshari, Jillian M. Richmond, Mehdi Rashighi   +4 more
wiley   +1 more source

Multi-centre national audit of juvenile localised scleroderma: describing current UK practice in disease assessment and management [PDF]

, 2018
OBJECTIVE: To describe current United Kingdom practice in assessment and management of patients with juvenile localised scleroderma (JLS) compared to Paediatric Rheumatology European Society (PRES) scleroderma working party recommendations.
Almeida, B, Bennett, J, Bhat, C, Bilkhu, A, Brennan, M, Dawson, P, Deepak, S, Eleftheriou, D, Harrison, K, Hawley, D, Heaf, E, Leone, V, Long, E, Lythgoe, H, Maltby, S, McErlane, F, Pain, CE, Rafiq, N, Ramanan, AV, Rangaraj, S, Riley, P, Varnier, G, Wilkinson, N   +22 more
core   +5 more sources

Prior elicitation of the efficacy and tolerability of Methotrexate and Mycophenolate Mofetil in Juvenile Localised Scleroderma [version 1; peer review: 2 approved] [PDF]

, 2021
Background: Evidence is lacking for safe and effective treatments for juvenile localised scleroderma (JLS). Methotrexate (MTX) is commonly used first line and mycophenolate mofetil (MMF) second line, despite a limited evidence base. A head to head trial
Anderson, Marina E, Anton, Jordi, Avcin, Tadej, Beresford, Michael W, Burnett, Thomas, Desai, Yasin, Eleftheriou, Despina, Felton, Jessie, Foeldvari, Ivan, Jacobe, Heidi, Jaki, Thomas, Laguda, Bisola, Leone, Valentina, Li, Suzanne, McErlane, Flora, Mozgunov, Pavel, Pain, Clare E, Ramanan, Athimalaipet V, Shaw, Lindsay, Torok, Kathryn S, Zulian, Francesco   +20 more
core  

Consensus-based recommendations for the management of juvenile localised scleroderma [PDF]

, 2019
In 2012, a European initiative called Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases ...
Anton, Jordi, Avcin, Tadej, Baildam, Eileen M, Boros, Christina, Chaitow, Jeffrey, Constantin, Tamàs, Culpo, Roberta, Foeldvari, Ivan, Kasapcopur, Ozgur, Knupp Feitosa de Oliveira, Sheila, Pilkington, Clarissa A, Russo, Ricardo, Saad Magalhães, Claudia, Sperotto, Francesca, Toplak, Natasa, van Royen, Annet, Vastert, Sebastiaan J, Wulffraat, Nico M, Zulian, Francesco   +18 more
core   +4 more sources

Clinical and therapeutic course in head variants of linear morphea in adults: a retrospective review. [PDF]

, 2022
Parry Romberg Syndrome (PRS) and en coup de sabre (ECDS) are head variants of linear morphea with functional and structural implications. This study describes the clinical course, autoimmune co-morbidities, complications, and treatment of adults with PRS/
Fan, Winnie, Gandelman, Jocelyn, Haemel, Anna, Jacobson, Rebecca, Obiakor, Bianca   +4 more
core   +1 more source

The role of skin trauma in the distribution of morphea lesions: A cross-sectional survey of the Morphea in Adults and Children cohort IV [PDF]

, 2014
Background: Skin trauma may play a role in the development of morphea lesions. The association between trauma and the distribution of cutaneous lesions has never been examined to our knowledge.
Andrew, R., Grabell, D., Hsieh, C., Jacobe, H., Kim, A., Martires, K., Vasquez, R.   +6 more
core   +2 more sources