Results 131 to 140 of about 138,753 (343)

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

LOSS OF HETEROZYGOSITY OF THE ESTROGEN-RECEPTOR GENE IN BREAST-CANCER [PDF]

, 1995
Barnes, DM, Bobrow, L, Greenman, JM, Hodgson, S, Iwase, H, Mathew, CG   +5 more
core   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Loss of heterozygosity and microsatellite instability as predictive markers among Iranian esophageal cancer patients [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis.
Mohammad Mahdi Forghanifard, Elham Emami Vahid, Ezzat Dadkhah, Mehran Gholamin, Samaneh Broumand Noghabi, Martha Ghahraman, Mehdi Farzadnia, Mohammad Reza Abbaszadegan   +7 more
doaj  

Molecular genetic analysis of flow-sorted ovarian tumour cells: improved detection of loss of heterozygosity [PDF]

, 1994
ECA Abeln, Willem E. Corver, Nel J. Kuipers‐Dijkshoorn, Gert Jan Fleuren, Cees J. Cornelisse   +4 more
openalex   +1 more source

Genomic signatures of heterokaryosis in the oomycete pathogen Bremia lactucae. [PDF]

, 2019
Lettuce downy mildew caused by Bremia lactucae is the most important disease of lettuce globally. This oomycete is highly variable and rapidly overcomes resistance genes and fungicides.
Bertier, Lien D, Cavanaugh, Keri, Fletcher, Kyle, Gil, Juliana, Kenefick, Aubrey, Michelmore, Richard, Reyes-Chin-Wo, Sebastian, Tsuchida, Cayla, Wong, Joan, Wood, Kelsey J, Zhang, Lin   +10 more
core  

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Loss of Heterozygosity on the Short Arm of Chromosome 9 without p16 Gene Mutation in Gastric Carcinomas [PDF]

, 1995
Ken Sakata, G Tamura, Chihaya Maesawa, Yasushi Suzuki, Masanori Terashima, Kunio Satoh, Yoshiki Eda, Akihiko Suzuki, Saburō Sekiyama, Ryoichi Satodate   +9 more
openalex   +1 more source

Drift and evolutionary forces: scrutinizing the Newtonian analogy [PDF]

, 2016
This article analyzes the view of evolutionary theory as a theory of forces. The analogy with Newtonian mechanics has been challenged due to the alleged mismatch between drift and the other evolutionary forces. Since genetic drift has
Luque, Víctor J.
core