Results 71 to 80 of about 152,101 (230)

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis.

Blood, 2012
Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and myelodysplastic syndromes, pointing toward the essential role of this region in disease phenotype and clonal evolution.
A. Jerez, Y. Sugimoto, H. Makishima, A. Verma, A. Jankowska, B. Przychodzen, V. Visconte, R. Tiu, C. O'keefe, A. Mohamedali, A. Kulasekararaj, A. Pellagatti, K. McGraw, H. Muramatsu, A. Moliterno, M. Sekeres, M. McDevitt, S. Kojima, A. List, J. Boultwood, G. Mufti, J. Maciejewski   +21 more
semanticscholar   +1 more source

Genetic Requirements for Intra-Chromosomal Deletions [PDF]

, 2020
Chromosomal deletions are one of the most dangerous types of DNA damage and often arise as a result of inappropriately repaired DNA double strand breaks (DSB).
McPherson, Matthew
core  

Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation.

PLoS Genetics, 2013
Serrated adenomas form a distinct subtype of colorectal pre-malignant lesions that may progress to malignancy along a different molecular pathway than the conventional adenoma-carcinoma pathway.
Andrew D Beggs, Angela Jones, Neil Shepherd, Abed Arnaout, Caroline Finlayson, A Muti Abulafi, Dion G Morton, Glenn M Matthews, Shirley V Hodgson, Ian P M Tomlinson   +9 more
doaj   +1 more source

Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma

Cancer Medicine, 2020
Background Epigenetic inactivation of O6‐methylguanine‐methyltransferase (MGMT) gene by methylation of its promoter is predictive of Temozolomid (TMZ) response in glioblastoma (GBM).
Sophie Richard, Gaëlle Tachon, Serge Milin, Michel Wager, Lucie Karayan‐Tapon   +4 more
doaj   +1 more source

Potential inbreeding in a small population of a mass flowering species, Xanthorrhoea johnsonii (Xanthorrhoaceae): is your mother my father? [PDF]

, 2012
Xanthorrhoea johnsonii is a long lived slow growing perennial understorey species, that produces a large quantity of passively dispersed seed every 3-5 years. Reproductive maturity is not reached until 20-30 years of age.
King, Rachel, Zalucki, Jacinta M.
core   +1 more source

Research of loss of heterozygaity on chromosome 3p in non-small cell lung cancer

Chinese Journal of Lung Cancer, 2008
Background and objective It has been proven that allelic loss of chromosome region 3p occurs early and frequently in non-small-cell lung cancer, and numerous tumor suppressor genes at this locus may be targets of inactivation. The aim of this study is to
Xinyu MEI, Yujie SUN, Meiqing XU, Dongchun MA, Dazhong WEI, Jieyong TIAN, Zixue REN   +6 more
doaj  

Phenomenon of loss of heterozygosity in tumour tissue of breast cancer: association with expression of monoresistance genes

Бюллетень сибирской медицины, 2018
Purpose of work. To perform a genome-wide association study of loss of heterozygosity (LOH) with monoresistance genes expression during neoadjuvant chemotherapy (NAC) in breast cancer.Materials and methods.
M. M. Tsyganov, I. V. Deryusheva, E. Yu. Garbukov, M. K. Ibragimova, P. V. Kazantseva, V. A. Bychkov, E. M. Slonimskaya, N. V. Litviakov   +7 more
doaj   +1 more source

Analysis of loss of heterozygosity of the tumor suppressor genes p53 and BRCA1 in ovarial carcinomas [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: Among the genes involved in ovarian carcinogenesis, there has been increased interest in tumor-suppressor genes p53 and BRCA1. Both of the genes make control of cell cycle, DNA repair and apoptosis.
Luković Ljiljana, Popović Branka, Atanacković Jasmina, Novaković Ivana, Perović Milica, Petrović Bojana, Petković Spasoje   +6 more
doaj   +1 more source

Characterization of mutations and loss of heterozygosity of p53 and K-\u3ci\u3eras\u3c/i\u3e2 in pancreatic cancer cell lines by immobilized polymerase chain reaction [PDF]

, 2003
Background The identification of known mutations in a cell population is important for clinical applications and basic cancer research. In this work an immobilized form of the polymerase chain reaction, referred to as polony technology, was used to ...
Butz, James, Edwards, Jeremy, Wickstrom, Eric   +2 more
core   +1 more source

Laboratory colonisation and genetic bottlenecks in the tsetse fly Glossina pallidipes [PDF]

, 2014
Background The IAEA colony is the only one available for mass rearing of Glossina pallidipes, a vector of human and animal African trypanosomiasis in eastern Africa. This colony is the source for Sterile Insect Technique (SIT) programs in East Africa.
Ciosi, Marc, Masiga, Daniel K., Turner, Charles M.R.   +2 more
core   +3 more sources