Results 81 to 90 of about 152,101 (230)

Loss of heterozygosity in acute leukemia: evidence of frequent submicroscopic deletions

Haematologica, 2007
Although chromosomal abnormalities are detected by conventional cytogenetic analysis (CCA) in 40–60% of patients with acute myeloid leukemia (AML), cryptic chromosomal deletions may only be detected by molecular analysis. To determine their frequency, we
Cecilia Agueli, Rosaria Basiricò, Francesco Fabbiano, Valentina Rizzo, Lucia Cascio, Giuseppe Cammarata, Anna Marfia, Maria La Rosa, Salvo Mirto, Alessandra Santoro   +9 more
doaj   +1 more source

High Genetic Diversity and Low Differentiation of Michelia coriacea (Magnoliaceae), a Critically Endangered Endemic in Southeast Yunnan, China [PDF]

, 2012
Michelia coriacea, a critically endangered tree, has a restricted and fragmented distribution in Southeast Yunnan Province, China. The genetic diversity, genetic structure and gene flow in the three extant populations of this species were detected by 10 ...
Archak, Bauert, Belaj, Benor, Budak, Chen, Chiang, Cicuzza, Dan, Dong, Doyle, Evanno, Excoffier, Frankel, Ge, Godt, Hamrick, Ikegami, Kikuchi, Kingston, Lande, Liao, Liu, Loveless, Lu, Luan, Ma, Maguire, Nei, Neigel, Nybom, Peakall, Powell, Pritchard, Qiao, Raymond, Richard Milne, Rossetto, Schaal, Shui, Sun, Sun, Wang, Weibang Sun, Whitlock, Wu, Xiangying Wen, Xingfeng Zhao, Yao, Yeh, Yongpeng Ma, Zawko, Zhang, Zhao, Zhou   +54 more
core   +3 more sources

Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV

Bioinform., 2011
MOTIVATION The ability to detect copy-number variation (CNV) and loss of heterozygosity (LOH) from exome sequencing data extends the utility of this powerful approach that has mainly been used for point or small insertion/deletion detection. RESULTS We
J. Sathirapongsasuti, Hane Lee, B. Horst, G. Brunner, A. Cochran, S. Binder, John Quackenbush, S. Nelson   +7 more
semanticscholar   +1 more source

Liver: Intrahepatic cholangiocarcinoma [PDF]

, 2009
Review on Liver: Intrahepatic cholangiocarcinoma, with data on clinics, and the genes ...
Aishima, S, Enjoji, M
core   +1 more source

Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicans

mBio, 2011
Genetic diversity is often generated during adaptation to stress, and in eukaryotes some of this diversity is thought to arise via recombination and reassortment of alleles during meiosis.
A. Forche, D. Abbey, T. Pisithkul, M. A. Weinzierl, T. Ringstrom, D. Bruck, K. Petersen, J. Berman   +7 more
semanticscholar   +1 more source

No evidence for a recent genetic bottleneck in the endangered Sheko cattle breed (African Bos taurus) revealed by microsatellite analysis [PDF]

, 2009
Sheko is African taurine cattle, valued for its milk yield, adaptation to humid tsetse infested environment and trypanotolerance. We used 30 microsatellite markers in analyzing 30 DNA samples. We found high genetic diversity and no genetic bottlenecks in
Hailu Dadi, Hirofumi Hanada, Joram Mwacharo, Koh Nomura, Markos Tibbo, Takashi Amano, Yukimizu Takahashi   +6 more
core   +1 more source

Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.

Journal of Clinical Oncology, 2011
PURPOSE Colorectal cancer (CRC) develops as a result of a series of accumulated genomic changes that produce oncogene activation and tumor suppressor gene loss.
M. Bertagnolli, M. Redston, C. Compton, D. Niedzwiecki, R. Mayer, R. Goldberg, T. Colacchio, L. Saltz, R. Warren   +8 more
semanticscholar   +1 more source

Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas. [PDF]

, 2016
Malignant pleural mesothelioma (MPM), a rare malignancy with a poor prognosis, is mainly caused by exposure to asbestos or other organic fibers, but the underlying genetic mechanism is not fully understood.
Fang, Li Tai, Jablons, David M, Jen, Kuang-Yu, Jones, Kirk, Kang, Hio Chung, Kim, Hong Kwan, Kim, Il-Jin, Kim, James Wansoo, Lee, Sharon, Mendez, Pedro, Woodard, Gavitt, Yoon, Jun-Hee   +11 more
core   +3 more sources

Testing the theory of immune selection in cancers that break the rules of transplantation [PDF]

, 2009
Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.
A Garcia-Lora, A Scheffold, AF Setiadi, AM Pearse, Ariberto Fassati, B Comin-Anduix, B Kavanagh, B Muller-Hilke, C Murgia, CA Rebbeck, CC Chang, CL Yauk, CM Gonzalez, CM Koebel, CY Lin, D Cohen, D Cohen, D Cohen, D Cohen, E Ambrosino, E Klein, E Mozos, ED Carosella, ED Carosella, EK Geissler, FR Depontieu, G Willimsky, GD Snell, GP Dunn, GP Dunn, GP Dunn, H Ikeda, H McCallum, H Wajant, HV Siddle, HV Siddle, I Kryczek, J Galon, J Hori, J Perez, J Zhou, K Kretschmer, K Masuda, K Milne, KJ Malmberg, KL Wright, L Tian, L Vago, L Yip, M Bleakley, M Campoli, M Gerloni, M Mammolenti, M Mehling, M Novinski, M Pierobon, M Shackleton, M Thornley, MA Cheever, MN Scherer, N Mitchison, N Schwinn, N. Avrion Mitchison, NA Mitchison, NM Moutsopoulos, P Jimenez, PC Chou, R Mendez, R Mendez, R Uppaluri, S Lob, S Verheyden, SM Kang, SR Choudhury, T Akagi, T Cabrera, T Isoda, T Marchal, T Rodriguez, TJ Yang, TJ Yang, W Reith, YC Chang, YW Hsiao, YW Hsiao   +84 more
core   +2 more sources

Continental-scale patterns of pathogen prevalence: a case study on the corncrake [PDF]

, 2014
Pathogen infections can represent a substantial threat to wild populations, especially those already limited in size. To determine how much variation in the pathogens observed among fragmented populations is caused by ecological factors, one needs to ...
Barton K., Bates D., Beaumont M. A., Burnham K. P., Coltman D., Goudet J., Green R. E., Green R. E., Schäffer N., Valkiūnas G.   +9 more
core   +2 more sources