Results 51 to 60 of about 317,672 (284)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Thrasymachus, the Sight-lover

Revista de Filosofia Antiga
The aim of this paper is to explain why Thrasymachus, upon first appearing in Republic I, prohibits Socrates from defining justice as what is good. I argue that Thrasymachus views such definitions as equivocal, since he conceives of the good as relative:
Clifford Roberts
doaj   +1 more source

VALUE OF LIFE PADA MAHASISWA PENIKMAT DUNIA MALAM [PDF]

, 2010
Modernism has made modern value entering societies all over the world. This modern values brought a lifestyle Hedonis society considered as ‘modern’ and became reference of society’s life.
Rosidah, Okta Viatur
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Regional initiatives for malaria elimination: Building and maintaining partnerships.

PLoS Medicine, 2017
Andrew Lover and colleagues discuss regional malaria initiatives, the strengths and challenges.
Andrew A Lover, Kelly E Harvard, Alistair E Lindawson, Cara Smith Gueye, Rima Shretta, Roly Gosling, Richard Feachem   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

AŞKIN (SEVGİNİN) GÜCÜ

Felsefe Dünyası, 2005
Ömer ÖZDEN, AŞKIN (SEVGİNİN) GÜCÜ, FELSEFE DÜNYASI DERGİSİ, SAYI:42 ...
Ömer Özden
doaj  

Gender and Power Relations in David Henry Hwang’s M. Butterfly: The Challenge to the Binary Opposition Between the East and the West [PDF]

, 2012
David Henry Hwang’s M Butterfly tells about a French diplomat, Gallimard, who has a 20 year relationship with his Chinese lover, Song, who turns out to be a male spy.
Nurulhady, Eta Farmacelia
core  

Beyond the story of storytelling: the Narrator as Lover in Ariosto’s Orlando Furioso [PDF]

, 2015
The article builds on the well-established tradition of studies devoted to metanarration and metafiction in Ariosto’s Orlando furioso to focus on the Narrator as a key self-reflexive device, while questioning the common identification of the Narrator as ...
Pich, F
core   +1 more source