Results 161 to 170 of about 358 (231)

Ubiquitin C‐Terminal Hydrolase L1 (UCHL1), Beyond Hydrolysis

BioEssays, EarlyView.
UCHL1 is a neuron‐enriched component of the ubiquitin‐proteasome system. This review debates the biological relevance of its biochemical roles: limited DUB activity, potential ligase function, and mono‐ubiquitin stabilization. We emphasize the need to clarify the mechanisms and identify natural substrates for each function to understand their role in ...
Anwar Bdarneh, Inbal Maniv, Michael H. Glickman   +2 more
wiley   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Restoration of human tooth enamel

BMEMat, EarlyView.
Human tooth enamel has remarkable properties but lacks self‐repair ability. Existing restorative materials cannot fully replicate enamel's microstructure and function, resulting in low restorative efficiency. This review summarizes the formation process and characteristics of enamel, and current restorative materials and future research directions are ...
Hanlin Liu, Bo Li, Mingrui Gao, Yangbei Li, Xiuyi Yang, Fengshi Li, Zhi Cai, Yi Liu, Shaojia Liu, Hewei Zhao, Lin Guo   +10 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

BMEMat, EarlyView.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li, Huaijuan Zhou, Di Shi, Zdeněk Sofer, Jinhua Li   +4 more
wiley   +1 more source

Digital Product Passports as Information Providers for Consumers—The Case of Digital Battery Passports

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainable consumption is crucial to transitioning toward a more sustainable society. Various tools, including information provision tools such as ecolabels, aim to promote sustainable consumption but are often criticized for failing to adequately inform consumers. This study examines digital product passports (DPPs), an emerging policy tool,
Martin Popowicz, Antonia Pohlmann, Josef‐Peter Schöggl, Rupert J. Baumgartner   +3 more
wiley   +1 more source

Single‐Ion Conductive Bacterial Cellulose Membrane Towards High Performance Lithium‐Oxygen Batteries

Battery Energy, EarlyView.
Bacterial cellulose (BC) is a natural polymer with ultrafine nanofibrous network. BC membrane has excellent affinity to organic electrolyte, high ionic conductivity and inherent ion selectivity, which can transfer lithium ions and suppress the shuttling of anions across the membrane, available for iodide‐assisted lithium‐oxygen batteries (LOBs ...
Aqiang Wu, Mingxing Wang, Yaming Pang, Xinyu Li, Xiangqun Zhuge, Zhihong Luo, Guogang Ren, Kun Luo, Yurong Ren, Dan Liu, Weiwei Lei, Jianwei Lu   +11 more
wiley   +1 more source