Results 281 to 290 of about 91,338 (326)

Low-affinity nerve growth factor receptors (p75 LNGFR ) in human prostate tissue: stromal localisation

Urological Research, 1998
Beta-nerve growth factor (beta-NGF) acts on high- and low-affinity receptors to effect sympathetic innervation. It is produced in the human prostate. This study aimed to demonstrate the presence of beta-NGF receptors and the distribution of p75LNGFR receptor protein in the human prostate.
A, Paul, F, Habib
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Low‐Affinity Nerve Growth Factor Receptor p75NTR Immunoreactivity in the Myocardium with Sympathetic Hyperinnervation

Journal of Cardiovascular Electrophysiology, 2004
Introduction: We previously demonstrated the relationship between sympathetic nerve density in myocardium and the occurrences of ventricular arrhythmia. Nerve growth factor (NGF) regulates myocardial sympathetic innervation. However, it is unclear whether the NGF high‐affinity receptor tyrosine kinase A (TrkA) and the NGF low‐affinity receptor p75NTR ...
Shengmei Zhou, Ji‐Min Cao, Moshe Swissa, Ignacio González-Gómez, Che-Ming Chang, K. R. Chien, Yasushi Miyauchi, Katherine J. Fu, Johnny Yi, Kamlesh Asotra, Hrayr S. Karagueuzian, Michael C. Fishbein, PENG‐SHENG CHEN, Lan S. Chen   +13 more
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Cell type-specific negative regulatory element in low-affinity nerve growth factor receptor gene

Molecular Brain Research, 1993
Developmental changes in the expression pattern of the low-affinity nerve growth factor receptor (LNGFR) gene suggest a complex mechanism of gene regulation. We demonstrate the presence of a negative regulatory element (NRE) localized to a 40 base pair (bp) segment, -1731 to -1690 bp upstream from the translation start site in the LNGFR gene.
Neuman, T., Metsis, M., Persson, H., Gruss, P.   +3 more
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Regulation of nerve growth factor and its low-affinity receptor (p75NTR) during myogenic differentiation

Journal of Cellular Physiology, 1998
In our preceding report, we have shown that nerve growth factor (NGF) and its low-affinity receptor (p75NTR) are expressed in C2C12 myoblasts and downregulated during myogenic differentiation. Furthermore, NGF affects myogenic differentiation and cell growth via p75NTR and downregulation of p75NTR is essential for myogenic differentiation (Seidl et al.,
Erck, Christian, Meisinger, Chris, Grothe, Claudia, Seidl, Klaus   +3 more
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Immunohistochemical Analysis of Low-Affinity Nerve Growth Factor Receptor in the Human Urinary Bladder

Urologia Internationalis, 2006
<i>Introduction:</i> Interest in the regulation of nerve growth factor (NGF) production in the urinary tract derives from its probable involvement in obstructive, inflammatory and developmental disorders. Our aim was to investigate the presence of low-affinity nerve growth factor receptor (LNGFR) in the vesical urothelium of patients with ...
Bilal, Eryildirim, Fatih, Tarhan, Aylin Ege, Gül, Erkan, Erbay, Uğur, Kuyumcuoğlu   +4 more
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Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75

Neuroscience Letters, 1998
Endogenous nerve growth factor (NGF) has been shown to be an important mediator of inflammatory pain and exogenous application of recombinant human NGF (rhNGF) produces pain and hyperalgesia in animals and humans. Since NGF can act through two receptors types, the high affinity tyrosine kinase A (trkA) receptor and the low affinity p75 receptor, we ...
I, Bergmann, R, Reiter, K V, Toyka, M, Koltzenburg   +3 more
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Role of low‐affinity p75 receptor in nerve growth factor‐inducible growth arrest of PC12 cells

Journal of Neuroscience Research, 2002
AbstractMutant PC12 cell clones (PC84 cells) were obtained by transfection with nerve growth factor (NGF) cDNA. These cells secreted active NGF, extended short processes, and proliferated faster than the parental PC12 cells. These features are of great interest because the parental PC12 cells cease proliferation and extend long processes when ...
Hisanori, Ito, Hiroshi, Nomoto, Shoei, Furukawa   +2 more
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Role of the low‐affinity nerve growth factor receptor and the high‐affinity trk nerve growth factor receptor in human prostate carcinogenesis

Radiation Oncology Investigations, 1995
AbstractNerve growth factor (NGF) interacts with a low‐affinity NGF receptor (LNGFR) and a high‐affinity Trk receptor in the paracrine regulation of human prostate growth. Both the LNGFR and the Trk receptor localize to the epithelia of the normal prostate. During malignant progression of the prostate, expression of the LNGFR is progressively lost from
Daniel Djakiew, Robert Delsite, Rakhi Dalai, Beth Pflug   +3 more
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Diagnostic utility of low-affinity nerve growth factor receptor (P 75) immunostaining in atypical fibroxanthoma

Journal of Cutaneous Pathology, 2011
Atypical fibroxanthoma (AFX) is a locally destructive, dermal-based, fibrohistiocytic, mesenchymal tumor. Immunohistochemistry helps to differentiate AFX from squamous cell carcinoma and spindle cell melanoma. Immunomarkers against p75 yield positive stains in spindled cell melanomas and negative stains in AFX, suggesting that these may be useful in ...
Christian, Bull, Marjan, Mirzabeigi, William, Laskin, Meghan, Dubina, Tom, Traczyc, Joan, Guitart, Pedram, Gerami   +6 more
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Loss of low-affinity nerve growth factor receptor during malignant transformation of the human prostate

The Prostate, 1997
The low-affinity nerve growth factor receptor (LNGFR) exhibits an inverse association of epithelial expression with the degree of differentiation of prostate adenocarcinoma tissue. However, the stage at which loss of LNGFR expression is first manifested in the malignant prostate has not been determined.In order to characterize loss of LNGFR expression ...
M, Perez, T, Regan, B, Pflug, J, Lynch, D, Djakiew   +4 more
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