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The low‐affinity nerve growth factor receptor p75NGFR mediates death of PC12 cells after nerve growth factor withdrawal [PDF]
We have investigated the role of the low-affinity nerve growth factor (NGF) receptor p75NGFR in determining the death of neuronally differentiated PC12 cells after withdrawal of NGF. A range of high and low p75NGFR-expressing cells were obtained by a combination of fluorescence activated cell sorting (FACS) and stable transfection with a p75NGFR ...
Graham L. Barrett, A. Georgiou
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Glia, 1997
Schwann cells in the distal stump of injured peripheral nerves synthesize the low affinity nerve growth factor receptor (p75). In this study we used short-term (1 week) and long-term (1-12 months) transected distal sciatic nerves of rats to determine the variations of p75 expression by using immunocytochemistry and in situ hybridization.
S. You+3 more
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Schwann cells in the distal stump of injured peripheral nerves synthesize the low affinity nerve growth factor receptor (p75). In this study we used short-term (1 week) and long-term (1-12 months) transected distal sciatic nerves of rats to determine the variations of p75 expression by using immunocytochemistry and in situ hybridization.
S. You+3 more
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The Prostate, 1997
The low-affinity nerve growth factor receptor (LNGFR) exhibits an inverse association of epithelial expression with the degree of differentiation of prostate adenocarcinoma tissue. However, the stage at which loss of LNGFR expression is first manifested in the malignant prostate has not been determined.In order to characterize loss of LNGFR expression ...
Manuel Perez+4 more
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The low-affinity nerve growth factor receptor (LNGFR) exhibits an inverse association of epithelial expression with the degree of differentiation of prostate adenocarcinoma tissue. However, the stage at which loss of LNGFR expression is first manifested in the malignant prostate has not been determined.In order to characterize loss of LNGFR expression ...
Manuel Perez+4 more
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Journal of Neuroscience Research, 1999
Neuroanatomical studies of schizophrenia suggest that progressive neuropathological changes (such as neuronal atrophy and/or cell death) occur over the lifetime course of the disease. Early intervention with atypical neuroleptics has been shown to prevent progression of at least some symptoms, although the mechanisms by which neuroleptics may do this ...
Xin‐Min Li+7 more
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Neuroanatomical studies of schizophrenia suggest that progressive neuropathological changes (such as neuronal atrophy and/or cell death) occur over the lifetime course of the disease. Early intervention with atypical neuroleptics has been shown to prevent progression of at least some symptoms, although the mechanisms by which neuroleptics may do this ...
Xin‐Min Li+7 more
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Urologia Internationalis, 2006
<i>Introduction:</i> Interest in the regulation of nerve growth factor (NGF) production in the urinary tract derives from its probable involvement in obstructive, inflammatory and developmental disorders. Our aim was to investigate the presence of low-affinity nerve growth factor receptor (LNGFR) in the vesical urothelium of patients with ...
B. Eryıldırım+4 more
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<i>Introduction:</i> Interest in the regulation of nerve growth factor (NGF) production in the urinary tract derives from its probable involvement in obstructive, inflammatory and developmental disorders. Our aim was to investigate the presence of low-affinity nerve growth factor receptor (LNGFR) in the vesical urothelium of patients with ...
B. Eryıldırım+4 more
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Journal of Comparative Neurology, 1991
AbstractWe studied the temporal and spatial localization of the low‐affinity nerve growth factor receptor (LNGF‐R) during the early postnatal period in rat brain in order to understand better the relationship between nerve growth factor (NGF)‐like responsiveness and the development of specific central neuronal populations.
S. Koh, G. Higgins
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AbstractWe studied the temporal and spatial localization of the low‐affinity nerve growth factor receptor (LNGF‐R) during the early postnatal period in rat brain in order to understand better the relationship between nerve growth factor (NGF)‐like responsiveness and the development of specific central neuronal populations.
S. Koh, G. Higgins
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Journal of Cutaneous Pathology, 2010
Background: Perineural invasion (PNI) is a well‐recognized route of tumor extension in cutaneous neoplasms. Despite an established association with increased local recurrences and metastases, the mechanisms responsible for PNI have yet to be elucidated. We hypothesize that P75 NGFR, a nerve growth factor receptor, may be implicated in the pathogenesis
Maren M. Chan, S. Tahan
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Background: Perineural invasion (PNI) is a well‐recognized route of tumor extension in cutaneous neoplasms. Despite an established association with increased local recurrences and metastases, the mechanisms responsible for PNI have yet to be elucidated. We hypothesize that P75 NGFR, a nerve growth factor receptor, may be implicated in the pathogenesis
Maren M. Chan, S. Tahan
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Modulation of low‐affinity nerve growth factor receptor in injured adult rat spinal cord motoneurons
Journal of Comparative Neurology, 1993AbstractSpinal and brainstem motoneurons of the adult rat reexpress low‐affinity nerve growth factor receptor (LNGFR) and its mRNA after axotomy. We have previously reported the time courses of this reexpression after cut (no regeneration) or crush (followed by regeneration) of the sciatic nerve. We have shown that the length of the different phases of
M. Rende, C. Provenzano, P. Tonali
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Localization of trkB and low-affinity nerve growth factor receptor mRNA in the developing rat retina
Neuroscience Letters, 1995The localization of trkB and low-affinity nerve growth factor receptor (LNGFR) mRNAs in the developing rat retina was examined by in situ hybridization. TrkB mRNA was expressed in the ganglion cell layer (GCL), in the inner border of the neuroblastic layer (NBL), and the inner border of the inner nuclear layer (INL). LNGFR mRNA was expressed in the GCL,
T. Koide+6 more
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Somatosensory & Motor Research, 1993
Disruption of the 75-kD low-affinity nerve growth factor (NGF) receptor (p75) has been shown to result in sensory and sympathetic nervous system deficits (Lee et al., 1992a,b).
G. Schatteman+3 more
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Disruption of the 75-kD low-affinity nerve growth factor (NGF) receptor (p75) has been shown to result in sensory and sympathetic nervous system deficits (Lee et al., 1992a,b).
G. Schatteman+3 more
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