Results 21 to 30 of about 91,338 (326)
FEBS Open Bio, 2022 Current treatment options for diabetic neuralgia are limited and unsatisfactory. Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain ...
Xingchen Dong +10 more
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Biochemistry and Biophysics Reports, 2021 The low-affinity nerve growth factor receptor p75 is a stratified epithelial stem/progenitor marker of human epithelia. We found OM-1, a human squamous cell carcinoma (SCC) cell line, showed distinct cells with p75 cluster, especially located at the ...
Ryo Uetsuki +11 more
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Adenocarcinomas of the Lung and Neurotrophin System: A Review
Biomedicines, 2022 Neurotrophins (NTs) represent a group of growth factors with pleiotropic activities at the central nervous system level. The prototype of these molecules is represented by the nerve growth factor (NGF), but other factors with similar functions have been ...
Alberto Ricci +5 more
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Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor. [PDF]
Proceedings of the National Academy of Sciences, 1991 Nerve growth factor (NGF) exerts a variety of actions during embryonic development. At the early stages of inner ear development, NGF stimulates cell proliferation, an effect mediated through low-affinity receptors. We have studied the possibility that the glycosyl-phosphatidylinositol/inositol phosphoglycan (glycosyl-PtdIns/IPG) system is involved in ...
Juan Represa +7 more
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Do Neurotrophins Connect Neurological Disorders and Heart Diseases?
Biomolecules, 2021 Neurotrophins (NTs) are one of the most characterized neurotrophic factor family members and consist of four members in mammals. Growing evidence suggests that there is a complex inter- and bi-directional relationship between central nervous system (CNS)
Masashi Fujitani +2 more
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Journal of Biological Chemistry, 1994 The binding domain of the low affinity nerve growth factor receptor (p75NGFR) is built from four "cysteine repeats," with almost identical patterns of half-cystine residues. To study the pattern of disulfide bridging within each cysteine repeat, we have mutated pairs of cysteine residues, primarily in the fourth repeat, and have tested the relative ...
Anne Norris Baldwin, Eric M. Shooter
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Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity. [PDF]
Proceedings of the National Academy of Sciences, 1994 The low-affinity nerve growth factor receptor (NGFR) p75NGFR induces apoptosis in the absence of nerve growth factor (NGF) binding but enhances neural survival when bound by NGF. Basal forebrain cholinergic neurons express the highest levels of p75NGFR in the adult human brain and are preferentially involved in Alzheimer disease, raising the question ...
Shahrooz Rabizadeh +3 more
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Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer [PDF]
, 2016 The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate ...
Biordi, Leda +9 more
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NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. [PDF]
PLoS ONE, 2009 BACKGROUND:Overall expression of neurotrophins in the respiratory tract is upregulated in infants infected by the respiratory syncytial virus (RSV), but it is unclear where (structural vs. inflammatory cells, upper vs.
Sreekumar Othumpangat +3 more
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Molecular Therapy: Oncolytics, 2022 Chimeric antigen receptor (CAR) T cell therapy has demonstrated unprecedented success with high remission rates for heavily pretreated patients with hematological malignancies.
A. Bister +11 more
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