Results 21 to 30 of about 358 (231)

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Biomedicines, 2022
Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic ...
Thanasis Rogdakis, Despoina Charou, Alessia Latorrata, Eleni Papadimitriou, Alexandros Tsengenes, Christina Athanasiou, Marianna Papadopoulou, Constantina Chalikiopoulou, Theodora Katsila, Isbaal Ramos, Kyriakos C. Prousis, Rebecca C. Wade, Kyriaki Sidiropoulou, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos   +15 more
doaj   +1 more source

Analgesic effects of nerve growth factor‐directed monoclonal antibody on diabetic neuralgia in an animal model

FEBS Open Bio, 2022
Current treatment options for diabetic neuralgia are limited and unsatisfactory. Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain ...
Xingchen Dong, Huanhuan Li, Min Pei, Jie Tan, Ganjun Chen, Santai Li, Zuobin Xie, Qi Wang, Guifeng Wang, Yi‐Li Chen, Chunhe Wang   +10 more
doaj   +1 more source

Adenocarcinomas of the Lung and Neurotrophin System: A Review

Biomedicines, 2022
Neurotrophins (NTs) represent a group of growth factors with pleiotropic activities at the central nervous system level. The prototype of these molecules is represented by the nerve growth factor (NGF), but other factors with similar functions have been ...
Alberto Ricci, Claudia Salvucci, Silvia Castelli, Antonella Carraturo, Claudia de Vitis, Michela D’Ascanio   +5 more
doaj   +1 more source

Do Neurotrophins Connect Neurological Disorders and Heart Diseases?

Biomolecules, 2021
Neurotrophins (NTs) are one of the most characterized neurotrophic factor family members and consist of four members in mammals. Growing evidence suggests that there is a complex inter- and bi-directional relationship between central nervous system (CNS)
Masashi Fujitani, Yoshinori Otani, Hisao Miyajima   +2 more
doaj   +1 more source

NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. [PDF]

PLoS ONE, 2009
BACKGROUND:Overall expression of neurotrophins in the respiratory tract is upregulated in infants infected by the respiratory syncytial virus (RSV), but it is unclear where (structural vs. inflammatory cells, upper vs.
Sreekumar Othumpangat, Laura F Gibson, Lennie Samsell, Giovanni Piedimonte   +3 more
doaj   +1 more source

Brain‐Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Brain‐derived neurotrophic factor (BDNF) is expressed in neuronal and nonneuronal cells and may affect vascular functions via its receptor, tropomyosin‐related kinase B (TrkB).
Sarah Zierold, Katja Buschmann, Sogol Gachkar, Magdalena L. Bochenek, David Velmeden, Lukas Hobohm, Christian‐Friedrich Vahl, Katrin Schäfer   +7 more
doaj   +1 more source

Expression of NGF, Trka and p75 in human cartilage

European Journal of Histochemistry, 2009
Nerve growth factor (NGF) exerts its action through two types of receptor: high-affinity tyrosine kinase A receptor (trkA) and low-affinity p75 receptor.
A Gigante, C Bevilacqua, A Pagnotta, S Manzotti, A Toesca, F Greco   +5 more
doaj   +1 more source

Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis

Acta Dermato-Venereologica, 2019
Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in ...
Weilong Zhong, Xia Wu, Wei Zhang, Jie Zhang, Xiaofan Chen, Shihong Chen, Haiyan Huang, Yong Yang, Bo Yu, Xia Dou   +9 more
doaj   +1 more source

Neurotrophins and Neuropathic Pain: Role in Pathobiology

Molecules, 2015
Neurotrophins (NTs) belong to a family of trophic factors that regulate the survival, growth and programmed cell death of neurons. In mammals, there are four structurally and functionally related NT proteins, viz. nerve growth factor (NGF), brain-derived
Nemat Khan, Maree T. Smith
doaj   +1 more source

Polysialylation of NCAM characterizes the proliferation period of contractile elements during postnatal development of the epididymis. [PDF]

PLoS ONE, 2015
Polysialic acid (polySia) attached to the neural cell adhesion molecule (NCAM) regulates inter alia the proliferation and differentiation via the interactions with neurotrophins.
Peter Simon, Caroline Feuerstacke, Miriam Kaese, Farhan Saboor, Ralf Middendorff, Sebastian P Galuska   +5 more
doaj   +1 more source