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Human hematopoietic stem cells remain one of the most promising target cells for gene therapeutic approaches to treat malignant and nonmalignant diseases.
Boris Fehse+9 more
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Deficits or excesses of thyroid hormones during critical periods of mammalian cerebellar development can lead to profound biochemical and morphological abnormalities in this system. The goal of this study was to investigate the effects of perinatal hypo- and hyperthyroidism on the ontogeny of nerve growth factor (NGF) and its low-affinity receptor ...
Bonald C. Figueiredo+4 more
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The interaction of neurotrophins and their tyrosine kinase receptors (trks) is essential for differentiation and survival of brain cells. In Alzheimer's disease (AD), the number of neurotrophins and receptors is markedly decreased.
Gianfranco Olivieri+6 more
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Soluble low affinity nerve growth factor receptor (sLNGFR) may regulate pain in knee osteoarthritis.
Clinical and Experimental Rheumatology, 2023OBJECTIVES Nerve growth factor β (β-NGF) is a protein which is important to the development of neurons particularly those involved in the transmission of pain and is central to the experience of pain in osteoarthritis (OA). Direct NGF antagonism has been
A. Altaie+8 more
semanticscholar +1 more source
Endocrine Pathology, 1996
The immunohistochemical localization of nerve growth factor receptor (NGFR)-high-affinity NGFR (trk A) and low-affinity NGFR (LNGFR)-was investigated in 23 neuroblastoma group tumors, 18 pheochromocytomas, 2 mixed neuroendocrine-neural tumors, and 16 retinoblastomas.
Noriko Kimura+3 more
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The immunohistochemical localization of nerve growth factor receptor (NGFR)-high-affinity NGFR (trk A) and low-affinity NGFR (LNGFR)-was investigated in 23 neuroblastoma group tumors, 18 pheochromocytomas, 2 mixed neuroendocrine-neural tumors, and 16 retinoblastomas.
Noriko Kimura+3 more
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Low affinity nerve growth factor receptor, adrenal transplant and Parkinson's disease
Journal of the Neurological Sciences, 1993Immunohistochemistry of low-affinity nerve growth factor receptor (LNGFR) was performed postmortem in the striatum and the adrenal gland of a parkinsonian patient with an adrenal to brain transplantation. Few LNGFR-positive fibers were observed in the necrotic graft.
O, Strada+5 more
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Low-affinity nerve growth factor receptor is associated with motoneuron axonal pathways
Neuroscience Research, 1997The unidentified cell-surface antigen recognized by monoclonal antibody M7412 is distributed along motoneuron axonal outgrowth pathways in chicken embryos. To better characterize its role in motoneuron development, the M7412 antigen was purified from chicken embryos by immunoaffinity chromatography.
Bruno Buisson+6 more
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Low-affinity nerve growth factor receptor immunoreactivity in the human urinary bladder
Neuroscience Letters, 1995The localization of low-affinity nerve growth factor receptor (LNGFR) in the human urinary bladder was examined immunohistochemically using the mouse monoclonal antibody (ME20-4) against human LNGFR. LNGFR immunoreactivity was present in the human urinary bladder.
Ikuo Tooyama+5 more
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Cultured rat Schwann cells express low affinity receptors for nerve growth factor
Brain Research, 1987Schwann cell cultures prepared from postnatal Sprague-Dawley rat sciatic nerves were used to demonstrate the presence of specific receptors for the beta-subunit of nerve growth factor (NGF) on rat Schwann cells. Indirect immunofluorescence microscopy with a monoclonal antineuronal NGF receptor (NGFR) antibody indicated that NGFR antigen was expressed ...
Barbara Kreider+4 more
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