Results 301 to 310 of about 139,660 (338)
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Radiation Oncology Investigations, 1995
AbstractNerve growth factor (NGF) interacts with a low‐affinity NGF receptor (LNGFR) and a high‐affinity Trk receptor in the paracrine regulation of human prostate growth. Both the LNGFR and the Trk receptor localize to the epithelia of the normal prostate. During malignant progression of the prostate, expression of the LNGFR is progressively lost from
Rakhi Dalai +4 more
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AbstractNerve growth factor (NGF) interacts with a low‐affinity NGF receptor (LNGFR) and a high‐affinity Trk receptor in the paracrine regulation of human prostate growth. Both the LNGFR and the Trk receptor localize to the epithelia of the normal prostate. During malignant progression of the prostate, expression of the LNGFR is progressively lost from
Rakhi Dalai +4 more
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Human Pathology, 2001
Low-affinity nerve growth factor receptor (p75) is a member of the tumor necrosis factor receptor family. It may modulate the binding of nerve growth factor (NGF) to the functional high-affinity receptor tyrosine kinase (trk) A.
J. Fanburg-Smith, Markku Miettinen
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Low-affinity nerve growth factor receptor (p75) is a member of the tumor necrosis factor receptor family. It may modulate the binding of nerve growth factor (NGF) to the functional high-affinity receptor tyrosine kinase (trk) A.
J. Fanburg-Smith, Markku Miettinen
semanticscholar +1 more source
Role of low‐affinity p75 receptor in nerve growth factor‐inducible growth arrest of PC12 cells
Journal of Neuroscience Research, 2002AbstractMutant PC12 cell clones (PC84 cells) were obtained by transfection with nerve growth factor (NGF) cDNA. These cells secreted active NGF, extended short processes, and proliferated faster than the parental PC12 cells. These features are of great interest because the parental PC12 cells cease proliferation and extend long processes when ...
Shoei Furukawa +2 more
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Neurochemical Research, 1997
We investigated, by means of in situ hybridization with a digoxigenin-labelled RNA probe, the expression of the low-affinity p75 nerve growth factor receptor (NGFR) in the developing pituitary primordium of the rat. In 13-day pc embryos, intense staining of p75 NGFR mRNA was present in the cytoplasm of all cells of Rathke's pouch.
Marijke Proesmans +2 more
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We investigated, by means of in situ hybridization with a digoxigenin-labelled RNA probe, the expression of the low-affinity p75 nerve growth factor receptor (NGFR) in the developing pituitary primordium of the rat. In 13-day pc embryos, intense staining of p75 NGFR mRNA was present in the cytoplasm of all cells of Rathke's pouch.
Marijke Proesmans +2 more
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Urological Research, 1998
Beta-nerve growth factor (beta-NGF) acts on high- and low-affinity receptors to effect sympathetic innervation. It is produced in the human prostate. This study aimed to demonstrate the presence of beta-NGF receptors and the distribution of p75LNGFR receptor protein in the human prostate.
Alan Paul, Fouad K. Habib
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Beta-nerve growth factor (beta-NGF) acts on high- and low-affinity receptors to effect sympathetic innervation. It is produced in the human prostate. This study aimed to demonstrate the presence of beta-NGF receptors and the distribution of p75LNGFR receptor protein in the human prostate.
Alan Paul, Fouad K. Habib
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Journal of Neuroimmunology, 1993 Cellular and Molecular Neurobiology, 1994
1. Antisense inhibition of gene expression implies that the expression of the target protein is selectively inhibited at either the translational or the transcriptional level by complementary DNA or RNA constructs that are antiparallel to the target sequence. The antisense inhibition strategy provides means to study the roles of individual proteins and
Kirsi Sainio +4 more
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1. Antisense inhibition of gene expression implies that the expression of the target protein is selectively inhibited at either the translational or the transcriptional level by complementary DNA or RNA constructs that are antiparallel to the target sequence. The antisense inhibition strategy provides means to study the roles of individual proteins and
Kirsi Sainio +4 more
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Journal of Cellular Physiology, 1998
In our preceding report, we have shown that nerve growth factor (NGF) and its low-affinity receptor (p75NTR) are expressed in C2C12 myoblasts and downregulated during myogenic differentiation. Furthermore, NGF affects myogenic differentiation and cell growth via p75NTR and downregulation of p75NTR is essential for myogenic differentiation (Seidl et al.,
Erck, Christian +3 more
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In our preceding report, we have shown that nerve growth factor (NGF) and its low-affinity receptor (p75NTR) are expressed in C2C12 myoblasts and downregulated during myogenic differentiation. Furthermore, NGF affects myogenic differentiation and cell growth via p75NTR and downregulation of p75NTR is essential for myogenic differentiation (Seidl et al.,
Erck, Christian +3 more
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Characterization of the Glycosylation on Recombinant Human Low-Affinity Nerve Growth Factor Receptor
1992Publisher Summary To study the structure of the nerve growth factor (NGF) binding region in this glycoprotein, a recombinant form (rhNGF-R) was prepared that contains the N-terminal 222 amino acids ending just before the transmembrane region of the native full length receptor. rhNGF-R is a soluble form of the receptor that retains its ability to bind
Barbara Chapman +6 more
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Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75
Neuroscience Letters, 1998Endogenous nerve growth factor (NGF) has been shown to be an important mediator of inflammatory pain and exogenous application of recombinant human NGF (rhNGF) produces pain and hyperalgesia in animals and humans. Since NGF can act through two receptors types, the high affinity tyrosine kinase A (trkA) receptor and the low affinity p75 receptor, we ...
Ilka Bergmann +3 more
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