Vibrational analysis on the revised potential energy curve of the low-barrier hydrogen bond in photoactive yellow protein [PDF]
Computational and Structural Biotechnology Journal, 2016 Photoactive yellow protein (PYP) has a characteristic hydrogen bond (H bond) between p-coumaric acid chromophore and Glu46, whose OH bond length has been observed to be 1.21 Å by the neutron diffraction technique [Proc. Natl. Acad. Sci.
Yusuke Kanematsu +3 more
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Low-Barrier Hydrogen Bond in Fujikurin A-D: A Computational Study. [PDF]
ACS Omega, 2022 The compounds Fujikurin A, B, and D, recently isolated from Fusarium fujikuroi, possess intramolecular low-barrier hydrogen bonds (LBHBs), which are hydrogen bonds with a very low-energy barrier for proton transfer. The isolated compounds have a hydrogen-bonded proton that appears to rapidly switch between two equilibrium states via a transition state (
Tanaka H +3 more
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Absorption wavelength along chromophore low-barrier hydrogen bonds
iScience, 2022 Summary: In low-barrier hydrogen bonds (H-bonds), the pKa values for the H-bond donor and acceptor moieties are nearly equal, whereas the redox potential values depend on the H+ position. Spectroscopic details of low-barrier H-bonds remain unclear. Here,
Masaki Tsujimura +3 more
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Low-barrier hydrogen bond in photoactive yellow protein [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2009 Low-barrier hydrogen bonds (LBHBs) have been proposed to play roles in protein functions, including enzymatic catalysis and proton transfer. Transient formation of LBHBs is expected to stabilize specific reaction intermediates. However, based on experimental results and theoretical considerations, arguments against the importance of LBHB in proteins ...
Shigeo Yamaguchi +2 more
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Contribution of a low-barrier hydrogen bond to catalysis is not significant in ketosteroid isomerase. [PDF]
Mol Cells, 2015 Low-barrier hydrogen bonds (LBHBs) have been proposed to have important influences on the enormous reaction rate increases achieved by many enzymes. Δ(5)-3-ketosteroid isomerase (KSI) catalyzes the allylic isomerization of Δ(5)-3-ketosteroid to its conjugated Δ(4)-isomers at a rate that approaches the diffusion limit. Tyr14, a catalytic residue of KSI,
Jang DS +7 more
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Direct evidence of a low barrier hydrogen bond in the catalytic triad of a Serine protease. [PDF]
Sci Rep, 2018 AbstractSerine proteases are one of the largest groups of enzymes, found in both eukaryotes and prokaryotes, and are responsible for many different functions. The detailed information about the hydrogen-bonds in the catalytic triad (Asp…His…Ser) of these enzymes is of importance in order to fully understand the mechanism of action. The aspartate of the
Agback P, Agback T.
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A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad. [PDF]
Sci Adv, 2018 Substrate participation in forming a catalytic triad aids in antibiotic resistance by aminoglycoside N3 -acetyltransferases.
Kumar P, Serpersu EH, Cuneo MJ.
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Environmental Contributions to Proton Sharing in Protein Low-Barrier Hydrogen Bonds. [PDF]
BiochemistryHydrogen bonds (H-bonds) are central to biomolecular structure and dynamics. Although H-bonds are typically characterized by well-defined proton positions, proton delocalization has been proposed to play a role in facilitating enzyme catalysis and allostery in some systems.
Lin J +10 more
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The Low Barrier Hydrogen Bond in Enzymatic Catalysis [PDF]
Journal of Biological Chemistry, 1998 W Wallace Cleland +2 more
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Short hydrogen bonds in the catalytic mechanism of serine proteases [PDF]
Journal of the Serbian Chemical Society, 2008 The survey of crystallographic data from the Protein Data Bank for 37 structures of trypsin and other serine proteases at a resolution of 0.78–1.28 Å revealed the presence of hydrogen bonds in the active site of the enzymes, which are formed between the ...
VLADIMIR LESKOVAC +4 more
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