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Cytotoxic Effect of Low-Density Lipoproteins
Bulletin of Experimental Biology and Medicine, 2003The cytopathogenic effect of various modified lipoproteins on cultured peritoneal macrophages was studied in vitro. After minor peroxide modification lipoproteins induced apoptosis of macrophages. Immune complexes containing oxidized lipoproteins caused cell necrosis.
V A, Nagornev +4 more
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Desialylated low density lipoproteins and atherosclerosis
1992Oxidative modification of LDL is accompanied by a number of compositional and structural changes, now well known. In addition, other atherogenic modifications of LDL exist, such as desialylation. The present article summarizes the recent data related to desialylated LDL and to the presence of these LDL in blood plasma of patients with coronary ...
N, Dousset +3 more
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Circulating low density lipoprotein (LDL)
Hormone Molecular Biology and Clinical Investigation, 2018Abstract Low-density lipoprotein (LDL) particles are known as atherogenic agents in coronary artery diseases. They modify to other electronegative forms and may be the subject for improvement of inflammatory events in vessel subendothelial spaces. The circulating LDL value is associated with the plasma PCSK-9 level.
Mohsen, Khosravi +2 more
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Oxidized low-density lipoprotein and atherosclerosis
International Journal of Clinical & Laboratory Research, 1996Atherosclerosis is the leading cause of morbidity and mortality in western society. The most important risk factors for atherosclerosis include smoking, hypertension, dyslipidemia, diabetes and a family history of premature atherosclerosis. Several studies indicate that an increased plasma low density lipoprotein (LDL) cholesterol constitutes a major ...
S, Devaraj, I, Jialal
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Mild autoxidation of low density lipoproteins
Pharmaceutica Acta Helvetiae, 1996The autoxidation of low density lipoproteins was investigated in a closed system, with limited amount of oxygen. The concentrations of several components were monitored: oxygen, aldehydic oxidation products and alpha-tocopherol. The concentration of lipid radicals generated in the processes of lipid peroxidation was monitored by the EPR spin trapping ...
Ukrainczyk, Tatjana +2 more
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The catabolism of very low density lipoproteins
Canadian Journal of Biochemistry and Cell Biology, 1985The lipolysis of very low density lipoproteins (VLDL) in vitro is a useful model for the study of the process of conversion of this triacylglycerol rich lipoprotein into low (LDL) and high (HDL) density lipoproteins. Data is reviewed to show that a portion of surface cholesterol and phospholipid which becomes redundant during lipolysis is lost from ...
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Cyclosporine, Low-Density Lipoprotein, and Cholesterol
Mayo Clinic Proceedings, 1988Lipoproteins are known to be able to transport a variety of drugs. This report suggests that low-density lipoprotein not only functions as an important carrier of cyclosporine in plasma but also facilitates transport of cyclosporine across the cell membrane by means of the low-density lipoprotein receptor. Such a mechanism would explain (1) the similar
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Immunoassay of Plasma Low-Density Lipoproteins
Science, 1970An immunoassay was developed for determining the concentration of the protein moiety of the low-density lipoproteins of human plasma. The concentration of this protein in the plasma was variable; it was higher than normal on the average in patients with familial hyperbetalipoproteinemia (type II) and endogenous hyperlipemia (type IV) and lower than ...
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Lipoprotein Metabolism: Chylomicrons, Very-Low-Density Lipoproteins and Low-Density Lipoproteins
2015Verne Schumaker, Audra Lembertas
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