Results 31 to 40 of about 1,184,339 (384)

Oxidized low‐density lipoprotein in inflammation‐driven thrombosis

Journal of Thrombosis and Haemostasis, 2018
Thrombosis is the defining feature of the most prevalent causes of cardiovascular mortality, such as myocardial infarction, stroke, and pulmonary artery embolism.
G. Obermayer, T. Afonyushkin, T. Afonyushkin, C. Binder, C. Binder   +4 more
semanticscholar   +1 more source

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.

Journal of the American Medical Association (JAMA), 2016
Importance Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering ...
L. Lotta, S. Sharp, S. Burgess, J. Perry, I. Stewart, Sara M. Willems, J. Luan, E. Ardanaz, L. Arrióla, B. Balkau, H. Boeing, P. Deloukas, N. Forouhi, P. Franks, S. Grioni, R. Kaaks, T. Key, C. Navarro, P. Nilsson, K. Overvad, D. Palli, S. Panico, J. Quirós, E. Riboli, O. Rolandsson, C. Sacerdote, Elena C Salamanca, N. Slimani, A. Spijkerman, A. Tjønneland, R. Tumino, D. van der A, Y. T. van der Schouw, M. McCarthy, I. Barroso, S. O’Rahilly, D. Savage, N. Sattar, C. Langenberg, R. Scott, N. Wareham   +40 more
semanticscholar   +1 more source

Causal Models with Constraints [PDF]

arXiv, 2023
Causal models have proven extremely useful in offering formal representations of causal relationships between a set of variables. Yet in many situations, there are non-causal relationships among variables. For example, we may want variables $LDL$, $HDL$, and $TOT$ that represent the level of low-density lipoprotein cholesterol, the level of lipoprotein
arxiv  

Atherogenic Lipoprotein Determinants of Cardiovascular Disease and Residual Risk Among Individuals With Low Low‐Density Lipoprotein Cholesterol

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Levels of LDL (low‐density lipoprotein) cholesterol in the population are declining, and increasing attention is being focused on residual lipid‐related pathways of atherosclerotic cardiovascular disease risk beyond LDL cholesterol.
P. Lawler, A. Akinkuolie, Audrey Y. Chu, Svati H. Shah, W. Kraus, D. Craig, Latha Padmanabhan, R. Glynn, P. Ridker, D. Chasman, S. Mora   +10 more
semanticscholar   +1 more source

A comparative study of the lipid panel levels at different duration time and temperature storage [PDF]

arXiv, 2023
Background: the stability of serum specimen during time storage is importance in clinical and medical science researches in addition of diagnosis. Lipids are organic molecules that classified into 8 classes: fatty acids, phospholipids, glycerolipids, saccharolipids, polyketides, prenol lipids, sterol, and sphingolipids.
arxiv  

Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis

Biomedicines, 2021
Despite advances in pharmacotherapy, intervention devices and techniques, residual cardiovascular risks still cause a large burden on public health. Whilst most guidelines encourage achieving target levels of specific lipids and lipoproteins to reduce ...
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu   +5 more
doaj   +1 more source

High expression of antioxidant proteins in dendritic cells: possible implications in atherosclerosis [PDF]

Mol Cell Proteomics 5 (04/2006) 726-36, 2006
Dendritic cells (DCs) display the unique ability to activate naive T cells and to initiate primary T cell responses revealed in DC-T cell alloreactions. DCs frequently operate under stress conditions. Oxidative stress enhances the production of inflammatory cytokines by DCs.
arxiv   +1 more source

Low Density Lipoprotein Oxidation and Its Pathobiological Significance*

Journal of Biological Chemistry, 1997
Background The fact that low density lipoprotein (LDL) 1 is extremely sus- ceptible to oxidative damage has been known for some time (1, 2), but until quite recently this was primarily a nuisance for the student of lipoprotein metabolism.
D. Steinberg
semanticscholar   +1 more source

Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases ...
Feroz Ahmad, Robert D. Mitchell, Tom Houben, Angela Palo, Tulasi Yadati, Andrew J. Parnell, Ketan Patel, Ronit Shiri‐Sverdlov, David S. Leake   +8 more
doaj   +1 more source

Geometric and Electromagnetic Aspects of Fusion Pore Making [PDF]

Systems Biology 2 (2011), pp. 505-538, 2009
For regulated exocytosis, we model the morphology and dynamics of the making of the fusion pore or porosome as a cup-shaped lipoprotein structure (a dimple or pit) on the cytosol side of the plasma membrane. We describe the forming of the dimple by a free boundary problem.
arxiv   +1 more source