Results 41 to 50 of about 2,386 (174)

Platelet aggregation and lipoprotein levels in a patient with familial hypercholescholesterolemia after selective LDL-apheresis

São Paulo Medical Journal
Platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after aphereis selective for low-density lipoprotein (LDL), a lipid-lowering procedure.This treatment reduced plasmatic levels of total and LDL-cholesterol, apo ...
Madalena Nunes da Silva Pares, Elbio Antonio D'Amico, José Mauro Kutner, Dalton de Alencar Fischer Chamone, Sergio Paulo Bydlowski   +4 more
doaj   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy.

Journal of Lipid Research, 1994
To determine the acute and long-term effects of low density lipoprotein (LDL) reduction on cholesterol biosynthesis, we studied changes in the cholesterol precursors mevalonic acid (MVA) and lathosterol in patients with heterozygous familial ...
M Pfohl, R P Naoumova, C Klass, W Knisel, B Jakober, T Risler, G R Thompson   +6 more
doaj   +1 more source

Plasma Dilution After Myocardial Ischemia–Reperfusion Injury Promotes Cardiac Repair, Heart Performance, and Recovery of Motor Function and Endurance in Old Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Plasma dilution at 24 h after I/R improved cardiac remodeling, function, and the physical performance of old male and female mice, through lowered markers of inflammation, fibrosis, reduction of cardiomyocytes' apoptosis, increase in their cell‐cycle re‐entry, and healthier profile of newly synthesized proteome, including the determinants of Jak/Stat ...
Joana Marie C. Cruz, Rana Alzalzalee, Hayden Yeung, Zainab Mahmood, Qile Yang, Negar Morshedian, Zachery R. Robinson, Karan R. Malhotra, Michael J. Conboy, Ahmad Reza Mazahery, Jose B. Nevado, Irina M. Conboy   +11 more
wiley   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, Volume 30, Issue 2, Page 168-175, April 2026.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body

Scientific Reports, 2017
Only free drugs have been believed to be carried into tissues through active or passive transport. However, considering that lipoproteins function as carriers of serum lipids such as cholesterol and triglycerides, we hypothesized that lipoproteins can ...
Hideaki Yamamoto, Tappei Takada, Yoshihide Yamanashi, Masatsune Ogura, Yusuke Masuo, Mariko Harada-Shiba, Hiroshi Suzuki   +6 more
doaj   +1 more source

Effects of Immunoadsorption on Markers of Iron Metabolism: A Case Series

Journal of Clinical Apheresis, Volume 41, Issue 2, April 2026.
ABSTRACT Immunoadsorption selectively eliminates circulating antibodies in antibody‐mediated diseases. Iron deficiency is the most common cause of anemia; however, the potential role of immunoadsorption in contributing to iron depletion remains insufficiently established.
Noemi E. Ginthör, Tobias Niedrist, Gerold Schwantzer, Alexander H. Kirsch, Werner Ribitsch, Andras Deak, Michael Kolland, Daniel Leitinger, Kathrin Eller, Alexander R. Rosenkranz, Katharina Artinger   +10 more
wiley   +1 more source

Transcatheter Intra‐Arterial Delivery of a Platelet‐Derived Extracellular Vesicle‐Enriched Preparation for Attenuating Skeletal Muscle Ischaemia‐Reperfusion Injury in a Rodent Forelimb Model

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Extracellular vesicles (EVs) are non‐replicating, lipid membrane‐bound nanoparticles released by most eukaryotic cells into the extracellular space. When derived from platelets, a subset of EVs can exhibit remarkable anti‐inflammatory and antioxidant properties, making them attractive candidates to attenuate sterile inflammatory states such as
Omar A. Selim, Aida Sarcon, Atta Behfar, Chunfeng Zhao, Steven L. Moran   +4 more
wiley   +1 more source

[Low density lipoprotein apheresis].

Medicina (Kaunas, Lithuania), 2004
Increased blood cholesterol concentration is one of the main factors in ischemic heart disease, development of which is determined by atherosclerotic changes in coronary vessels. Diet and treatment with 3-hydroxi-3-metilglutaril coenzyme A (HMG-CoA) reductase inhibitors helps to reduce low density lipoprotein cholesterol (LDL-Ch) blood concentration up
Remigijus, Zaliūnas, Rimvydas, Slapikas, Olivija, Gustiene, Jonas, Siurkus, Eduardas, Vaitkus   +4 more
openaire   +1 more source

Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Background Studies comparing treatment strategies based on initiation timing—such as starting PCSK9 inhibitor (PCSK9i) therapy sooner versus later after a myocardial infarction (MI)—are prone to immortal time bias. Clone‐censor‐weight methods can address these issues and allow the researcher to emulate a trial in which patients are assigned to
Thomas Cars, Stefan Gustafsson, Queenie Chan, Nafeesa Dhalwani, Shia T. Kent, Andrew Briggs, Chris P. Gale, Anselm Gitt, J. Wouter Jukema, Philippe Gabriel Steg, Johan Sundström, Stefan James, Emil Hagström, M. Alan Brookhart   +13 more
wiley   +1 more source